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Probably functions in nuclear protein import as nuclear transport receptor. Additionally we are shipping Transportin 2 Antibodies (20) and Transportin 2 Proteins (4) and many more products for this protein.
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IPO3 binds NEMO, promotes its nuclear import, and is critical for DNA damage-dependent NF-kappaB activation.
Studies indicate potential roles of Tranportin-1 and Transportin-2 beyond protein nuclear import.
a role for the nuclear trafficking factor TRN2 (transportin 2) through HuR in cell death
Nuclear import of fused in sarcoma (FUS) is dependent on Transportin, and interference with this transport pathway leads to cytoplasmic redistribution and recruitment of fused in sarcoma (FUS) into stress granules.
Karyopherin beta 2B participates in mRNA export from the nucleus
Transportin-2 mediates nuclear import of HuR protein in vitro
The structure of Kap beta 2 (also known as Transportin) bound to one of its substrates, the NLS of hnRNP A1, that we report here explains the mechanism of substrate displacement by Ran GTPase.
required for Hedgehog signaling in embryos
essential for Hedgehog pathway activation; mediates ciliary translocation of Gli proteins
Early in muscle differentiation, HuR is localized to the nucleus of myoblasts by active Transportin 2 (TRN2)-mediated import.
Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).
, transportin 2 (importin 3, karyopherin beta 2b)
, importin 3
, karyopherin beta 2b, transportin
, karyopherin beta-2b
, karyopherin (importin) beta 2b