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GALNT4 encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. Additionally we are shipping UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 4 (GalNAc-T4) Antibodies (40) and many more products for this protein.
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GALNT4 Expression Is Directly Regulated by miR (show MLXIP Proteins)-9.
Intronic SNP in POC1B (show POC1B Proteins)/GALNT4 locus (rs11105306) was associated with NT-proBNP levels in patients with acute coronary syndrome (ACS (show PLA2G15 Proteins)). The POC1B (show POC1B Proteins)/GALNT4 SNP was not associated with higher risk of cardiovascular death.
GALNT14 (show GALNT14 Proteins) may contribute to ovarian carcinogenesis through aberrant glycosylation of MUC13 (show MUC13 Proteins).
GALNT4 identified as a risk gene for cardiovascular disease, whose effects may be on either platelet or endothelial function through modifications of PSGL1 (show SELPLG Proteins) or other important glycosylated proteins.
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. In vitro, the encoded protein can complement other GalNAc-Ts in the complete O-glycosylation of the mucin-1 tandem repeat and can O-glycosylate the P-selectin glycoprotein ligand-1 molecule. The coding region of this gene is contained within a single exon. Fusion transcripts, which combine part of this gene with the 5' exons of the neighboring POC1B (POC1 centriolar protein homolog B) gene, also exist.
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4
, polypeptide GalNAc transferase 4
, polypeptide N-acetylgalactosaminyltransferase 4
, pp-GaNTase 4
, protein-UDP acetylgalactosaminyltransferase 4
, polypeptide GalNAc transferase-T4