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URI1 encodes member of the prefoldin family of molecular chaperones. Additionally we are shipping URI1, Prefoldin-Like Chaperone Antibodies (67) and many more products for this protein.
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Collectively, these findings indicate that RMP (show ABCA4 Proteins) promotes Epithelial-mesenchymal transition and hepatocellular carcinoma metastasis through NF-kappaB (show NFKB1 Proteins)/CSN2 (show CSN2 Proteins)/Snail (show SNAI1 Proteins) pathway. These results suggest that RMP (show ABCA4 Proteins) and p65 (show GORASP1 Proteins) may serve as potential candidates of the targets in the treatment of metastatic hepatocellular carcinoma.
These findings suggest that URI1 has properties of a 'non-oncogene (show RAB1A Proteins)' that supports the oncogenic phenotype of those cancer cells that have evolved a dependency on this molecular chaperone (show HSP90AA1 Proteins) system for survival
This work uncovers that URI-regulated OGT (show OGT Proteins) confers c-MYC (show MYC Proteins)-dependent survival functions in response to glucose fluctuations.
Amplification of 19q12 CCNE1 (show CCNE1 Proteins)/URI was found in 10.4% (28/270) and was significantly associated with type II endometrial cancer (EC) high grade, advanced FIGO stage, and aberrant tumor supressor p53 (show TP53 Proteins) expression.
that KAP1 phosphorylation is decreased following recruitment of PP2A by URI.
RMP (show ABCA4 Proteins) status in tumors may be a useful marker in estimating prognosis in patients with hepatocellular carcinoma and in assisting in the selection of patients who are likely to benefit from adjuvant TACE (show ADAM17 Proteins) to prevent relapse.
High URI1 expression is associated with epithelial ovarian cancer.
Results show that URI expression is essential for hepatocarcinogenesis and associated with poor survival.
URI may have an important role in the development of multiple myeloma and chemotherapeutic resistance through activation of the IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins) pathway.
Higher level of URI/RMP expression in high-grade endometrioid adenocarcinomas compared to tissues of adjacent endometrium or gland suggests a diagnostic and possibly, a prognostic value of URI/RMP in endometrioid adenocarcinoma.
This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22.
RNA polymerase II subunit 5-mediating protein
, RPB5-mediating protein
, protein phosphatase 1 regulatory subunit 19
, protein phosphatase 1, regulatory subunit 19
, unconventional prefoldin RPB5 interactor 1