anti-Trefoil Factor 2 (TFF2) Antibodies

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. Additionally we are shipping Trefoil Factor 2 Proteins (36) and Trefoil Factor 2 Kits (30) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TFF2 7032 Q03403
TFF2 116592 Q09030
TFF2 21785  
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Top anti-Trefoil Factor 2 Antibodies at

Showing 10 out of 121 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of Spasmolysin expression in HEK293T (A), Raw264.7 (B), rat liver (C) whole cell lysates. 200 μL 13 to 14 Days
Mouse Rabbit Un-conjugated ELISA, IHC (p), WB Western blot analysis of TFF2 using anti-TFF2 antibody . Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.  Lane 1: mouse testis tissue lysates. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-TFF2 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 ug/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for TFF2 at approximately 14KD. The expected band size for TFF2 is at 14KD. IHC analysis of TFF2 using anti-TFF2 antibody .TFF2 was detected in paraffin-embedded section of mouse gaster tissue . Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1ug/ml rabbit anti-TFF2 Antibody  overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen. 100 μg 4 to 6 Days
Rat Mouse Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB Figure.Western Blot Lane1: Rat Stomach Tissue Lane2: Rat Pancreas Tissue Primary Ab: 3µg/mL Rabbit Anti-Rat TFF2 Ab Second Ab: 1:5000 Dilution of HRP-Linked Rabbit Anti-Mouse IgG Ab (Catalog: SAA544Mu09) 100 μg 13 to 16 Days
Human Rabbit Un-conjugated IHC, IHC (p) Anti-TFF2 antibody  ABIN1049400 IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-TFF2 antibody  ABIN1049400 IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg 11 to 14 Days
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of Trefoil factor 2(TFF2) expression in HeLa cells,The lane on the left is treated with the antigen-specific peptide. 100 μL 11 to 12 Days
Human Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded mouse stomach labeled with Anti-TFF2 Polyclonal Antibody, Unconjugated (ABIN736403) followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded human gastric cancer labeled with Anti-TFF2 Polyclonal Antibody, Unconjugated (ABIN736403) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL 3 to 7 Days
Human Rabbit Un-conjugated WB Western blot analysis with recombinant human TFF-2. Lane 1: 50 ng Lane 2: 250 ng 100 μg 2 to 3 Days
Human Rabbit Un-conjugated ICC, IHC, WB 100 μg 15 to 18 Days
Mouse Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Mouse Stomach Tissue; Lane2: Mouse Pancreas Tissue. 100 μg 15 to 18 Days
Rat Rabbit Un-conjugated ICC, IHC, WB Western Blot; Sample: Rat Stomach lysate; Primary Ab: 1µg/ml Rabbit Anti-Rat TFF2 Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) 100 μg 15 to 18 Days

Top referenced anti-Trefoil Factor 2 Antibodies

  1. Human Monoclonal Trefoil Factor 2 Primary Antibody for ICC, IF - ABIN4247273 : Asaka, Nakajima, Momose, Miyamoto, Uehara, Ota: Trefoil factor family 2 protein: a potential immunohistochemical marker for aiding diagnosis of lobular endocervical glandular hyperplasia and gastric-type adenocarcinoma of the uterine cervix. in Virchows Archiv : an international journal of pathology 2019 (PubMed)

More Antibodies against Trefoil Factor 2 Interaction Partners

Human Trefoil Factor 2 (TFF2) interaction partners

  1. Serum concentrations of TFF1 and TFF3 but not TFF2 are higher in women with breast cancer than in women without breast cancer.

  2. results suggest that TFF1 and TFF3, but not TFF2, may have a role in breast tumor pathogenesis

  3. TFF2 is a promising immunohistochemical marker and its identification in uterine cervical secretion is a potentially useful diagnostic test for endocervical glandular lesions with gastric differentiation.

  4. The urine TFF1 and TFF3 levels significantly increased with the progression of chronic kidney disease stages, but not the urine TFF2 levels.

  5. Data show that trefoil factor 2 (TFF2( urine levels continuously decreased with disease progression, TFF2 serum concentrations progressively increased from the early to later chronic kidney disease (CKD) stages, indicating changes in renal function and offering the potential to examine the course of CKD.

  6. this work reveals that TFF2 has tumor-suppressor activity, which may, in part, be regulated by SMAD4.

  7. Data indicate that the antitumor activity of trefoil factor 2 (TFF2) is mediated by an interaction with the transcription factor Sp3 (Sp3) in gastric cancer cells.

  8. Data show the important functions of TFF2 in the gastric mucus barrier, mucus epithelia, immune system, central nervous system, and during fertilization. It has been shown to interact with the gastric mucin MUC6. [Review]

  9. These findings suggest that the rs184432 and rs225359 polymorphisms in TFF1 have protective effects for GC and contribute to the development of GC in Korean individuals.

  10. We reproducibly associate higher expression of the ligand-receptor axis of TFF2 and CXCR4 with BRAF V600E-mutant colon cancer

  11. protease-activated receptor 4 and Trefoil factor 2 are expressed in human colorectal cancer

  12. The structural features of the N-linked N,N'-di-N-acetyllactosediamine-inducing determinant on human TFF2 are discussed.

  13. Human TTF2 is a lectin that binds alpha-GlcNAc-capped mucin 6 g with antibiotic activity against Helicobacter pylori.

  14. Significantly higher levels of TFF2 were in patients with Multiple Organ Dysfunction Syndrome.

  15. There is an association between TFF2 and TFF3 polymorphisms and risk of atrophic gastritis and gastric cancer in Chinese people.

  16. Human gastric TFF2 peptide contains an N-linked fucosylated N,N'-diacetyllactosediamine (LacdiNAc) oligosaccharide

  17. this study indicated that Sp3 was a major regulator of TFF2 expression.

  18. Report TFF2 expression in normal/diseased pancreas and suggest role in tumor cell migration.

  19. Report a novel TFF2 splice variant (EX2TFF2) which correlates with longer overall survival time in cholangiocarcinoma.

  20. TFF2 messenger RNA expression is significantly increased in nasal mucosal brushings during asthma exacerbations in children.

Pig (Porcine) Trefoil Factor 2 (TFF2) interaction partners

  1. Low intestinal TFF2 expression was measured at early maturation stages. Weaning, however, was associated with a distinct response of increased TFF2 expression, indicating an important role in enhancing mucosal integrity.

Mouse (Murine) Trefoil Factor 2 (TFF2) interaction partners

  1. this work demonstrates that lung macrophages rely upon Trefoil factor 2 to promote epithelial proliferation following damage caused by sterile wounding, Nippostrongylus brasiliensis or Bleomycin sulfate

  2. we show a previously unappreciated role for TFF2, produced by either hematopoietic or nonhematopoietic sources, as a pro-proliferative factor for lung epithelial cells under steady-state and infectious injury conditions.

  3. the Tg(Tff1-CreERT2;Tff2-rtTA;Tff3-Luc) strain can confer intermittent transgene expression to gastric epithelial cells that have undergone previous gene modification, and may be suitable to genetically model therapeutic intervention during development, tumorigenesis, and other genetically tractable diseases

  4. Splenic TFF2 is released by vagally modulated memory T cells to suppress expansion of myeloid-derived suppressor cells (MDSC) through CXCR4. TFF2 is important to the anti-inflammatory reflex arc and has an essential role in arresting MDSC proliferation.

  5. hnRNP A1 improves intestinal injury in anti-CD3 antibody-induced enteritis mice through the upregulation of TFF2, which regulates apoptosis and enhances epithelial restoration

  6. Overexpressing Tff2 in cultured cells reduced doubling time in vitro and rapidly increased xenograft tumor size in vivo

  7. Epithelial TFF2 is an important endogenous regulator of gut mucosal homeostasis that can modulate immune and epithelial compartments.

  8. The Tff2 gene is expressed in the hypothalamus and is regulated by food intake. Knockout mice are leaner and have reduced fat mass compared to wild-type.

  9. The increased expression of endogenous TFF2 in response to chronic allergic inflammation is insufficient to prevent the progression of airway inflammation and remodeling in a model of chronic allergic airways disease.

  10. TFF2 functions as a regulator of intestinal homeostasis that suppresses Toxoplasma gondii-driven type 1 inflammation.

  11. TFF2 (trefoil factor 2), an epithelial cell-derived repair molecule, is needed for the control of lung injury caused by the hookworm parasite Nippostrongylus brasiliensis and for type 2 immunity after infection.

  12. results suggest that during retinal cell death periods, requiring a tightly regulated balance between cell survival and cell death, TFF2 acts pro-proliferative and pro-apoptotic at least in developing mouse retinae cultured in vivo

  13. functional NHE2, but not NHE1, is essential for mouse gastric epithelial restitution and TFFs activate epithelial repair via NHE2

  14. Trefoil factor 2 plays a role in the pathogeneasis of airway remodeling in airway disease in the mouse model.

  15. TFF2 transcript-expressing cells are progenitors for mucus neck, parietal and zymogenic, but not for pit or enterochromaffin-like cell lineages in the oxyntic gastric mucosa

  16. TFF2 negatively regulates preneoplastic progression and subsequent tumor development in the stomach, a role that is subverted by promoter methylation during H pylori infection

  17. TFF2 plays a role in restitution after acute gastric epithelial injury, and the effect of exogenous trefoil peptides promote acute wound repair which does not require cyclooxygenase activity.

  18. TFF2 is an allergen-induced lung gene product differentially regulated by Th2 cytokines and STAT6

  19. Intestinal trefoil factor is involved in protection against and recovery from intestinal mucositis induced by radiation and chemotherapy.

  20. spasmolytic peptide expressing metaplasia represents a precursor lineage for the development of dysplasia in this animal model of gastric carcinogenesis.

Trefoil Factor 2 (TFF2) Antigen Profile

Protein Summary

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.

Gene names and symbols associated with anti-Trefoil Factor 2 (TFF2) Antibodies

  • trefoil factor 2 (TFF2) antibody
  • trefoil factor 2 (Tff2) antibody
  • trefoil factor 2 S homeolog (tff2.S) antibody
  • trefoil factor 2 (spasmolytic protein 1) (Tff2) antibody
  • mSP antibody
  • p4 antibody
  • p4-a antibody
  • PSP antibody
  • sml1 antibody
  • SP antibody
  • TFF2 antibody
  • xP4 antibody
  • xp4.1 antibody

Protein level used designations for anti-Trefoil Factor 2 (TFF2) Antibodies

trefoil factor 2 , trefoil factor 2 (spasmolytic protein 1) , trefoil factor family peptide 2 , spasmolysin , spasmolytic polypeptide , spasmolytic protein 1 , pancreatic spasmolytic polypeptide , SP , spasmolytic peptide , spasmolytic peptide 1 , spasmolytic polypeptide 1 , P-domain peptide , TFF p4.1 , putative gastrointestinal growth factor xP4

418534 Gallus gallus
470096 Pan troglodytes
100170653 Felis catus
7032 Homo sapiens
397420 Sus scrofa
116592 Rattus norvegicus
403489 Canis lupus familiaris
616105 Bos taurus
101787738 Cavia porcellus
378510 Xenopus laevis
21785 Mus musculus
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