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Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Additionally we are shipping TMEM158 Antibodies (40) and and many more products for this protein.
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Ris1-deficient embryonic fibroblasts were indistinguishable from wild-type cells regarding their proliferation properties, immortalization, senescence and oncogenic transformation
Suggested role of Ris-1 as tumor suppressor gene is not evident, at least in breast cancer.
RIS1 exhibits frameshift mutations in high-frequency microsatellite instability tumors, and its alteration is correlated with mutations in two target genes BAX and TGFBR2, linking it to the mutator pathway in colorectal carcinogenesis.
Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under other conditions that induce senescence. The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway.
40 kDa BINP-binding protein
, BINP binding protein p40BBP
, Ras-induced senescence 1
, brain injury-derived neurotrophic peptide (BINP) binding protein
, ras-induced senescence protein 1
, BINP receptor
, brain specific binding protein
, brain-specific binding protein
, Ras induced senescence 1
, transmembrane protein 158