Translocase of Outer Mitochondrial Membrane 40 Homolog (Yeast) Proteins (TOMM40)

TOMM40 is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for protein import into mitochondria (Humphries et al., 2005 [PubMed 15644312]).[supplied by OMIM, May 2008].. Additionally we are shipping TOMM40 Antibodies (43) and TOMM40 Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TOMM40 10452 O96008
TOMM40 53333 Q9QYA2
Rat TOMM40 TOMM40 308416 Q75Q40
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Top TOMM40 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
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Yeast Xenopus tropicalis His tag   1 mg Log in to see 60 to 71 Days
$2,907.67
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Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$2,907.67
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Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,986.50
Details
Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$318.85
Details

TOMM40 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Translocase of Outer Mitochondrial Membrane 40 Homolog (Yeast) (TOMM40) Interaction Partners

Human Translocase of Outer Mitochondrial Membrane 40 Homolog (Yeast) (TOMM40) interaction partners

  1. Results from this exploratory analysis suggest that regulatory element methylation levels within the larger TOMM40-APOE (show APOE Proteins)-APOC2 (show APOC2 Proteins) gene region correlate with AD-related biomarkers and TOMM40 or APOE (show APOE Proteins) gene expression in AD.

  2. This study demonstrated that the association of TOMM40 '523-L with cognitive decline is primarily mediated by common neuropathologies. By contrast, the association of TOMM40 '523-S/S is relatively independent of these pathologies.

  3. This study found in middle-aged and aged cohorts that FH altered TOMM40 '523 poly-T genotype associations on memory, and additionally in aged participants for both global decline and cognitive impairment risk.

  4. Our data provide support for TOMM40 variant repeat length as an important contributor to AD-like Medial Temporal Lobe pathology in the absence of APOE (show APOE Proteins) epsilon4.

  5. Survival analyses suggest that AD patients with TOMM40 allele rs2075650-G have an average age of disease onset of 6 years earlier compared with carriers of the A allele. The age of disease onset is earlier if APOE4/4 is present in the Colombian population studied.

  6. report association of APOE (show APOE Proteins) and TOMM40 with behavioural variant frontotemporal dementia, and ARHGAP35 (show GRLF1 Proteins) and SERPINA1 (show SERPINA1 Proteins) with progressive non-fluent aphasia.

  7. Among white women, three single nucleotide polymorphisms (SNPs) (rs2075650 [TOMM40], rs4420638 [APOC1 (show APOC1 Proteins)], and rs429358 [APOE (show APOE Proteins)]) were significantly associated with survival to 90 years after correction for multiple testing (p < .001); rs4420638 and rs429358 were also significantly associated with healthy aging (p = .02). In African American women, no SNP was associated with longevity. In Hispanic women, 7 SNPs in linkage dise

  8. Each epsilon4 allele doubled the risk for AD dementia and the dose effect was evident. Almost identical effect size and effect pattern were observed for TOMM40 '523-L

  9. meta-analysis to investigate the association between rs2075650 polymorphism and Alzheimer's disease (AD) in Asian, Caucasian, and mixed populations; analysis shows TOMM40 rs2075650 polymorphism is associated with AD susceptibility in Asian, Caucasian, and mixed populations

  10. Results reveal an association of APOE (show APOE Proteins) epsilon3/3-TOMM40'523 haplotypes with cognitive decline in community-based older persons such that the S/S poly-T genotype is related to faster cognitive decline, primarily in the domains of episodic and semantic memory.

Mouse (Murine) Translocase of Outer Mitochondrial Membrane 40 Homolog (Yeast) (TOMM40) interaction partners

  1. the interaction of alpha-Syn with the mitochondrial protein (show COX6B2 Proteins) import machinery, in particular Tom40, might be an upstream event in alpha-Syn-induced neurotoxicity.

Cow (Bovine) Translocase of Outer Mitochondrial Membrane 40 Homolog (Yeast) (TOMM40) interaction partners

  1. Data demonstrate that LktA interacts with the Tom22 (show TOMM22 Proteins) and Tom40 components of the translocase of the outer mitochondrial membrane (TOM), which suggests that import of this toxin into mitochondria involves a classical import pathway for endogenous proteins.

TOMM40 Protein Profile

Protein Summary

TOMM40 is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for protein import into mitochondria (Humphries et al., 2005

Gene names and symbols associated with TOMM40

  • translocase of outer mitochondrial membrane 40 homolog (yeast) (tomm40)
  • translocase of outer mitochondrial membrane 40 homolog L homeolog (tomm40.L)
  • translocase of outer mitochondrial membrane 40 (TOMM40)
  • translocase of outer mitochondrial membrane 40 homolog (yeast) (Tomm40)
  • translocase of outer mitochondrial membrane 40 (Tomm40)
  • AW539759 protein
  • C19orf1 protein
  • D19S1177E protein
  • Mom35 protein
  • OM38 protein
  • PER-EC1 protein
  • PEREC1 protein
  • Tom40 protein
  • Tom40A protein
  • tomm40-a protein
  • wu:fb68h07 protein
  • zgc:64168 protein

Protein level used designations for TOMM40

translocase of outer mitochondrial membrane 40 , mitochondrial import receptor subunit TOM40 homolog , translocase of outer membrane 40 kDa subunit homolog , translocase of outer mitochondrial membrane 40 homolog a , mitochondrial outer membrane protein , p38.5 , protein Haymaker , haymaker protein , mitochondrial outer membrane protein 35 , mitochondrial outer membrane protein of 35 kDa , mitochondrial outer membrane protein of 38 kDa , outer membrane protein 38 kDa , translocase of outer mitochondrial membrane 40A

GENE ID SPECIES
322645 Danio rerio
380301 Xenopus laevis
10452 Homo sapiens
53333 Mus musculus
308416 Rattus norvegicus
611055 Canis lupus familiaris
510219 Bos taurus
100731084 Cavia porcellus
101111570 Ovis aries
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