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TOMM40 is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for protein import into mitochondria (Humphries et al., 2005 [PubMed 15644312]).[supplied by OMIM, May 2008].. Additionally we are shipping TOMM40 Antibodies (37) and TOMM40 Kits (11) and many more products for this protein.
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Survival analyses suggest that AD patients with TOMM40 allele rs2075650-G have an average age of disease onset of 6 years earlier compared with carriers of the A allele. The age of disease onset is earlier if APOE4/4 is present in the Colombian population studied.
report association of APOE (show APOE Proteins) and TOMM40 with behavioural variant frontotemporal dementia, and ARHGAP35 (show GRLF1 Proteins) and SERPINA1 (show SERPINA1 Proteins) with progressive non-fluent aphasia.
Among white women, three single nucleotide polymorphisms (SNPs) (rs2075650 [TOMM40], rs4420638 [APOC1 (show APOC1 Proteins)], and rs429358 [APOE (show APOE Proteins)]) were significantly associated with survival to 90 years after correction for multiple testing (p < .001); rs4420638 and rs429358 were also significantly associated with healthy aging (p = .02). In African American women, no SNP was associated with longevity. In Hispanic women, 7 SNPs in linkage dise
Each epsilon4 allele doubled the risk for AD dementia and the dose effect was evident. Almost identical effect size and effect pattern were observed for TOMM40 '523-L
meta-analysis to investigate the association between rs2075650 polymorphism and Alzheimer's disease (AD) in Asian, Caucasian, and mixed populations; analysis shows TOMM40 rs2075650 polymorphism is associated with AD susceptibility in Asian, Caucasian, and mixed populations
Results reveal an association of APOE (show APOE Proteins) epsilon3/3-TOMM40'523 haplotypes with cognitive decline in community-based older persons such that the S/S poly-T genotype is related to faster cognitive decline, primarily in the domains of episodic and semantic memory.
These findings indicated that variants in TOMM40/APOE (show APOE Proteins)/APOC1 (show APOC1 Proteins) region might be associated with human longevity. Further studies are needed to identify the causal genetic variants influencing human longevity.
Our results do not support the notion that TOMM40 poly-T repeat variants have independent effects on Parkinson's disease with dementia and Dementia with Lewy bodies pathology
rs2075650 polymorphism in TOMM40 gene may increase the risk of Alzheimer disease.
investigate the influence of the TOMM40 intron 6 poly-T variant (rs10524523) on TOMM40 gene expression and cognitive abilities and decline in a cohort of 1613 community-dwelling elderly volunteers
the interaction of alpha-Syn with the mitochondrial protein (show COX6B2 Proteins) import machinery, in particular Tom40, might be an upstream event in alpha-Syn-induced neurotoxicity.
Data demonstrate that LktA interacts with the Tom22 (show TOMM22 Proteins) and Tom40 components of the translocase of the outer mitochondrial membrane (TOM), which suggests that import of this toxin into mitochondria involves a classical import pathway for endogenous proteins.
TOMM40 is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for protein import into mitochondria (Humphries et al., 2005
translocase of outer mitochondrial membrane 40
, mitochondrial import receptor subunit TOM40 homolog
, translocase of outer membrane 40 kDa subunit homolog
, translocase of outer mitochondrial membrane 40 homolog a
, mitochondrial outer membrane protein
, protein Haymaker
, haymaker protein
, mitochondrial outer membrane protein 35
, mitochondrial outer membrane protein of 35 kDa
, mitochondrial outer membrane protein of 38 kDa
, outer membrane protein 38 kDa
, translocase of outer mitochondrial membrane 40A