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Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway (By similarity). Additionally we are shipping Transmembrane Protein 102 Antibodies (25) and and many more products for this protein.
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our findings reveal a novel oncogenic contribution of CBAP in T-ALL leukemic cells, in addition to its original pro-apoptotic function in cytokine-dependent cell lines and primary hematopoietic cells, by demonstrating its functional role in the regulation of Akt-TSC2-mTORC1 signaling for leukemia cell proliferation. Thus, CBAP represents a novel therapeutic target for many types of cancers and metabolic diseases
CBAP indeed can function as a novel signaling component within the ZAP70/Vav1/talin complex and plays an important role in regulating chemokine-promoted T-cell trafficking.
CBAP (Common receptor Beta chain Associating Protein) is a putative transmembrane protein which associates preferentially with unliganded GM-CSFR beta chain. It functions as a pro-apoptotic protein and is widely expressed in various cell types.
CBAP is a novel component in the TCR signaling pathway, and it modulates thymocyte apoptosis during negative selection.
Shows functional evidence for the homologous human protein.
Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway (By similarity).
common beta-chain associated protein
, transmembrane protein 102, pseudogene