Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) ELISA Kits

TREM2 encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. Additionally we are shipping TREM2 Antibodies (147) and TREM2 Proteins (19) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
TREM2 54209 Q9NZC2
TREM2 83433 Q99NH8
TREM2 301227  
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Top TREM2 ELISA Kits at

Showing 4 out of 12 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 25.5 pg/mL 62.5 pg/mL - 4000 pg/mL 96 Tests 13 to 16 Days
Mouse 6.5 pg/mL 15.6 pg/mL - 1000 pg/mL 96 Tests 13 to 16 Days
Rat 3.9 pg/mL 15.6-1000 pg/mL Typical standard curve 96 Tests 13 to 16 Days
Human 2.8 pg/mL n/a   96 Tests 11 to 16 Days

More ELISA Kits for TREM2 Interaction Partners

Human Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) interaction partners

  1. This study demonstrated that the first comprehensive analysis of TREM2 exon 2 variants in a group of Polish patients with AD, FTD, and ALS.

  2. In this study, we investigated polymorphisms located in the TREM2 gene region and association with TNF-alpha levels and the intima media thickness of the femoral artery.

  3. These findings suggest a role for TREM2 in the brain of HIV+ individuals may deserve more investigation as a biomarker for HIV-associated neurocognitive disorders and as a possible therapeutic target

  4. The minor allele frequency of rs75932628-T was 0.009 in cases and was not found in any healthy controls which suggests a significant association between rs75932628-T and Late Onset AD risk in our sample (P=0.010).

  5. Downregulating the expression of TREM2 can inhibit the release of inflammatory factors from lipopolysaccharide-stimulated microglia.

  6. TREM2 promotes host resistance against P. aeruginosa keratitis by inhibiting caspase-1-dependent pyroptosis, which provides new insights of TREM2-mediated anti-bacterial immunity.

  7. In conclusion, the authors demonstrate that, although cerebrospinal fluid progranulin is not a diagnostic biomarker for Alzheimer's disease, it may together with sTREM2 reflect microglial activation during the disease.

  8. rs75932628 and rs2234253 polymorphisms of the TREM2 gene are risk factors for frontotemporal lobar degenerationin Caucasian populations [meta-analysis]

  9. Amyloid-beta pathology (A) and tau pathology/neurodegeneration have differing associations with cerebrospinal sTREM2 in patients with Alzheimer's Disease

  10. our present findings suggest the usefulness of serum sTREM2 as a marker for the prevention and early management of hyperglycaemia and exacerbation of inflammation to reduce the risk of cognitive dysfunction in non-obese diabetes patients.

  11. Alzheimer's disease-associated TREM2 variants bind Abeta with equivalent affinity but show loss of function in terms of signaling and Abeta internalization.

  12. Study shows that rare coding variants in TREM2, PLCG2, and ABI3 modulate susceptibility to Alzheimer disease in populations from Argentina, and they may have a European heritage.

  13. dementia-associated TREM2 mutations have subtle effects on microglia biology, consistent with the adult onset of disease in individuals with these mutations.

  14. This review that the TREM2 regulates innate immunity in Alzheimer's disease.

  15. This study reported genetic associations between TREM2 and neurodegenerative diseases, and the effects of these variants on pathology, clinical presentation, and underlying biology.

  16. This review summarizes studies of association between TREM-1, TREM-2, and malignant tumors in the medical field to provide new ideas for study on the correlation between periodontitis and oral cavity cancer [review]

  17. These results demonstrate that TREM2 interacts with neurons and plaques duing amyloid-beta accumulation and R47H impairs this interaction.

  18. In lung cancer cells, TREM2 gene is regulated by p53 tumor suppressor protein.

  19. Study immunostained the cerebral cortex of 299 participants for TREM2 using the Sigma antibody HPA010917 and compared with the macrophage/microglial markers Iba1 and CD68. As expected, Iba1 and CD68 labeled microglia and perivascular macrophages. However, in most cases (284/299), the TREM2 antibody labelled monocytes within vascular lumens, but not microglia or perivascular macrophages.

  20. These data seem to confirm the protective role of TREM2 in the pre-clinical stage of AD. Upregulation of TREM2 in MCI-AD could be a mechanism to counteract the activation of neuroinflammatory processes.

Mouse (Murine) Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) interaction partners

  1. germline knockout of Trem2 or the TREM2(R47H) variant reduces microgliosis around amyloid-beta plaques and facilitates the seeding and spreading of neuritic plaque tau aggregates

  2. Downregulating the expression of TREM2 can inhibit the release of inflammatory factors from lipopolysaccharide-stimulated microglia.

  3. TREM2 is a microglial Amyloid Beta receptor, transducing physiological and Alzheimer's disease pathological effects associated with Amyloid Beta.

  4. Elevated TREM2 gene dosage led to improved memory performance in Alzheimer's disease models.

  5. Authors concluded that TREM2 inhibited neuroinflammation by down-regulating PI3 K/AKT and NF-kB signaling in BV2 microglia.

  6. Study shows that up-regulation of trem2 inhibits hippocampal neuronal apoptosis and alleviates oxidative stress in epilepsy via the PI3K/Akt pathway in Mice.

  7. analyses showed that these TREM-2(+) cells expressed high levels of CCR-7 and CD86 suggesting a potential role of TREM-2 in mediating maturation and migration of DC subsets in allergic airway inflammation.

  8. The present study provides evidence that TREM2 is required for preventing loss of memory and learning in Alzheimer's disease by regulating C/EBPalpha-dependent CD36 expression and the consequent Abeta phagocytosis.

  9. an imbalance of TLR4/TREM2 may be a potential link between AD and systemic inflammation

  10. microglial TREM2 contributes to age-related microglial changes, phagocytic oxidative burst, and loss of neurons with possible detrimental effects during physiological aging.

  11. We demonstrate that amyloid plaque seeding is increased in the absence of functional Trem2. Increased seeding is accompanied by decreased microglial clustering around newly seeded plaques and reduced plaque-associated apolipoprotein E (ApoE).

  12. Study shows that loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain.

  13. Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model.

  14. TREM2 mutation is associated with Alzheimer's disease.

  15. Trem2 R47H variant activates a cryptic splice site that generates miss-spliced transcripts leading to Trem2 haploinsufficiency only in mice but not in humans

  16. Triggering receptor expressed on myeloid cells 2 (TREM2) knockout(-/-) mice displayed repetitive behavior and altered sociability.

  17. Transcriptome analysis revealed that our Trem2-/- mouse line (Velocigene allele) results in exaggerated Treml1 upregulation. In contrast, aberrantly high Treml1 expression was absent in the Trem2 knockout line generated by the Colonna lab and the Jackson Labs CRISPR/Cas9 Trem2 knockout line.

  18. The present study provide novel evidence that overexpression of TREM2 protects against MPTP-induced PD progression via modulation of microglial function through inhibiting TRAF6/TLR4-mediated activation of the MAPK and NF-kappaB signaling pathways.

  19. Our data establish a critical link between oAbeta1-42, a major pathological component of Alzheimer's disease and TREM2

  20. These data suggest that the Alzheimer's disease-associated TREM2 R47H variant increases risk for Alzheimer's disease by conferring a loss of TREM2 function and enhancing neuritic dystrophy around plaques.

TREM2 Antigen Profile

Antigen Summary

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with TREM2

  • triggering receptor expressed on myeloid cells 2 (TREM2) antibody
  • triggering receptor expressed on myeloid cells 2 (trem2) antibody
  • trem-like transcript 2 protein (LOC100228399) antibody
  • triggering receptor expressed on myeloid cells 2 (Trem2) antibody
  • TREM-2 antibody
  • TREM-A1 antibody
  • TREM-B1 antibody
  • TREM2 antibody
  • Trem2a antibody
  • Trem2b antibody
  • Trem2c antibody

Protein level used designations for TREM2

triggering receptor expressed on myeloid cells 2 , triggering receptor expressed on monocytes 2 , triggering receptor expressed on myeloid cells 2a , triggering receptor expressed on myeloid cells 2b , triggering receptor expressed on myeloid cells 2c

419920 Gallus gallus
748470 Pan troglodytes
100126214 Xenopus (Silurana) tropicalis
100228399 Taeniopygia guttata
719740 Macaca mulatta
54209 Homo sapiens
83433 Mus musculus
301227 Rattus norvegicus
608965 Canis lupus familiaris
100737974 Sus scrofa
506467 Bos taurus
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