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TOMM40 is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for protein import into mitochondria (Humphries et al., 2005 [PubMed 15644312]).[supplied by OMIM, May 2008]..
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This study found in middle-aged and aged cohorts that FH altered TOMM40 '523 poly-T genotype associations on memory, and additionally in aged participants for both global decline and cognitive impairment risk.
Our data provide support for TOMM40 variant repeat length as an important contributor to AD-like Medial Temporal Lobe pathology in the absence of APOE (show APOE ELISA Kits) epsilon4.
Survival analyses suggest that AD patients with TOMM40 allele rs2075650-G have an average age of disease onset of 6 years earlier compared with carriers of the A allele. The age of disease onset is earlier if APOE4/4 is present in the Colombian population studied.
report association of APOE (show APOE ELISA Kits) and TOMM40 with behavioural variant frontotemporal dementia, and ARHGAP35 (show GRLF1 ELISA Kits) and SERPINA1 (show SERPINA1 ELISA Kits) with progressive non-fluent aphasia.
Among white women, three single nucleotide polymorphisms (SNPs) (rs2075650 [TOMM40], rs4420638 [APOC1 (show APOC1 ELISA Kits)], and rs429358 [APOE (show APOE ELISA Kits)]) were significantly associated with survival to 90 years after correction for multiple testing (p < .001); rs4420638 and rs429358 were also significantly associated with healthy aging (p = .02). In African American women, no SNP was associated with longevity. In Hispanic women, 7 SNPs in linkage dise
Each epsilon4 allele doubled the risk for AD dementia and the dose effect was evident. Almost identical effect size and effect pattern were observed for TOMM40 '523-L
meta-analysis to investigate the association between rs2075650 polymorphism and Alzheimer's disease (AD) in Asian, Caucasian, and mixed populations; analysis shows TOMM40 rs2075650 polymorphism is associated with AD susceptibility in Asian, Caucasian, and mixed populations
Results reveal an association of APOE (show APOE ELISA Kits) epsilon3/3-TOMM40'523 haplotypes with cognitive decline in community-based older persons such that the S/S poly-T genotype is related to faster cognitive decline, primarily in the domains of episodic and semantic memory.
These findings indicated that variants in TOMM40/APOE (show APOE ELISA Kits)/APOC1 (show APOC1 ELISA Kits) region might be associated with human longevity. Further studies are needed to identify the causal genetic variants influencing human longevity.
Our results do not support the notion that TOMM40 poly-T repeat variants have independent effects on Parkinson's disease with dementia and Dementia with Lewy bodies pathology
the interaction of alpha-Syn with the mitochondrial protein import machinery, in particular Tom40, might be an upstream event in alpha-Syn-induced neurotoxicity.
Data demonstrate that LktA interacts with the Tom22 (show TOMM22 ELISA Kits) and Tom40 components of the translocase of the outer mitochondrial membrane (TOM), which suggests that import of this toxin into mitochondria involves a classical import pathway for endogenous proteins.
TOMM40 is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for protein import into mitochondria (Humphries et al., 2005
translocase of outer mitochondrial membrane 40
, mitochondrial import receptor subunit TOM40 homolog
, translocase of outer membrane 40 kDa subunit homolog
, translocase of outer mitochondrial membrane 40 homolog a
, mitochondrial outer membrane protein
, protein Haymaker
, haymaker protein
, mitochondrial outer membrane protein 35
, mitochondrial outer membrane protein of 35 kDa
, mitochondrial outer membrane protein of 38 kDa
, outer membrane protein 38 kDa
, translocase of outer mitochondrial membrane 40A