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Tubulin is the major constituent of microtubules. Additionally we are shipping Tubulin, beta 8 Proteins (6) and many more products for this protein.
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This TUBB8 variant in one infertile individual was absent in the 100 fertile females and was predicted to be highly damaging to the function of the TUBB8 protein by SIFT and PolyPhen-2.
A homozygous mutation of TUBB8 associated with complete cleavage failure in fertilized eggs.
TUBB8 mutations occur in a high proportion of infertile women with oocyte maturation arrest.
The results not only emphasize the important role of TUBB8 in oocyte maturation, fertilization and early embryonic development but they also provide a basis for determining the genetic variations in TUBB8 as a potential additional criterion for evaluating the quality of patients' functional PB1 oocytes.
9 novel TUBB8 mutations and phenotypes in patients with oocyte maturation arrest were reported.
TUBB8 mutations have dominant-negative effects that disrupt microtubule behavior and oocyte meiotic spindle assembly and maturation, causing female infertility.
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.
HSA10p15 beta-tubulin 4Q
, class VIII beta-tubulin
, tubulin beta-8 chain