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TRAM1 encodes a multi-pass membrane protein that is part of the mammalian endoplasmic reticulum. Additionally we are shipping TRAM1 Antibodies (50) and TRAM1 Kits (5) and many more products for this protein.
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The model had 92% sensitivity and 92% specificity. We obtained similar results in the independent validation cohort. AIB1 (show NCOA3 Proteins) and EIF5A2 (show EIF5A2 Proteins) show promise for the noninvasive detection of bladder cancer. The model based on AIB1 (show NCOA3 Proteins), EIF5A2 (show EIF5A2 Proteins), and NMP22 outperformed each of the three individual biomarkers for detecting Bladder cancer.
our study implicates that AIB1 (show NCOA3 Proteins) is a molecular target of sorafenib and downregulation of AIB1 (show NCOA3 Proteins) contributes to the anti-tumor effects of sorafenib
our studies illustrate that SRC-3 (show NCOA3 Proteins) overexpression is clinically and functionally relevant to the progression of human ESCC.
Data indicate that phosphorylated cortactin recruits Vav2 to activate Rac3 and promote invadopodial maturation in invasive breast cancer cells.
Estrogen receptor (show ESR1 Proteins) recruits steroid receptor coactivator (show SRA1 Proteins)-3 primary coactivator and secondary coactivators, p300/CBP (show CREBBP Proteins) and CARM1 (show CARM1 Proteins) to regulate genetic transcription.
we identify a positive feedback regulatory loop consisting of XBP1 (show XBP1 Proteins) and NCOA3 (show NCOA3 Proteins) that maintains high levels of NCOA3 (show NCOA3 Proteins) and XBP1 (show XBP1 Proteins) expression in breast cancer tissues.
loss of miR-17 and miR (show MLXIP Proteins)-20b enhanced breast cancer resistance to taxol by upregulating NCOA3 (show NCOA3 Proteins) levels.
Data (including data from studies of hydrogen-deuterium exchange coupled to mass spectrometry in presence of denaturants) suggest that, for peptide fragments of human ACTR (show NCOA3 Proteins) and mouse Crebbp (show CREBBP Proteins) representing disordered interaction domains, exchange rates are changed dramatically by high concentrations of denaturants guanidinium chloride or urea. (ACTR (show NCOA3 Proteins) = activator of thyroid and retinoid receptor; Crebbp (show CREBBP Proteins) = CREB binding protein (show CREBBP Proteins))
Data suggest that steroid receptor (show ESR2 Proteins) coactivators (NCOA1 (show NCOA1 Proteins), NCOA2 (show NCOA2 Proteins), NCOA3 (show NCOA3 Proteins)) are over-expressed in a number of hormone-dependent cancers where they promote tumor growth, invasion, metastasis, and chemo-resistance; with their multiple roles in cancer, steroid receptor (show ESR2 Proteins) coactivators are promising targets for development of antineoplastic agents that can interfere with their function. [REVIEW]
Here, we reported the novel finding that depletion of SRC-3 (show NCOA3 Proteins) enhanced sensitivity of breast and lung cancer cells to HDAC (show HDAC3 Proteins) inhibitors (SAHA and romidepsin). In contrast, overexpression of SRC-3 (show NCOA3 Proteins) decreased SAHA-induced cancer cell apoptosis. Furthermore, we found that SRC-3 (show NCOA3 Proteins) inhibitor bufalin increased cancer cell apoptosis induced by HDAC (show HDAC3 Proteins) inhibitors. The combination of bufalin and SAHA was particular efficient in attenuating
TRAM1 (show NCOA3 Proteins) plays an essential role in the M1 polarization of microglia. TRAM1 (show NCOA3 Proteins) increases M1-related gene expression.
These data indicate that TRAM is recognized by the signal recognition particle and translocon components, and suggest a membrane topology with eight transmembrane segments, including several poorly hydrophobic segments.
This gene encodes a multi-pass membrane protein that is part of the mammalian endoplasmic reticulum. The encoded protein influences glycosylation and facilitates the translocation of secretory proteins across the endoplasmic reticulum membrane by regulating which domains of the nascent polypeptide chain are visible to the cytosol during a translocational pause.
, amplified in breast cancer 1 protein
, class E basic helix-loop-helix protein 42
, receptor-associated coactivator 3
, steroid receptor coactivator protein 3
, thyroid hormone receptor activator molecule 1
, translocating chain-associated membrane protein 1
, translocating chain-associating membrane protein
, translocation-associating membrane protein 1
, translocating chain-associating membrane protein 1
, translocation associated membrane protein 1
, Translocation-associated membrane protein 1
, translocating chain-associated membrane protein 1-like 1
, translocation associated membrane protein 1-like 1