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The protein encoded by TM4SF5 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family.
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The review discusses the antifibrotic strategies that target TM4SF5 and its associated protein networks that regulate the intracellular signaling necessary for fibrotic functions of hepatocytes.
Replacement of the transmembrane 4 L six family protein TM4SF1 or TM4SF4 C-terminus with that of TM4SF5 increased spheroids growth, transwell migration, and invasive dissemination from spheroids in 3D collagen gels.
TM4SF5-miR-4697-3P- CTD-2354A18.1 may play a key role in the pathogenesis of gastric cancer
TM4SF5-positive tumors exhibited locally-increased CD44 (show CD44 ELISA Kits) expression, suggesting tumor cell differentiation
TM4SF5 interacted with CD151 (show CD151 ELISA Kits), and caused the internalization of CD63 (show CD63 ELISA Kits) from the cell surface.
TM4SF5-specific monoclonal antibody has a therapeutic effect against colon cancer.
TM4SF5 expression in SNU761 cells caused invasive extracellular matrix degradation negatively depending on IL-6/IL-6 (show IL6 ELISA Kits) receptor signaling.
Findings demonstrate that TM4SF5 directly binds to and activates FAK (show PTK2 ELISA Kits) in an adhesion-dependent manner, to regulate cell migration and invasion in hepatocellular carcinoma.
TM4SF5 is positively associated with esophageal cancer invasiveness
results indicate that TGFbeta1 (show TGFB1 ELISA Kits)- and growth factor-mediated signalling activities mediate TM4SF5 expression leading to acquisition of mesenchymal cell features, suggesting that TM4SF5 induction may be involved in the development of liver pathologies
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells.
tetraspan transmembrane protein L6H
, transmembrane 4 L6 family member 5
, transmembrane 4 superfamily member 5