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Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Additionally we are shipping WARS2 Antibodies (20) and many more products for this protein.
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we found a compound heterozygous genotype of the mitochondrial tryptophanyl-tRNA synthetase (WARS2) gene, comprising a nonsense mutation (c.325delA, p.Ser109Alafs*15), which very likely entails nonsense-mediated mRNA decay and a missense mutation
Here we substantially extend and consolidate the symptomatology of WARS2 by presenting a patient with severe infantile-onset leukoencephalopathy, profound intellectual disability, spastic quadriplegia, epilepsy, microcephaly, short stature, failure to thrive, cerebral atrophy, and periventricular white matter abnormalities
first genome-wide scan for selection in Inuit from Greenland. A region, with a deeply divergent haplotype that is closely related to the sequence in the Denisovan genome contains two genes, WARS2 and TBX15 (show TBX15 Proteins). our study suggests a complex multi-factorial regulation of TBX15 (show TBX15 Proteins) and WARS2. We show that the introgressed region is associated with regional changes in methylation and expression levels
tandem promoters provide a dual system to regulate expression and alternative splicing of human TrpRS (show WARS Proteins) in vivo
Mutations located at the appended beta1-beta2 hairpin and the AIDQ sequence of human TrpRS (show WARS Proteins) switch this enzyme to a tRNA-dependent mode in the tryptophan activation step.
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described.
tryptophanyl tRNA synthetase 2, mitochondrial
, tryptophanyl-tRNA synthetase, mitochondrial-like
, tryptophan--tRNA ligase, mitochondrial
, tryptophanyl-tRNA synthetase, mitochondrial
, tryptophan tRNA ligase 2, mitochondrial
, tryptophan-tRNA ligase
, mitochondrial tryptophanyl-tRNA synthetase 2
, tryptophanyl tRNA synthetase 2 (mitochondrial)