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TPBG encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion.
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Collectively, these findings demonstrate that an anti-5T4 antibody-drug conjugate reduces the fraction of cancer stem cells (CSC), and prevents local recurrence and suggest a novel therapeutic approach for patients with head and neck squamous cell carcinoma.
We obtained GWS evidence (P < 2.7 x 10(-6)) for gene-based association in the total sample with a novel locus, TPBG (P = 1.8 x 10(-6)).
In conclusion, the present study provided evidence that TPBG is involved in PDAC metastasis, and that TPBG and its associated signaling pathways may be a suitable target for pancreatic ductal adenocarcinoma therapy.
5T4 expression is mechanistically associated with the directional movement of cells through epithelial mesenchymal transition, facilitation of CXCL12 (show CXCL12 ELISA Kits)/CXCR4 (show CXCR4 ELISA Kits) chemotaxis, blocking of canonical Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) while favouring non-canonical pathway signalling
Tyrosine 325 plus the leucine-rich repeat 1 surface centered on a second exposed aromatic residue, phenylalanine 97, are essential for inhibition of Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling.
The surface expression of 5T4 marks the use of the CXCR4 (show CXCR4 ELISA Kits) rather than the CXCR7 (show CXCR7 ELISA Kits) receptor, with distinct consequences for CXCL12 (show CXCL12 ELISA Kits) exposure.
5T4 is a potential new antigen for targeted therapies such as immunotherapy in MPM, as it is overexpressed on mesothelioma cells and recognised by 5T4-specific cytotoxic T-cells.
Glycosylation and epitope mapping of the 5T4 glycoprotein oncofoetal antigen
Results sugest that 5T4 is a transient marker of human embryonic stem cell differentiation & that 5T4 phenotype, colony seeding density and culture conditions influence the maintenance of pluripotent hES cells and their differentiation to neural lineages.
there is a repertoire of CD8 T cell recognition of 5T4 in normal human donors and some candidate HLA-A*0201 epitopes have been identified
5T4 overexpression in newborn olfactory bulb interneurons facilitates their dendritic arborization even under a sensory input-deprived condition.
molecular interaction of 5T4 and CXCR4 (show CXCR4 ELISA Kits) occurring at the cell surface which directly facilitates the biological response to CXCL12 (show CXCL12 ELISA Kits)
Spry4 and Tpbg/5T4 were detected in Kit-immunoreactive cells only in Kit(K641E), but not in Kit(WT/WT) animals.
5T4 glycoprotein expression is associated with early differentiative events of embryonic stem cells
A limited expression profile of 5T4 may contribute to the migration of actively cycling, undifferentiated epithelial progenitor cells during embryogenesis
Because 5T4 is known to interact with actin cytoskeleton, these observations suggest that 5T4 is involved in the formation or maintenance of strata-specific dendritic ramification or synaptic connection of subsets of local interneurons.
E-cadherin (show CDH1 ELISA Kits) protein stabilizes cortical actin cytoskeletal arrangement in embryonic stem cells, and this can prevent cell surface localization of the promigratory 5T4 antigen.
This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein.
5T4 oncofetal antigen
, 5T4 oncofetal trophoblast glycoprotein
, 5T4 oncotrophoblast glycoprotein
, trophoblast glycoprotein
, Trophoblast glycoprotein
, trophoblast glycoprotein-like