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Probable serine protease which may play a role in cellular senescence.
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ECRG1 Arg290Gln polymorphism significantly affects the susceptibility but not the prognosis of esophageal squamous cell carcinoma patients in low-risk north Indian population.
This suggests that substitution of the arginine in the conserved catalytic domain of the ECRG1 protein might reduce its catalytic capacity by impacting its 3-dimensional conformation, thereby causing the genetic susceptibility to ESCC. [review]
Data show that the allele types of ECRG1 were Arg/Arg (54.2%), Arg/Gln (45.8%) and Gln/Gln (0.00%), and the allele types of FGFR4 amino acid 388 were Arg/Arg (8.3%), Arg/Gly (54.2%) and Gly/Gly (37.5%).
A statistically significantly increased risk of ESCC was found to be associated with the ECRG1 Arg/Gln and Gln/Gln genotype.
Data show that ECRG4 (show C2orf40 Proteins) interacts directly with ECRG1 to upregulate p21 protein (show NRAS Proteins) expression, induce cell cycle G1 phase block and inhibit cancer cells proliferation in ESCC.
findings indicate that ECRG1 may be a candidate tumor suppressor gene for esophageal cancer involved in cell-cycle control
DNA polymorphisms in the coding region of ECRG1 are associated with poor outcome after surgical resection in esophageal carcinoma.
no significant association between single nucleotide polymorphisms Arg/Arg, Arg/Gln and Gln/Gln and survival in oral squamous cell carcinoma
A comprehensive phenotypic analysis of mice deficient in two of the most widely expressed HAT/DESC proteases, TMPRSS11A and HAT, was performed.
Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.
transmembrane protease, serine 11A
, airway trypsin-like protease 1
, epidermal type II transmembrane serine protease
, epidermal type-II transmembrane serine protease
, esophageal cancer-susceptibility gene 1 protein
, transmembrane protease serine 11A
, serine protease DESC3