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Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Additionally we are shipping Transmembrane Emp24 Protein Transport Domain Containing 3 Proteins (6) and and many more products for this protein.
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Human Polyclonal TMED3 Primary Antibody for IHC, IHC (p) - ABIN4360521
Duquet, Melotti, Mishra, Malerba, Seth, Conod, Ruiz i Altaba: A novel genome-wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT-TCF pathway modulators TMED3 and SOX12. in EMBO molecular medicine 2014
Study demonstrates that transmembrane p24 trafficking protein 3 (TMED3) promotes hepatocellular carcinoma (HCC) metastasis and is a potential prognostic biomarker in hepatocellular carcinoma. Study propose that TMED3 promotes HCC metastasis through IL-11/STAT3 signaling.
This genome-wide screen has identified two novel metastatic suppressors: TMED3 and SOX12, the knockdown of which increases metastatic growth after direct seeding.
AIM1, ERGIC1, and TPX2 were shown to be highly expressed especially in prostate cancer tissues, and high mRNA expression of ERGIC1 and TMED3 associated with AR and ERG oncogene expression
Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network (By similarity).
transmembrane emp24 domain-containing protein 3
, p24 gamma 4
, transmembrane emp24 protein transport domain containing 3
, integral type I protein
, p24 family protein gamma-4
, transmembrane emp24 domain containing 3
, membrane protein p24B