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The protein encoded by TOMM34 is involved in the import of precursor proteins into mitochondria. Additionally we are shipping Translocase of Outer Mitochondrial Membrane 34 Antibodies (74) and Translocase of Outer Mitochondrial Membrane 34 Kits (12) and many more products for this protein.
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Data show that Tomm34 extensively interacts with the C-terminal structures of Hsp70 (show HSP70 Proteins) selectively in its ATP-bound state and that this interaction is strongly entropically driven.
These results suggest that Tomm34 represents a novel scaffolding co-chaperone of Hsp70 (show HSP70 Proteins) and Hsp90 (show HSP90 Proteins), which may facilitate Hsp70 (show HSP70 Proteins)/Hsp90 (show HSP90 Proteins) cooperation during protein folding
TOMM34 expression in early invasive breast cancer: a biomarker associated with poor outcome.
Results identify Tom34 as a cochaperone of Hsp70 (show HSP70 Proteins)/Hsp90 (show HSP90 Proteins) in mitochondrial protein (show COX6B2 Proteins) import.
Tom34 unlike Tom20 (show TOMM20 Proteins) does not interact with the leader sequences of mitochondrial precursor proteins
Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol
TOMM34 is involved in the growth of colon cancer cells
Data show that NRF-1 (show NFE2L1 Proteins) is the main transcription factor regulating the expression of TOMM34, and that Sp1 (show PSG1 Proteins) interacts with NRF-1 (show NFE2L1 Proteins) to stimulate the promoter's full activity.
The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats.
, mitochondrial import receptor subunit TOM34
, outer mitochondrial membrane translocase (34kD)
, translocase of outer membrane 34 kDa subunit
, Tom34a, translocase of outer mitochondrial membrane 34a
, Tom34b, translocase of outer mitochondrial membrane 34b
, translocase of outer mitochondrial membrane 34a
, translocase of outer mitochondrial membrane 34b
, translocase of outer mitochondrial membrane 34