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Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Additionally we are shipping TMEM59 Antibodies (34) and and many more products for this protein.
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identify the single-span membrane protein TMEM59 as an interactor of FZD and LRP6 (show LRP6 Proteins) and a positive regulator of Wnt (show WNT2 Proteins) signaling. Mechanistically, TMEM59 promotes the formation of multimeric Wnt (show WNT2 Proteins)-FZD assemblies via intramembrane interactions.
The TMEM59 gene identified from our discovery approach was recently implicated in amyloid-beta protein precursor post-translational processing, supporting a role for epigenetic change in LOAD pathology.
TMEM59 affects amyloid precursor protein (show APP Proteins) shedding by reducing its acccess to cellular components.
The results of this study revealed that DCF1-KO mice presented a visual behavioral deficit, higher GAD67 (show GAD1 Proteins) levels, and lower electrophysiological activity in V1 via the GABA system.
Notably, we observed a significant increase in the ATP concentration in Dcf1(-/-) mice, suggesting a greater demand for energy in the absence of Dcf1. We studied the relationship between Dcf1 and NPY (show NPY Proteins) and revealed that Dcf1 plays a critical role in energy balance.
MicroRNA-351 regulates TMEM 59 (DCF1) expression and mediates neural stem cell morphogenesis.
The expression of tmem59 is an important factor contributing to Alzheimer's disease.
Chromosome mapping of 3 proteins (CRSP9 (show MED7 Proteins), ETF1 (show ETF1 Proteins) and TMEM59) in swine
Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding (By similarity).
transmembrane protein 59
, liver membrane-bound protein
, thymic dendritic cell-derived factor 1