Two Pore Segment Channel 2 (TPCN2) ELISA Kits

TPCN2 encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. Additionally we are shipping TPCN2 Antibodies (39) and TPCN2 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Rat TPCN2 TPCN2 309139  
TPCN2 219931 Q8NHX9
TPCN2 233979 Q8BWC0
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Top TPCN2 ELISA Kits at antibodies-online.com

Showing 2 out of 4 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human
  96 Tests Log in to see 11 to 18 Days
$589.86
Details
Mouse
  96 Tests Log in to see 11 to 18 Days
$589.86
Details

More ELISA Kits for TPCN2 Interaction Partners

Zebrafish Two Pore Segment Channel 2 (TPCN2) interaction partners

  1. Data suggest a novel function for NAADP/TPC2-mediated Ca(2+) signaling in the development, coordination, and maturation of the spinal network in zebrafish embryos.

  2. localized calcium (Ca(2+)) release via TPC2 might trigger the generation of more global Ca(2+) release from the sarcoplasmic reticulum via Ca(2+)-induced Ca(2+) release.

  3. TPC2-mediated Ca(2+) release from lysosomes may act upstream from RyR- and IP 3R-mediated Ca(2+) release, suggesting that the former might initiate the SR-mediated Ca(2+)-induced-Ca(2+)-release essential for SMC myogenesis and function.

Human Two Pore Segment Channel 2 (TPCN2) interaction partners

  1. PI(3,5)P2-binding site in hTPC2 identified at positively charged amino acids (K203, K204, and K207) in the linker between transmembrane helices S4 and S5 and by S322 in the cytosolic extension of S6 and protein-lipid interface upon mutations of residues within the lipid-binding pocket had neither an effect on the binding behavior nor on the channel's lipid sensitivity.

  2. TPC2 polymorphisms are associated with a hair pigmentation.

  3. Data (including data from studies using tissue from knockout mice) suggest that beta-adrenergic stimulation of pancreas leads to glucagon secretion by hierarchy of calcium signaling in glucagon-secreting cell; such signaling is initiated by cAMP-induced TPC2-dependent calcium release from acidic stores and is further amplified by calcium release from endoplasmic reticulum.

  4. the divergent pore regions from human TPC2, a two-domain channel that holds a key intermediate position in the evolution of voltage-gated ion channels, were characterized.

  5. The ion selectivity of Arabidopsis thaliana TPC1 was compared with the selectivity of human TPC2. HsTPC2 was confirmed as a Na(+)-selective channel activated by phosphatidylinositol 3,5-bisphosphate. The ion permeability ratios of HsTPC2 and its mutants were calculated.

  6. These findings indicate potential differential regulation of signaling processes by TPC1 and TPC2 in breast cancer cells.

  7. Results demonstrated the unique bell-shaped regulation of hTPC2 channel activity by [NAADP] and that channel activity is modulated by PKA phosphorylation at position S666.

  8. TPC2 regulates pigmentation through two fundamental determinants of melanosome function: pH and size.

  9. rs1551305 single nucleotide polymorphism is associated with type 2 diabetes risk.

  10. Results show that PDGs use previously unknown mechanisms of membrane dynamics and content exchange that are regulated by TPC2.

  11. Here, using live cell imaging, the authors obtained evidence that in contrast to the new model, ebolavirus enters cells through endolysosomes that contain both NPC1 and TPC2.

  12. Studies suggest that both two-pore channels TPC1 and TPC2 as nicotinic acid adenine dinucleotide phosphate (NAADP) targets.

  13. TPC2 is thus a potential drug target within a pathogenic LRRK2 cascade that disrupts Ca(2+)-dependent trafficking in Parkinson disease

  14. SNPs within Tpcn2 are associated with fasting insulin in humans.

  15. NAADP induced marked Ca(2+) transients in HEK293 cells that stably coexpressed hTPC2 with hTPC1 or cTPC3, but failed to evoke any such response in cells that coexpressed interacting hTPC2 and rTPC3 subunits

  16. TPC2, but not TPC1, caused a proliferation of endolysosomal structures, dysregulating intracellular trafficking, and cellular pigmentation.

  17. These results demonstrate that a VEGFR2/NAADP/TPC2/Ca(2+) signaling pathway is critical for VEGF-induced angiogenesis

  18. TPC1 and TPC2 proteins play a key role in Ebola virus infection and may be effective targets for antiviral therapy.

  19. Notably, NAADP-mediated Ca(2+) release in intact cells is regulated by Mg(2+), PI(3,5)P2, and P38/JNK kinases, thus paralleling regulation of TPC2 currents.

  20. These results provide strong evidence for modulation of store-operated Ca(2+) entry by TPC2 involving de novo association between TPC2 and STIM1, as well as Orai1, in human cells.

Mouse (Murine) Two Pore Segment Channel 2 (TPCN2) interaction partners

  1. Under normal Mg(2+) conditions, TPC2 promotes osteoclastogenesis. Under low-Mg(2+) conditions, TPC2 inhibited, rather than promoted, the osteoclast differentiation, and the phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) signaling pathway played a role in the TPC2 activation under low-Mg(2+) conditions.

  2. Data (including data from studies using tissue from knockout mice) suggest that beta-adrenergic stimulation of pancreas leads to glucagon secretion by hierarchy of calcium signaling in glucagon-secreting cell; such signaling is initiated by cAMP-induced Tpc2-dependent calcium release from acidic stores and is further amplified by calcium release from endoplasmic reticulum.

  3. Study identifies two-pore channel 2 (TPC2) as the first reported melanosomal cation conductance by directly patch-clamping skin and eye melanosomes. TPC2 is shown to function as a negative regulator of pigmentation by increasing melanosome membrane potential and melanosome acidity.

  4. High TPC2 expression is associated with lung metastasis in breast cancer.

  5. Electron micrographs of hearts from TPC1/TPC2 double knockout mice showed that cardiomyocytes contained large numbers of immature lysosomes compared to wild-type mice.

  6. observations define a role for NAADP and TPC2 at lysosomal/sarcoplasmic reticulum junctions as unexpected but major contributors in the acute actions of beta-adrenergic signaling in the heart

  7. TPC2 plays a crucial role in trafficking in the endolysosomal degradation pathway and in fatty liver disease.

  8. Genetic ablation of endolysosomal TPC1 or TPC2 channels attenuates glucose- and sulfonylurea-induced membrane currents, depolarization, cytoplasmic Ca2+ signals, and insulin secretion in pancreatic beta cells.

  9. Tpcn2 knockout mice demonstrated a significant decrease in fasting glucose levels and insulin response to a glucose challenge.

  10. Mice lacking TPC2 display muscle atrophy and altered autophagy.

  11. It was concluded that Tpcn1/2(-/-) mice show mature-onset obesity due to reduced lipid availability and use, and a defect in beta-adrenergic receptor signaling, leading to impaired thermogenic activity, in brown adipose tissue.

  12. These results demonstrate that a VEGFR2/NAADP/TPC2/Ca(2+) signaling pathway is critical for VEGF-induced angiogenesis

  13. Findings indicate that TPC2 have important but distinct roles from TPC1 in the endo-lysosomal pathway.

  14. TPC2 signaling inhibits embryonic stem cell entry to early neural progenitors, but is required for late neuronal differentiation.

  15. We find alterations in two-pore calcium channel protein expression, with loss of presenilin preventing the formation of a high molecular weight species of TPC1 and TPC2.

  16. Study identifies an endolysosomal ATP-sensitive Na channel - a complex formed by two-pore channels TPC1 and TPC2; channel complex detects nutrient status, becomes constitutively open upon nutrient removal and mTOR translocation off the lysosomal membrane, and controls the lysosome's membrane potential, pH stability, and amino acid homeostasis.

  17. TPC2 is a novel critical molecule for osteoclastogenesis.

  18. Study finds by direct patch-clamp analysis of endolysosomal membranes that PI(3,5)P2 specifically activates TPCs and, unexpectedly, that nicotinic acid adenine dinucleotide phosphate does not. TPC1 and TPC2-mediated currents are selective for Na+, which is the predominant cation in the lysosome.

  19. proteins mediate a key NAADP-regulated tissue response brought about by agonist activation of a cell surface recepto

  20. analysis of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes

TPCN2 Antigen Profile

Antigen Summary

This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.

Gene names and symbols associated with TPCN2

  • two pore segment channel 2 (tpcn2) antibody
  • two pore segment channel 2 (Tpcn2) antibody
  • two pore segment channel 2 (TPCN2) antibody
  • two pore segment channel 2 L homeolog (tpcn2.L) antibody
  • two pore calcium channel protein 2 (LOC100444397) antibody
  • BC025890 antibody
  • D830047E22Rik antibody
  • fi42c05 antibody
  • im:7140344 antibody
  • MGC115225 antibody
  • SHEP10 antibody
  • TPC2 antibody
  • wu:fi42c05 antibody
  • zgc:152898 antibody

Protein level used designations for TPCN2

two pore calcium channel protein 2 , voltage-dependent calcium channel protein TPC2 , two pore segment channel 2 , two pore calcium channel protein 2-like , two-pore calcium channel protein 2

GENE ID SPECIES
777614 Danio rerio
309139 Rattus norvegicus
423141 Gallus gallus
483683 Canis lupus familiaris
734733 Xenopus laevis
747605 Pan troglodytes
100444397 Pongo abelii
100492057 Xenopus (Silurana) tropicalis
100523421 Sus scrofa
100565414 Anolis carolinensis
219931 Homo sapiens
233979 Mus musculus
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