anti-Ubiquitin Protein Ligase E3 Component N-Recognin 4 (UBR4) Antibodies

The protein encoded by UBR4 is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. Additionally we are shipping UBR4 Kits (8) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
UBR4 23352 Q5T4S7
UBR4 69116 A2AN08
UBR4 313658 Q2TL32
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Top anti-UBR4 Antibodies at antibodies-online.com

Showing 10 out of 37 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Goat Un-conjugated ELISA, IHC   100 μg 6 to 7 Days
$429.87
Details
Human Goat Un-conjugated ELISA Immunohistochemistry (5μg/ml) staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 0.1 mg 2 to 3 Days
$550.00
Details
Bat Goat Un-conjugated ELISA, IHC, IHC (p) Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-UBR4 antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg 11 to 14 Days
$639.83
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μL 13 to 16 Days
$270.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of HeLa cells, using UBR4 antibody (ABIN6293214) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s. 50 μL 11 to 13 Days
$305.01
Details
Human Mouse Un-conjugated IF, ELISA, WB Immunofluorescence of monoclonal antibody to RBAF600 on HeLa cell. [antibody concentration 10 ug/ml] Detection limit for recombinant GST tagged RBAF600 is approximately 0.1ng/ml as a capture antibody. 100 μg 11 to 12 Days
$440.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (36.78 KDa) . 50 μL 11 to 12 Days
$305.71
Details
Human Goat Un-conjugated ELISA, IHC IHC testing of FFPE human spleen with UBR4 antibody at 5ug/ml. HIER: steamed with pH6 citrate buffer, AP-staining. 100 μg 2 to 3 Days
$452.38
Details
Human Goat Alkaline Phosphatase (AP) ELISA   100 μL 16 Days
$760.57
Details
Human Goat Biotin ELISA   100 μL 16 Days
$760.57
Details

Top referenced anti-UBR4 Antibodies

  1. Human Polyclonal UBR4 Primary Antibody for ICC, IF - ABIN440546 : Corteggio, Di Geronimo, Roperto, Roperto, Borzacchiello: Bovine papillomavirus E7 oncoprotein binds to p600 in naturally occurring equine sarcoids. in The Journal of general virology 2011 (PubMed)

  2. Human Polyclonal UBR4 Primary Antibody for IHC, IHC (p) - ABIN4364020 : Ling, Beaulé, Chiang, Tian, Figeys, Cheng: Time-of-day- and light-dependent expression of ubiquitin protein ligase E3 component N-recognin 4 (UBR4) in the suprachiasmatic nucleus circadian clock. in PLoS ONE 2014 (PubMed)

  3. Human Polyclonal UBR4 Primary Antibody for ELISA, IHC - ABIN4364019 : Lennerz, Fatho, Gentilini, Frye, Lifke, Ferel, Wölfel, Huber, Wölfel: The response of autologous T cells to a human melanoma is dominated by mutated neoantigens. in Proceedings of the National Academy of Sciences of the United States of America 2005 (PubMed)

More Antibodies against UBR4 Interaction Partners

Human Ubiquitin Protein Ligase E3 Component N-Recognin 4 (UBR4) interaction partners

  1. The endosomal recruitment of UBR4 is essential for the biogenesis of early endosomes and endosome-related processes.

  2. Pathogenic mutation in UBR4 gene is associated with Episodic Ataxia.

  3. Ubiquitin ligase Ubr4 is a key component of the podocin interactome purified from podocytes. Ubiquitylation of one podocin site, K301, do not only target podocin for proteasomal degradation, but may also affect stability and disassembly of the multimeric complex.

  4. Results showed KCMF1 C-terminus binds directly to RAD6, whereas N-terminal domains interact with UBR4 and point mutations found in X-linked intellectual disability (XLID) patients specifically lose the interaction with KCMF1 and UBR4.

  5. This review summarizes the central nervous system functions of p600 and proposes new perspectives on its biological complexity in neuronal physiology and neurological diseases.

  6. Although UBR4 is not an ion channel gene, the potential for disrupted Ca(2+) control within neuronal cells highlights its potential for a role in this form of episodic ataxia.

  7. Dengue virus co-opts UBR4 to degrade STAT2 and antagonize type I interferon signaling.

  8. Human papillomavirus E7 oncoprotein associates with p600; interaction strongly contributes to cellular transformation independent of ability of E7 to bind pRB.

  9. Results identify and characterize p600, a unique 600-kDa retinoblastoma protein- and calmodulin-binding protein.

Mouse (Murine) Ubiquitin Protein Ligase E3 Component N-Recognin 4 (UBR4) interaction partners

  1. UBR4-deficient mouse embryos suffer from multiple abnormalities in neurogenesis and other developmental processes. Histological and cytological examinations suggest that the cells in mutant embryos fail to maintain their morphology and adhesion, leading to failure to communicate with each other and advance into more differentiated stages.

  2. Ubiquitin ligase Ubr4 is a key component of the podocin interactome purified from cultured podocytes and native glomeruli. Ubiquitylomic analysis of mouse glomeruli revealed that podocin is ubiquitylated at two lysine residues. Ubiquitylation of one podocin site, K301, do not only target podocin for proteasomal degradation, but may also affect stability and disassembly of the multimeric complex.

  3. This study is the first to identify a novel E3 ubiquitin ligase component, UBR4, in the murine SCN and to implicate the N-end rule degradation pathway as a potential player in regulating core clock mechanisms and photic entrainment.

  4. UBR4-deficient mice die during embryogenesis and exhibit pleiotropic abnormalities, including impaired vascular development in the yolk sac.

  5. Found murine p600 (formally called RBAF600) copurified with the E7 oncoprotein in C127 cells. This interaction was found to correlate with the ability of E7 to increase transformation.

  6. This study identified protein 600 (p600) as a novel microtubule-associated protein (MAP) developmentally regulated in neurons. p600 exhibits the unique feature to interact with the endoplasmic reticulum (ER).

  7. Member of UBR box protein family, termed Ubr4. Binds to destabilizing N-terminal residues of N-end rule substrates. Participates in degradation of N-end rule substrates.

UBR4 Antigen Profile

Protein Summary

The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein.

Gene names and symbols associated with UBR4

  • ubiquitin protein ligase E3 component n-recognin 4 (UBR4) antibody
  • ubiquitin protein ligase E3 component n-recognin 4 (Ubr4) antibody
  • E3 ubiquitin-protein ligase UBR4 (LOC100511934) antibody
  • 1810009A16Rik antibody
  • A930005E13Rik antibody
  • D930005K06Rik antibody
  • Gm1032 antibody
  • Gm1666 antibody
  • mKIAA0462 antibody
  • N28143 antibody
  • p600 antibody
  • Rbaf600 antibody
  • Zubr1 antibody

Protein level used designations for UBR4

retinoblastoma-associated factor 600 , zinc finger, UBR1 type 1 , E3 ubiquitin-protein ligase UBR4 , N-recognin-4 , retinoblastoma-associated factor 600-like protein , retinoblastoma-associated factor of 600 kDa , zinc finger UBR1-type protein 1 , ZUBR1

GENE ID SPECIES
456576 Pan troglodytes
23352 Homo sapiens
478211 Canis lupus familiaris
69116 Mus musculus
313658 Rattus norvegicus
100511934 Sus scrofa
419469 Gallus gallus
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