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The protein encoded by PTPN4 is a member of the protein tyrosine phosphatase (PTP) family.
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Deletion of PTPN4 has been reported in monozygotic twins with a Rett syndrome-like phenotype.
The physiologically active PTPN4 two-domain (the PDZ and the phosphatase domains) adopts a predominant compact conformation in solution. PDZ ligand binding restores the catalytic competence of PTPN4 disrupting the transient interdomain communication.
These findings suggest that PTPN4 negatively regulates cell proliferation and motility through dephosphorylation of CrkI.
PTPN4 is dispensable for T cell development and/or T cell effector functions.
our results provide new insight into the TLR4 (show TLR4 Antibodies) pathway and identify PTPN4 as a specific inhibitor of TRIF (show RNF138 Antibodies)-dependent TLR4 (show TLR4 Antibodies) pathway.
Tyrosine dephosphorylation events regulated by PTPMEG are important for both motor learning and cerebellar synaptic plasticity.
PTPN3 and PTPN4 are dispensable for TCR signal transduction.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation.
, megakaryocyte phosphatase
, megakaryocyte protein-tyrosine phosphatase
, protein tyrosine phosphatase MEG1
, protein-tyrosine phosphatase MEG1
, tyrosine-protein phosphatase non-receptor type 4
, testis-enriched protein tyrosine phosphatase
, protein tyrosine phosphatase non-receptor type 4
, protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)