Protein Summary

This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene encodes the most probable candidate for synthesis of the type 1 Lewis antigens which are frequently found to be elevated in gastrointestinal and pancreatic cancers. The encoded protein is inactive with N-linked glycoproteins and functions in mucin glycosylation. Alternatively spliced transcript variants encoding the same protein have been observed for this gene.

Gene names and symbols associated with B3GALT5

• Beta-1,3-galactosyltransferase 5 (B3galt5) antibody
• beta-1,3-galactosyltransferase 5 (B3GALT5) antibody
• UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 (B3galt5) antibody

• 1190002B21Rik antibody
• AU045265 antibody
• b3Gal-T5 antibody
• b3Galt-V antibody
• B3GALT5 antibody
• Show all synonym aliases
• B3GalTx antibody
• B3T5 antibody
• beta-1,3-GalTase 5 antibody
• beta-3-Gx-T5 antibody
• beta3Gal-T5 antibody
• GLCT5 antibody

Protein level used designations for B3GALT5

beta-1,3-galactosyltransferase 5 , UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 , UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5 , beta-3-galactosyltransferase 5 , homolog of C. elegans Bt toxin resistance gene bre-5 , SSEA-3 synthase , UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5 , b3Gal-T5 , beta-1,3-GalTase 5 , beta-3-Gx-T5 , beta3Gal-T5 , beta3GalT5 , stage-specific embryonic antigen 3 synthase