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The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Additionally we are shipping Translocation Protein 1 Antibodies (34) and Translocation Protein 1 Proteins (7) and many more products for this protein.
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Results show higher SEC62 in the lymph node metastases from head and neck squamous cell carcinomas and cervical cancer of unknown primary patients compared with the primary tumor. Tumors from N1 to N3 stage exhibit increasing SEC62 expression in the lymphatic metastases. Its knockdown resulted in tumor cell line migration inhibition while, its overexpression stimulated cell migration.
High Sec62 expression is associated with dysplastic cervical lesions.
identify Sec62 as a critical molecular component in maintenance and recovery of endoplasmic reticulum homeostasis
these studies identify TLOC1 and SKIL as driver genes at 3q26 and more broadly suggest that cooperating genes may be coamplified in other regions with somatic copy number gain.
Sec62 overproduction significantly correlates with reduced non-small lung cancer patient survival.
Phosphorylation of Sec63 by CK2 enhanced its binding to Sec62
Silencing the SEC62 gene inhibits post-translational transport of small presecretory proteins into endoplasmic reticulum.
the Sec62-dependent translocation pathway serves as a fail-safe mechanism to ensure efficient secretion of small proteins and provides cells with an opportunity to regulate secretion of small proteins independent of the signal recognition particle pathway
These results revealed that cyclin B1 and Sec62 may be candidate biomarkers and potential therapeutic targets for HBV-related HCC recurrence after surgery.
The results indicate that SEC62 represents a potential candidate oncogene in the amplified 3q region in cases of non-small cell lung cancer.
Our data indicate a crucial function of Sec62 in the response to thapsigargin-induced endoplasmic reticulum stress.
after silencing of SEC62 the cell migration and the invasive potential of the cells was blocked or at least dramatically reduced while cell viability was hardly affected. SEC62 gene may indeed be considered a target gene in the therapy of various tumors
The gene TLOC1/SEC62 revealed the highest frequency (50%) of copy number gains in the prostate cancer and was found to be up-regulated at the mRNA level.
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.
translocation protein 1
, translocation protein SEC62
, uncharacterized protein LOC696989
, hypothetical protein
, membrane protein SEC62, S.cerevisiae, homolog of