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TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008].. Additionally we are shipping TREML2 Antibodies (37) and TREML2 Proteins (10) and many more products for this protein.
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Mutation of TREML2 is a major factor leading to ankylosing spondylitis for HLA-B27 (+) members in a large family and that TREML2 is also a susceptibility gene promoting the development of ankylosing spondylitis in HLA-B27 (+) individuals.
A missense variant in TREML2 was associated with a reduced risk of Alzheimer's Disease in a Han Chinese population.
Study characterized the expression of TREM genes in cerebellum and temporal cortex and determined TREML1 and TREM2 to be the only reliably expressed TREM genes in these brain regions; identified rs9357347 as a putative regulatory variant that is associated with protection from Alzheimer's disease and with increased TREML1 and TREM2 brain levels.
Its mutation plays a role in pathogenesis of Alzheimer's disease.
Missense variant in TREML2 protects against Alzheimer's disease.
TLT2 may be involved in the innate immune response based on its expression profile and the fact that it is up-regulated in response to inflammation.
analysis of an interaction between B7-H3 and TLT-2 that preferentially enhances CD8(+) T cell activation
Data do not point to a role for TREML2 as a receptor for B7-H3.
TREM2 and TREML2 play opposite roles in microglia activation
Thus, our studies identified TLT2 as an engulfment receptor for apoptotic cells.
TLT2 ligation enhances the neutrophil response to the formylated peptide FMLF, leading to increased reactive oxygen species production, degranulation, and chemotaxis
(+) T-cell effector function, possibly by ligation of TLT-2 on tumour-infiltrating CD8(+) T cells at the local tumour site.
TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003
triggering receptor expressed on myeloid cells-like 2
, triggering receptor expressed on myeloid cells
, trem-like transcript 2 protein
, triggering receptor expressed on myeloid cells-like protein 2
, triggering receptor expressed on myeloid cells-like 2a dominant