anti-Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Antibodies

The protein encoded by TDP1 is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. Additionally we are shipping TDP1 Proteins (14) and TDP1 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TDP1 55775 Q9NUW8
TDP1 104884  
TDP1 314380 Q4G056
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Top anti-TDP1 Antibodies at antibodies-online.com

Showing 10 out of 103 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), IP, IHC, PLA, WB Immunohistochemistry-Paraffin: TDP1 Antibody [ABIN2570872] - Section of human ovarian carcinoma. Dilution: 1:1,000 (0.2ug/ml). 0.1 mL Log in to see 7 to 9 Days
$556.31
Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: Tdp1 Sample Type: Mouse Lung lysates Antibody Dilution: 1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Tdp1 Antibody Titration: 1.0 ug/ml Positive Control: Mouse Brain 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated EIA, IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Human Mouse Un-conjugated ELISA, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (92.62 KDa) . Dilution: 1:500~1000 Detection limit for recombinant GST tagged TDP1 is approximately 0.1ng/ml as a capture antibody. 100 μg Log in to see 8 to 11 Days
$461.00
Details
Human Mouse Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$315.00
Details
Human Mouse Un-conjugated ELISA, IHC, IHC (p), WB Human Small Intestine (formalin-fixed, paraffin-embedded) stained with antibody ABIN462272 followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. Human Placenta (formalin-fixed, paraffin-embedded) stained with antibody ABIN462272 followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. 50 μL Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated IF, IP, WB Immunoprecipitation of TDP1 transfected lysate using anti-TDP1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with TDP1 purified MaxPab mouse polyclonal antibody (B01P) . Western Blot analysis of TDP1 expression in transfected 293T cell line by TDP1 MaxPab polyclonal antibody.<br><br>Lane 1: TDP1 transfected lysate(68.40 KDa).<br>Lane 2: Non-transfected lysate.<br> 100 μL Log in to see 11 to 12 Days
$425.71
Details
Guinea Pig Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Mouse Un-conjugated WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TDP1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-TDP1. 0.1 mL Log in to see Available
$482.90
Details

Top referenced anti-TDP1 Antibodies

  1. Human Polyclonal TDP1 Primary Antibody for ELISA, WB - ABIN565920 : Katyal, el-Khamisy, Russell, Li, Ju, Caldecott, McKinnon: TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo. in The EMBO journal 2007 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal TDP1 Primary Antibody for IHC (p), IP - ABIN257087 : Perego, Cossa, Tinelli, Corna, Carenini, Gatti, De Cesare, Ciusani, Zunino, Luison, Canevari, Zaffaroni, Beretta: Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition. in Biochemical pharmacology 2011 (PubMed)
    Show all 2 Pubmed References

More Antibodies against TDP1 Interaction Partners

Human Tyrosyl-DNA Phosphodiesterase 1 (TDP1) interaction partners

  1. We found the rs942190 GG genotype of TDP1 to be associated with relatively poor survival among small-cell lung cancer patients. Further investigation is needed to confirm the result and to determine whether this genotype may be a predictive marker for treatment efficacy of DNA topoisomerase inhibitors

  2. this study identifies the importance of TDP1 as a novel determinant of response to CNDAC across various cancer types (especially non-small cell lung cancers), and demonstrates the differential involvement of BRCA2 (show BRCA2 Antibodies), PARP1 (show PARP1 Antibodies), and TDP1 in the cellular responses to CNDAC, AraC, and CPT (show CHPT1 Antibodies)

  3. Data indicate that the initial step of tyrosyl-DNA phosphodiesterase 1 (Tdp1) interaction with DNA includes binding of Tdp1 to the DNA ends followed by the 3'-nucleosidase reaction.

  4. Data indicate a molecular basis for DNA 3'-end processing by tyrosyl-DNA phosphodiesterase (Tdp1).

  5. Expression of human Tdp1HisnucAla and Tdp1HisgabAsn mutants results in stabilization of the covalent TDP1-DNA intermediate and induces cytotoxicity.

  6. We show that two genes, TDP1, a tyrosyl-DNA-phosphdiesterase, and TAF12 (show TAF12 Antibodies), an RNA polymerase II (show 0 Antibodies) TATA-box binding factor, cause CIN (show PDXP Antibodies) when overexpressed in human cells. Using SDL screens in yeast, we identified a set of genes that when deleted specifically kill cells with high levels of Tdp1

  7. TDP1 participation in human non-homologous end joining (NHEJ) is mediated by interaction with XLF (show NHEJ1 Antibodies), and that TDP1-XLF (show NHEJ1 Antibodies) interactions and subsequent NHEJ events are regulated by phosphorylation of TDP1-S81.

  8. Mutations in TDP1 and APTX have been linked to Spinocerebellar ataxia with axonal neuropathy (SCAN1) and Ataxia-ocular motor apraxia 1 (AOA1), respectively, while mutations in PNKP are considered to be responsible for Microcephaly with seizures (MCSZ) and Ataxia-ocular motor apraxia 4 (AOA4).

  9. The data obtained suggest that PARP1 (show PARP1 Antibodies) and TDP1 bind in an antiparallel orientation; the N-terminus of the former protein interacts with the C-terminal domain of the latter.

  10. Tyrosyl-DNA-phosphodiesterase I (TDP1) participates in the removal and repair of stabilized-Top2alpha cleavage complexes in human cells.

Mouse (Murine) Tyrosyl-DNA Phosphodiesterase 1 (TDP1) interaction partners

  1. These findings provide evidence for TDP1 as a novel mitochondrial enzyme.

  2. The interaction with Lig3alpha is promoted by serine 81 that is located within a putative S/TQ site in the N-terminus domain of TDP1.

  3. Data indicate that TDP1 is required for neural homeostasis and reveal a widespread requisite for TDP1 function in response to acutely elevated levels of DNA topoisomerase I (Top1 (show TOP1 Antibodies))-associated DNA strand breaks.

  4. This study provides a direct demonstration that Tdp1 repairs Topo I (show TOP1 Antibodies) covalent lesions in vivo and suggests that spinocerebellar ataxia with axonal neuropathy (SCAN1 (show CANT1 Antibodies)) arises from the recessive neomorphic mutation H493R.

  5. Tdp1(-/-) fibroblasts exhibited deficiencies in processing 3'-phosphotyrosyl single-strand breaks and 3'-phosphoglycolate double-strand breaks, but not 3 (show CNOT3 Antibodies)'-phosphoglycolate single-strand breaks.

Arabidopsis thaliana Tyrosyl-DNA Phosphodiesterase 1 (TDP1) interaction partners

  1. AtTDP plays a clear role in the repair of topoisomerase I (show TOP1 Antibodies)-DNA complexes.

TDP1 Antigen Profile

Protein Summary

The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.

Gene names and symbols associated with TDP1

  • tyrosyl-DNA phosphodiesterase 1 (TDP1) antibody
  • tyrosyl-DNA Phosphodiesterase (Tdp1) (Tc00.1047053511191.10) antibody
  • tyrosyl-DNA phosphodiesterase 1 (Tdp1) antibody
  • tyrosyl-DNA phosphodiesterase 1 L homeolog (tdp1.L) antibody
  • tyrosyl-DNA phosphodiesterase 1 (tdp1) antibody
  • tyrosyl-DNA phosphodiesterase-like protein (TDP1) antibody
  • tyrosyl-DNA phosphodiesterase 1 (PTRG_11198) antibody
  • tyrosyl-DNA phosphodiesterase 1 (MCYG_02121) antibody
  • tyrosyl-DNA phosphodiesterase 1 (MGYG_03035) antibody
  • 2810481F14Rik antibody
  • 4921509N21Rik antibody
  • AI838772 antibody
  • AW493413 antibody
  • E430034L06Rik antibody
  • F8M21.60 antibody
  • F8M21_60 antibody
  • MGC83708 antibody
  • MLZ-501 antibody
  • SCAN1 antibody
  • TDP1 antibody
  • tyrosyl-DNA phosphodiesterase 1 antibody

Protein level used designations for TDP1

tyr-DNA phosphodiesterase 1 , tyrosyl-DNA Phosphodiesterase (Tdp1) , protein expressed in male leptotene and zygotene spermatocytes 501 , tyrosyl-DNA phodphodiesterase 1 , tyrosyl-DNA phosphodiesterase 1 , tyrosyl-DNA phosphodiesterase 1-like , Tyrosyl-DNA phosphodiesterase 1-like protein

GENE ID SPECIES
55775 Homo sapiens
3534433 Trypanosoma cruzi strain CL Brener
104884 Mus musculus
314380 Rattus norvegicus
423403 Gallus gallus
446983 Xenopus laevis
453096 Pan troglodytes
517053 Bos taurus
571485 Danio rerio
695338 Macaca mulatta
734106 Xenopus (Silurana) tropicalis
831369 Arabidopsis thaliana
6349511 Pyrenophora tritici-repentis Pt-1C-BFP
9229242 Arthroderma otae CBS 113480
10030819 Arthroderma gypseum CBS 118893
100388128 Callithrix jacchus
100432320 Pongo abelii
100593301 Nomascus leucogenys
100724667 Cavia porcellus
100062463 Equus caballus
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