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TDP1 Products

(Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

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The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq, Jul 2008].

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Featured TDP1 Categories

TDP1 Antibodies

High quality antibodies with extensive validation data.

TDP1 ELISA Kits

Reliable ELISA kits for a wide range of species.

TDP1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TDP1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IF, IP, WB
Validations
  • (4)
Cat. No. ABIN949469
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, IP, WB
Validations
  • (3)
Cat. No. ABIN7174129
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ICC, IF, IHC (p), WB
Validations
  • (3)
Cat. No. ABIN2857076
Quantity 100 μL
Datasheet Datasheet

Recommended TDP1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6960333
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN5564588
Quantity 96 tests
Datasheet Datasheet

Recommended TDP1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1322434
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN2132102
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3096148
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our TDP1 products

Meisenberg, Gilbert, Chalmers, Haley, Gollins, Ward, El-Khamisy: "Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan." in: Molecular cancer therapeutics, Vol. 14, Issue 2, pp. 575-85, (2015) (PubMed).

Das, Huang, Murai, Rehman, Amé, Sengupta, Das, Majumdar, Zhang, Biard, Majumder, Schreiber, Pommier: "PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage." in: Nucleic acids research, Vol. 42, Issue 7, pp. 4435-49, (2014) (PubMed).

Katyal, Lee, Nitiss, Downing, Li, Shimada, Zhao, Russell, Petrini, Nitiss, McKinnon: "Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes." in: Nature neuroscience, Vol. 17, Issue 6, pp. 813-21, (2014) (PubMed).

Perego, Cossa, Tinelli, Corna, Carenini, Gatti, De Cesare, Ciusani, Zunino, Luison, Canevari, Zaffaroni, Beretta: "Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition." in: Biochemical pharmacology, Vol. 83, Issue 1, pp. 27-36, (2011) (PubMed).

Hawkins, Subler, Akopiants, Wiley, Taylor, Rice, Windle, Valerie, Povirk: "In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation." in: DNA repair, Vol. 8, Issue 5, pp. 654-63, (2009) (PubMed).

Das, Antony, Gupta, Dexheimer, Redon, Garfield, Shiloh, Pommier: "Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK." in: The EMBO journal, Vol. 28, Issue 23, pp. 3667-80, (2009) (PubMed).

Igaz, Kwong, Chen-Plotkin, Winton, Unger, Xu, Neumann, Trojanowski, Lee: "Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies." in: The Journal of biological chemistry, Vol. 284, Issue 13, pp. 8516-24, (2009) (PubMed).

Katyal, el-Khamisy, Russell, Li, Ju, Caldecott, McKinnon: "TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo." in: The EMBO journal, Vol. 26, Issue 22, pp. 4720-31, (2007) (PubMed).

Takahashi, Tada, Igarashi, Koyama, Date, Yokoseki, Shiga, Yoshida, Tsuji, Nishizawa, Onodera: "Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate ends." in: Nucleic acids research, Vol. 35, Issue 11, pp. 3797-809, (2007) (PubMed).

Synonyms and alternative names related to TDP1

tyrosyl-DNA phosphodiesterase 1 (TDP1), tyrosyl-DNA Phosphodiesterase (Tdp1) (Tc00.1047053511191.10), tyrosyl-DNA phosphodiesterase 1 (Tdp1), tyrosyl-DNA phosphodiesterase 1 L homeolog (tdp1.L), tyrosyl-DNA phosphodiesterase 1 (tdp1), tyrosyl-DNA phosphodiesterase-like protein (TDP1), tyrosyl-DNA phosphodiesterase 1 (PTRG_11198), tyrosyl-DNA phosphodiesterase 1 (MCYG_02121), tyrosyl-DNA phosphodiesterase 1 (MGYG_03035), 2810481F14Rik, 4921509N21Rik, AI838772, AW493413, E430034L06Rik, F8M21.60, F8M21_60, MGC83708, MLZ-501, SCAN1, tdp1, TDP1, tyrosyl-DNA phosphodiesterase 1

Protein level used designations for TDP1

  • tyr-DNA phosphodiesterase 1
  • tyrosyl-DNA Phosphodiesterase (Tdp1)
  • protein expressed in male leptotene and zygotene spermatocytes 501
  • tyrosyl-DNA phodphodiesterase 1
  • tyrosyl-DNA phosphodiesterase 1
  • tyrosyl-DNA phosphodiesterase 1-like
  • Tyrosyl-DNA phosphodiesterase 1-like protein
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