(Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
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Latest Publications for our TDP1 products: "Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan." in: Molecular cancer therapeutics, Vol. 14, Issue 2, pp. 575-85, (2015) (PubMed).
: "PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage." in: Nucleic acids research, Vol. 42, Issue 7, pp. 4435-49, (2014) (PubMed).
: "Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes." in: Nature neuroscience, Vol. 17, Issue 6, pp. 813-21, (2014) (PubMed).
: "Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition." in: Biochemical pharmacology, Vol. 83, Issue 1, pp. 27-36, (2011) (PubMed).
: "In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation." in: DNA repair, Vol. 8, Issue 5, pp. 654-63, (2009) (PubMed).
: "Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK." in: The EMBO journal, Vol. 28, Issue 23, pp. 3667-80, (2009) (PubMed).
: "Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies." in: The Journal of biological chemistry, Vol. 284, Issue 13, pp. 8516-24, (2009) (PubMed).
: "TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo." in: The EMBO journal, Vol. 26, Issue 22, pp. 4720-31, (2007) (PubMed).
: "Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate ends." in: Nucleic acids research, Vol. 35, Issue 11, pp. 3797-809, (2007) (PubMed).
Synonyms and alternative names related to TDP1tyrosyl-DNA phosphodiesterase 1 (TDP1), tyrosyl-DNA Phosphodiesterase (Tdp1) (Tc00.1047053511191.10), tyrosyl-DNA phosphodiesterase 1 (Tdp1), tyrosyl-DNA phosphodiesterase 1 L homeolog (tdp1.L), tyrosyl-DNA phosphodiesterase 1 (tdp1), tyrosyl-DNA phosphodiesterase-like protein (TDP1), tyrosyl-DNA phosphodiesterase 1 (PTRG_11198), tyrosyl-DNA phosphodiesterase 1 (MCYG_02121), tyrosyl-DNA phosphodiesterase 1 (MGYG_03035), 2810481F14Rik, 4921509N21Rik, AI838772, AW493413, E430034L06Rik, F8M21.60, F8M21_60, MGC83708, MLZ-501, SCAN1, tdp1, TDP1, tyrosyl-DNA phosphodiesterase 1
Protein level used designations for TDP1
- tyr-DNA phosphodiesterase 1
- tyrosyl-DNA Phosphodiesterase (Tdp1)
- protein expressed in male leptotene and zygotene spermatocytes 501
- tyrosyl-DNA phodphodiesterase 1
- tyrosyl-DNA phosphodiesterase 1
- tyrosyl-DNA phosphodiesterase 1-like
- Tyrosyl-DNA phosphodiesterase 1-like protein
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