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TPH2 encodes a member of the pterin-dependent aromatic acid hydroxylase family. Additionally we are shipping Tryptophan Hydroxylase 2 Antibodies (178) and Tryptophan Hydroxylase 2 Proteins (12) and many more products for this protein.
Showing 8 out of 29 products:
These findings indicate that TPH1 (show TPH1 ELISA Kits), TPH2 (show TDO2 ELISA Kits), and SLC6A4 (show SLC6A4 ELISA Kits) variants moderate the subjective effects of cocaine in non-treatment-seeking cocaine-dependent participants.
results provide new evidence for the role of regulatory genetic variants that could modulate human TPH2 (show TDO2 ELISA Kits) expression in the antidepressant response to fluoxetine.
This study firstly demonstrated evidence for an association between aberrant cortical folding in the PFC (show CFP ELISA Kits) and ACC (show ACACA ELISA Kits) and TPH2 (show TDO2 ELISA Kits) polymorphism gene related to the pathophysiology of major depressive disorder.
social anxiety disorder entails an overactive presynaptic serotonergic system that, in turn, seems functionally influenced by the TPH2 (show TDO2 ELISA Kits) G-703T polymorphism in emotionally relevant brain regions
Tryptophan hydroxylase (show TPH1 ELISA Kits) synthesizes Serotonin and is over-expressed in Suicides.TPH2 mRNA was greater in Suicide Nonsmokers than Suicide Smokers.The absence of altered TPH2 (show TDO2 ELISA Kits) expression in non-suicide smokers suggests no pharmacological effect of Smoking.
This study shown the significant results were found with TPH2 (show TDO2 ELISA Kits) rs4570625 involved with fast visual processing as assessed by metacontrast.
Genetic variation in TPH2 (show TDO2 ELISA Kits) is associated with antidepressant response and may also interact with childhood trauma to influence outcome of antidepressant treatment.
2-way interaction between TPH2 (show TDO2 ELISA Kits) rs4290270 and general traumas revealed that TT homozygotes with history of general traumas had an increased risk for suicide attempt. 3-way interaction of general traumas, TPH2 (show TDO2 ELISA Kits) rs4290270 and ADARB1 (show ADARB1 ELISA Kits) rs4819035 indicated that highest predisposition to suicide attempt was observed in individuals who experienced general traumas and were TT homozygote for rs4290270 and TT homozygote for rs4819035.
The catalytic domain of TPH1 (show TPH1 ELISA Kits) shares a sequence identity of 81% with TPH2 (show TDO2 ELISA Kits). Despite the high sequence identity, differences in the kinetic parameters of the isoforms have been identified; i.e., only TPH1 (show TPH1 ELISA Kits) displays substrate tryptophan inhibition.
results confirm the role of TPH1 (show TPH1 ELISA Kits), TPH2 (show TDO2 ELISA Kits), 5HT2A, CRHR1 (show CRHR1 ELISA Kits) and ACP1 (show ACP1 ELISA Kits) variants in the risk of suicidal behavior.
TPH2 5'- and 3'-regulatory polymorphisms are differentially associated with hypothalamo-pituitary-adrenal axis function and self-injurious behavior in rhesus monkeys
The present study supports the hypothesis that rearing experience and rhTPH2 A2051C interact to influence central 5-HT (show DDC ELISA Kits) metabolism, HPA (show HPSE ELISA Kits) axis function, and aggressive behaviors
Study identified 17 single nucleotide polymorphisms; 3'-UTR (show UTS2R ELISA Kits) polymorphisms were significantly associated with HPA (show HPSE ELISA Kits) axis activity, especially 2051A>C, which was strikingly correlated with plasma cortisol level in the morning only.
functional significance of two nonsynonymous single nucleotide polymorphisms (SNPs) (C74A and G223A) in rhesus monkey TPH2
Association of TPH2 SNP with neuroticism in captive and wild-born chimpanzees living in Japan and Guinea, respectively, was tested.
these results suggest that fish prefer swimming in conditions that elicits lower activity in tph2 serotonergic neurons in the rostral raphe.
tphR is expressed in serotonergic raphe neurons, similar to tph (show TPH1 ELISA Kits) genes in mammalian species; tphR is also expressed in the pineal organ where it is likely to be involved in the pathway leading to synthesis of melatonin
The Tph2(-/-) mice showed deficiency in brain 5-HT (show DDC ELISA Kits) increases the functional coupling of 5-HT1AARs to GIRK channels without a concomitant increase in 5-HT1AAR and/or GIRK channel density level.
Results indicate that Tph2 knockout affected the ability of olfactory recognition rather than olfactory discrimination. For the first time, reproductive experiences have been shown to mitigate the disruptive effect of Tph2 knockout on the sexual olfactory preference of female mice. Furthermore, ERalpha (show ESR1 ELISA Kits) and OTR (show OXTR ELISA Kits) activation might constitute the neural substrates that are involved involved in the facilitative mechanisms.
This study demonstrated that tryptophan hydroxylase 2 Deficiency Causes Hyperactivity, Circadian Disruption, and Elimination of Siestas.
No substantial differences in any parameter reflecting their firing activity both in vivo and in vitro were found in raphe nucleus 5-HT (show DDC ELISA Kits) neurons of Tph2-/-, Tph2+/-, and Tph2+/+ mice
the C1473G polymorphism in the Tph-2 gene considerably influenced the changes in the expression patterns of genes involved in the regulation of neurogenesis and neural apoptosis induced by chronic ethanol treatment.
The results of this study suggests that Tph2(-/-) mice is a useful preclinical model to assess the role of 5-HT (show DDC ELISA Kits)-dependent mechanisms in psychostimulants action.
both Tph2(-/-) male and female mice were resilient to chronic mild stress-induced hyperlocomotion
1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin (show LEP ELISA Kits) genes: implication for behavioral influences of vitamin D.
Litters born to and reared by TPH2-/- mothers showed decreased survival, lower weaning weights and increased cannibalization.
Decreased TPH2 activity cannot be considered a reliable predisposition factor for impaired emotional behavior: in conditions of reduced serotonin production a lowered serotonin degradation rate contributes to the maintenance of brain serotonin
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.
neuronal tryptophan hydroxylase
, tryptophan 5-hydroxylase 2
, tryptophan 5-monooxygenase 2
, tryptophan hydroxylase-2
, tryptophan hydroxylase 2
, tryptophan 5-hydroxylase 2-like
, tryptophan hydroxylase R