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Involved in the conversion of lanosterol to cholesterol.. Additionally we are shipping Transmembrane 7 Superfamily Member 2 Antibodies (35) and Transmembrane 7 Superfamily Member 2 Kits (5) and many more products for this protein.
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Data suggest that, besides the SRE motif, both the inverted CCAAT-box and GC-box2 are essential for full TM7SF2 promoter activation by SREBP-2 (show SREBF2 Proteins).
LBR (show LBR Proteins) mutant variants and sterol reductases can severely interfere with the regular organization of the nuclear envelope and the endoplasmic reticulum.
Results show that the TM7SF2 gene product SR-1 and six chimeras containing SR-1 and Neurospora erg-3 (show SC5DL Proteins) sequences fail to complement sterol c-14 reductase mutants in Neurospora and yeast.
Tm7sf2 deficiency during liver regeneration alters lipid metabolism and generates a stress condition, which, in turn, transiently unbalances hepatocytes cell cycle progression.
The Tm7sf2 insufficiency is responsible for the inhibition of the NF-kappaB (show NFKB1 Proteins) signaling.
the loss of Tm7sf2 alters the expression of proteins involved in epidermal differentiation by reducing the levels of cholesterol sulfate
These results show a significant increase in renal TNFalpha (show TNF Proteins) expression after tunicamycin exposure and in the oedematogenic response in Tm7sf2(-/-) mice.
several genes involved in cell-cycle progression are downregulated in the liver of Tm7sf2((-/-)) mice, whereas genes involved in xenobiotic metabolism are upregulated.
Involved in the conversion of lanosterol to cholesterol.
transmembrane 7 superfamily member 2
, angiogenin ribonuclease 1
, C-14 sterol reductase
, another new gene 1 protein
, delta(14)-sterol reductase
, putative sterol reductase SR-1
, sterol C14-reductase