Ubiquitin Fusion Degradation Protein 1 Homolog Proteins (UFD1L)

The protein encoded by UFD1L forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. Additionally we are shipping Ubiquitin Fusion Degradation Protein 1 Homolog Antibodies (106) and Ubiquitin Fusion Degradation Protein 1 Homolog Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UFD1L 7353 Q92890
UFD1L 22230 P70362
UFD1L 84478 Q9ES53
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Top Ubiquitin Fusion Degradation Protein 1 Homolog Proteins at antibodies-online.com

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,817.83
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Yeast Caenorhabditis elegans His tag   1 mg Log in to see 60 to 71 Days
$2,927.83
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Escherichia coli (E. coli) Human His tag 50 μg Log in to see 13 to 16 Days
$492.31
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Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$318.85
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UFD1L Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)
Rat (Rattus) ,

More Proteins for Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L) Interaction Partners

Human Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L) interaction partners

  1. We demonstrate that WT p97 (show EIF4G2 Proteins) can unfold proteins and that this activity is dependent on the p97 (show EIF4G2 Proteins) adaptor NPLOC4-UFD1L, ATP hydrolysis, and substrate ubiquitination, with branched chains providing maximal stimulation.

  2. The study revealed a regulatory role of the p97 (show EIF4G2 Proteins)-Npl4-Ufd1 complex in regulating a partial degradation of the NF-kappaB (show NFKB1 Proteins) subunit p100 (show CUX1 Proteins).

  3. p97-Ufd1-Npl4 is an integral part of G2/M checkpoint signaling and thereby suppresses chromosome instability.

  4. Data indicate that the p97-UFD1L-NPL4 protein complex specifically associates with ubiquitinated IkappaBalpha via the interactions between p97 and the SCF(beta-TRCP) ubiquitin ligase.

  5. This study demonistrated that UFD1L may participate in the core cognitive deficits observed in schizophrenia.

  6. In coordination with the P97 (show EIF4G2 Proteins)-UFD1-NPL4 complex (P97 (show EIF4G2 Proteins)(UFD1/NPL4)), NUB1L promotes transfer of NEDD8 (show NEDD8 Proteins) to proteasome for degradation.

  7. increased corpus callosum volume in children with 22q11DS is associated with UFD1L polymorphism.

  8. Data indicate that Npl4-Ufd1 heterodimer is required for VCP (show vcp Proteins)-FAF1 (show FAF1 Proteins) interaction.

  9. Data establish Cdc48/p97 (show vcp Proteins)-Ufd1-Npl4 as a crucial negative regulator of Aurora B (show AURKB Proteins) early in mitosis of human somatic cells and suggest that the activity of Aurora B (show AURKB Proteins) on chromosomes needs to be restrained to ensure faithful chromosome segregation.

  10. Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control

Mouse (Murine) Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L) interaction partners

  1. The study revealed a regulatory role of the p97 (show EIF4G2 Proteins)-Npl4-Ufd1 complex in regulating a partial degradation of the NF-kappaB (show NFKB1 Proteins) subunit p100 (show PATL2 Proteins).

  2. the p97-Ufd1-Npl4 complex couples ubiquitinated IP(3) receptors to proteasomal degradation and, thus, plays a key role in IP(3) receptor processing

  3. structural analysis of the p97 (show EIF4G2 Proteins)-Npl4-Ufd1 interface

Caenorhabditis elegans (C. elegans) Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L) interaction partners

  1. These findings identified a role for CDC-48(UFD-1/NPL-4) in DNA replication, which is important for cell cycle progression and genome stability.

Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L) Protein Profile

Protein Summary

The protein encoded by this gene forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18.

Gene names and symbols associated with UFD1L

  • ubiquitin recognition factor in ER associated degradation 1 (UFD1)
  • ubiquitin recognition factor in ER-associated degradation 1 (Ufd1)
  • ubiquitin recognition factor in ER associated degradation 1 (Ufd1)
  • ubiquitin fusion degradation 1 like (yeast) (UFD1L)
  • ubiquitin recognition factor in ER associated degradation 1 S homeolog (ufd1.S)
  • ubiquitin recognition factor in ER associated degradation 1 (ufd1l)
  • ubiquitin recognition factor in ER associated degradation 1 (ufd1)
  • ubiquitin fusion degradation protein 1 homolog (EHI_125920)
  • ubiquitin fusion degradation protein 1 homolog (LOC100166745)
  • ubiquitin fusion degradation protein 1 homolog (LOC100635687)
  • ubiquitin fusion degradation protein 1 homolog (LOC100648660)
  • Ubiquitin Fusion Degradation (yeast UFD homolog) (ufd-1)
  • ufd1 protein
  • Ufd1l protein
  • wu:fc55f04 protein
  • zgc:92341 protein

Protein level used designations for UFD1L

UB fusion protein 1 , ubiquitin fusion degradation protein 1 homolog , ubiquitin fusion degradation 1-like protein , fc55f04 , ubiquitin fusion degradation 1-like , ubiquitin fusion degradation 1 like (yeast) , ubiquitin fusion degradation 1 like

GENE ID SPECIES
7353 Homo sapiens
22230 Mus musculus
84478 Rattus norvegicus
374186 Gallus gallus
399034 Xenopus laevis
436724 Danio rerio
448516 Xenopus (Silurana) tropicalis
458650 Pan troglodytes
507124 Bos taurus
711716 Macaca mulatta
6219427 Entamoeba histolytica HM-1:IMSS
100166745 Acyrthosiphon pisum
100409073 Callithrix jacchus
100451821 Pongo abelii
100582577 Nomascus leucogenys
100635687 Amphimedon queenslandica
100648660 Bombus terrestris
100153062 Sus scrofa
608300 Canis lupus familiaris
3565860 Caenorhabditis elegans
100728094 Cavia porcellus
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