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TUSC2 is a highly conserved lung cancer candidate gene.
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Human Polyclonal TUSC2 Primary Antibody for ELISA - ABIN451824
Deng, Kawashima, Wu, Jayachandran, Xu, Minna, Roth, Ji et al.: Synergistic tumor suppression by coexpression of FUS1 and p53 is associated with down-regulation of murine double minute-2 and activation of the apoptotic protease-activating factor 1-dependent ... in Cancer research 2007
these findings show that the combination of TUSC2-erlotinib induces additional novel vulnerabilities that can be targeted with Auranofin.
Data show that TUSC2 is a direct target of miR (show MLXIP Antibodies)-584, which is transcriptionally regulated by TWIST1 (show TWIST1 Antibodies).
FOXP1 (show FOXP1 Antibodies), TP53INP1 (show TP53INP1 Antibodies), TNFAIP3 (show TNFAIP3 Antibodies), and TUSC2 were identified as miR (show MLXIP Antibodies)-19a targets.
The therapeutic activity of TUSC2 could extend the use of erlotinib to lung cancer patients with wildtype EGFR (show EGFR Antibodies).
TUSC2P and TUSC2 3'-UTR (show UTS2R Antibodies) expression inhibits cell proliferation, survival, migration, invasion and colony formation, and increases tumor cell death. TUSC2P and TUSC2 3'-UTR (show UTS2R Antibodies) bind to miRNAs and arrest their functions, leading to increased TUSC2 translation.
The tumor suppressor gene TUSC2 (FUS1) sensitizes NSCLC to the AKT (show AKT1 Antibodies) inhibitor MK2206 in LKB1 (show STK11 Antibodies)-dependent manner.
RNA sequence elements in FUS1 (show FUS Antibodies) UTRs that regulate FUS1 (show FUS Antibodies) protein express were identified.
Absence of tumor suppressor FUS1 (show FUS Antibodies) protein expression is associated with bone and soft tissue sarcomas.
Data show that the recombinant FUS1 (show FUS Antibodies) plasmid has been successfully cloned, which allows highly efficient FUS1 (show FUS Antibodies) expression in E.coli strain Rosetta (DE3)2 plys.
The goal of this study was to analyze possible involvement of TUSC2 in malignant pleural mesothelioma.
results suggest that Tusc2 acts as a positive regulator of RANKL (show TNFSF11 Antibodies)-mediated osteoclast differentiation
Fus1 achieves its protective role in inflammation, autoimmunity, and cancer via the regulation of mitochondrial calcium and calcium-coupled parameters.
This gene is a highly conserved lung cancer candidate gene. No other information about this gene is currently available.
tumor suppressor candidate 2
, PDGFA associated protein 2
, PDGFA-associated protein 2
, fus-1 protein
, fusion 1 protein
, lung cancer candidiate, FUS