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Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Additionally we are shipping Transmembrane Emp24 Protein Transport Domain Containing 3 Proteins (6) and and many more products for this protein.
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Human Polyclonal TMED3 Primary Antibody for IHC, IHC (p) - ABIN4360521
Duquet, Melotti, Mishra, Malerba, Seth, Conod, Ruiz i Altaba: A novel genome-wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT-TCF pathway modulators TMED3 and SOX12. in EMBO molecular medicine 2014
Study demonstrates that transmembrane p24 (show TMED2 Antibodies) trafficking protein 3 (show HSPB3 Antibodies) (TMED3) promotes hepatocellular carcinoma (HCC (show FAM126A Antibodies)) metastasis and is a potential prognostic biomarker in hepatocellular carcinoma. Study propose that TMED3 promotes HCC (show FAM126A Antibodies) metastasis through IL-11 (show IL11 Antibodies)/STAT3 (show STAT3 Antibodies) signaling.
This genome-wide screen has identified two novel metastatic suppressors: TMED3 and SOX12 (show SOX12 Antibodies), the knockdown of which increases metastatic growth after direct seeding.
AIM1 (show AIM1 Antibodies), ERGIC1 (show ERGIC1 Antibodies), and TPX2 (show TPX2 Antibodies) were shown to be highly expressed especially in prostate cancer tissues, and high mRNA expression of ERGIC1 (show ERGIC1 Antibodies) and TMED3 associated with AR and ERG (show ERG Antibodies) oncogene (show RAB1A Antibodies) expression
Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network (By similarity).
transmembrane emp24 domain-containing protein 3
, p24 gamma 4
, transmembrane emp24 protein transport domain containing 3
, integral type I protein
, p24 family protein gamma-4
, transmembrane emp24 domain containing 3
, membrane protein p24B