Tubulin Polymerization Promoting Protein Proteins (Tppp)

Human Tubulin Polymerization Promoting Protein (Tppp) interaction partners

1. The objective of this paper is to highlight a critical point of a recently published Skoufias's paper in which the crucial role of the microtubules in TPPP/p25 dimerization leading to microtubule bundling was suggested.

2. This study demonstrated that the AAV9-mediated p25 overexpression mouse model, which is a practical model exhibiting neurodegeneration-like pathological and behavioral changes.

3. The knowledge accumulated so far underlines the key roles of the multifunctional TPPP/p25 in both physiological and diverse pathological processes, consequently its validation as drug target sorely needs a new innovative strategy that is briefly reviewed here.

4. TPPP may have a role in poor prognosis in hepatocellular carcinoma

5. the central folded domain of TPPP/p25 following binding to microtubules can drive s homotypic protein-protein interactions leading to bundled microtubules.

6. Results reveal a link between p25 (show LCN2 Proteins) and BACE1 (show BACE Proteins) in Alzheimer disease (AD) brains and suggest that upregulated Cdk5 (show CDK5 Proteins) activation by p25 (show LCN2 Proteins) accelerates AD pathogenesis by enhancing BACE1 (show BACE Proteins) activity via phosphorylation.

7. Epigenetic changes in TPPP, in combination with experiences of maltreatment, may confer risk for depression in children.

8. suggest that the zinc as a specific divalent cation could be involved in the fine-tuning of the physiological TPPP/p25 level counteracting both the enrichment and the lack of this protein leading to distinct central nervous system diseases

9. results suggest that ROCK regulates beta-catenin stability in cells via preventing TPPP1-mediated inhibition of HDAC6 activity, to reduce its acetylation and degradation via phosphorylation by CK1 and GSK3beta

10. GSK3 promotes the mitochondrial translocation of p53 (show TP53 Proteins), enabling its interaction with Bcl2 (show BCL2 Proteins) to allow Bax (show BAX Proteins) oligomerization and the subsequent release of cytochrome C (show CYCS Proteins).

Mouse (Murine) Tubulin Polymerization Promoting Protein (Tppp) interaction partners

1. The present study provides additional support for roles for TPPP in the etiology of depression following early adversity.

2. These results support an essential role for TPPP/p25 in oligodendrocyte differentiation likely via rearrangement of the microtubule system during the process elongation prior to the onset of myelination.

3. LIMK1 phosphorylation of p25 blocks p25 activity, thus promoting microtubule disassembly.

4. A pathway was discovered by which p25 (show CDK5R1 Proteins) and cdk5 (show CDK5 Proteins) increases the amyloidogenic processing of amyloid precursor protein (show APP Proteins).