Ubiquitin Specific Peptidase 14 (USP14) ELISA Kits

USP14 encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. Additionally we are shipping USP14 Antibodies (84) and USP14 Proteins (14) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
USP14 9097 P54578
Anti-Mouse USP14 USP14 59025 Q9JMA1
Anti-Rat USP14 USP14 291796  
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Top USP14 ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.108 ng/mL 0.31 ng/mL - 20 ng/mL 96 Tests Log in to see 13 to 16 Days
$736.84
Details

More ELISA Kits for USP14 Interaction Partners

Human Ubiquitin Specific Peptidase 14 (USP14) interaction partners

  1. USP14 acts as a negative regulator in antiviral response through deubiquitinating K63-linked RIG-I

  2. High USP14 expression is associated with Osteoarthritis.

  3. The proteasome-associated deubiquitinating enzyme Usp14/UBP6 contains an N-terminal ubiquitin-like UBL domain and is an important regulator of proteasomal activity. Usp14 by itself represses multiple proteasomal activities but, upon binding a ubiquitin chain, Usp14 promotes ubiquitin-conjugate degradation. Usp14's UBL domain alone mimics this activation of proteasomes by ubiquitin chains.

  4. By displacing USP14, TRIM11 changes proteasome composition and suppresses both catalytic and non-catalytic effects of USP14

  5. Usp14 and Ube3c cycle together on and off proteasomes, and the presence of ubiquitinated substrates promotes their association. This mechanism enables proteasome activity to adapt to the supply of substrates.

  6. our results demonstrated that vimentin in human GC tissues and cell lines was upregulated due to its de-ubiquitination after interactions with USP14 and miR-320a, which could promote the aggressiveness of GC cells.

  7. Study detected elevated USP14 expression at both mRNA and protein levels, and was significantly associated with distant metastasis.

  8. These findings suggested that USP14 induces NF-kappaB activity and ERK1/2 phosphorylation triggered by microbial infection.

  9. Ubiquitin-specific protease 14 regulates cell proliferation and apoptosis in oral squamous cell carcinoma

  10. our report demonstrates significant value in targeting USP14/UCHL5 with VLX1570 in drug-resistant Waldenstrom macroglobulinemia (WM) and carries a high potential for clinical translation

  11. USP14 promotes prostate cancer progression.

  12. without a ubiquitinated substrate present, Usp14 suppresses multiple proteasomal activities, especially basal ATP consumption and degradation of non-ubiquitinated proteins. These allosteric effects thus reduce ATP hydrolysis by inactive proteasomes and nonspecific proteolysis and enhance proteasomal specificity for ubiquitinated proteins.

  13. USP14 regulates autophagy by negatively controlling K63 ubiquitination of Beclin 1

  14. USP14 plays an important role in the progression and metastasis of esophageal squamous cell carcinoma.

  15. USP14 participates in CAM-DR of MM through acting as a bridge between Bcl-xl apoptotic pathway and Wnt-signaling pathways and may be represented as a good candidate for pursuing clinical trials in MM.

  16. Results show that USP14 mRNA is overexpressed in hepatocellular carcinoma (HCC) tissues and inversely correlates with miR-4782-3p level which binds to USP14 3'UTR to regulate its expression.

  17. Results found USP14 amplification and overexpression in many different cancers. Its overexpression in low-expression cell lines promoted cell proliferation and migration, whereas its downregulation suppressed tumor cell proliferation, increased apoptosis rate, and decreased cell migration and invasion suggesting an oncogenic role in various types of cancer.

  18. Increased USP14 expression in patients with breast cancer was associated with a poorer prognosis.

  19. Akt-mediated phosphorylation of USP14 at Ser432, which normally blocks its catalytic site in the inactive conformation, activates its deubiquitinating activity in vitro and in cells.

  20. our findings suggested that USP14 is involved in the progression of hepatocellular carcinoma(HCC) and may be a useful therapeutic target in HCC

Mouse (Murine) Ubiquitin Specific Peptidase 14 (USP14) interaction partners

  1. High USP14 expression is associated with Osteoarthritis.

  2. the data indicate that functional Usp14 enhances direct Antigen presentation, preferentially of defective ribosomal product-derived peptides, suggesting that the processing of defective ribosomal product-derived peptides is in some ways different from other forms of Antigen.

  3. The homeostasis of Ubiquitin in USP14-/-mouse embryonic fibroblasts was markedly perturbed because of facilitated clearance of Ubiquitin.

  4. Usp14 and Ube3c cycle together on and off proteasomes, and the presence of ubiquitinated substrates promotes their association. This mechanism enables proteasome activity to adapt to the supply of substrates.

  5. analysis of the molecular mechanisms through which CBP stability is regulated by FBXL19 and USP14, which results in the modulation of chromatin remodeling and the expression of cytokine-encoding genes

  6. These findings suggested that USP14 induces NF-kappaB activity and ERK1/2 phosphorylation triggered by microbial infection.

  7. without a ubiquitinated substrate present, Usp14 suppresses multiple proteasomal activities, especially basal ATP consumption and degradation of non-ubiquitinated proteins. These allosteric effects thus reduce ATP hydrolysis by inactive proteasomes and nonspecific proteolysis and enhance proteasomal specificity for ubiquitinated proteins.

  8. USP14's catalytic activity is required for nervous system structure and function and has an ongoing role in NMJ synaptic transmission. USP14 regulation of the ubiquitination status of protein kinases, coordinates NMJ intracellular signaling pathways.

  9. Overexpression of the Usp14 reduces cellular aggregates in mutant Htt-expressing cells mainly via the ubiquitin proteasome system.

  10. USP14 modulates hippocampal short-term plasticity and vesicle number independent of its deubiquitinating activity.

  11. Differences in genetic background were shown to affect ubiquitin expression and dramatically alter the phenotypes caused by USP14 deficiency.

  12. Data indicate that increased levels of phosphorylated tau correlated with the onset of axonal varicosities in the ubiquitin-specific protease 14 (Usp14)-deficient mice.

  13. miR-124 promotes neuronal survival under ischemic conditions via Usp14-dependent REST degradation.

  14. overexpression of HA-USP14 increased TNFalpha

  15. Oxidative stress increasd USP14 expression, and beta-carotene dose-dependently inhibited increased expression in mouse skeletal muscle myotubes.

  16. ubiquitinated loosely folded proteins, after becoming bound to the 26 S, interact with Ubp6/Usp14 or Uch37 to activate ATP hydrolysis and enhance their own destruction

  17. USP14 has a role in regulating synaptic activity in mammals

  18. Usp14 functions to maintain the cellular levels of monomeric ubiquitin in mammalian cells, and that alterations in the levels of ubiquitin may contribute to neurological disease

  19. Results suggest that Uch-L1 and Usp14 may differentially affect the ubiquitin proteasome system and synaptic activity by regulating different pools of ubiquitin in the cell.

  20. A mutated axJ gene locus, encoding the ubiquitin-specific protease 14 (Usp14), negatively influences GABAA receptor turnover.

USP14 Antigen Profile

Antigen Summary

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with USP14

  • ubiquitin specific peptidase 14 (USP14) antibody
  • peptidase C19 family protein (usp14) antibody
  • ubiquitin specific peptidase 14 (Usp14) antibody
  • ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) (usp14) antibody
  • ubiquitin specific protease 14 (Bm1_28765) antibody
  • ubiquitin specific peptidase 14 S homeolog (usp14.S) antibody
  • ubiquitin specific peptidase 14 (usp14) antibody
  • universal stress protein (RR_RS06480) antibody
  • Ubiquitin carboxyl-terminal hydrolase 14 (usp-14) antibody
  • 2610005K12Rik antibody
  • 2610037B11Rik antibody
  • AW107924 antibody
  • ax antibody
  • C78769 antibody
  • DDBDRAFT_0202821 antibody
  • DDBDRAFT_0237695 antibody
  • DDB_0202821 antibody
  • DDB_0237695 antibody
  • MGC69343 antibody
  • MGC81945 antibody
  • tgt antibody
  • USP14 antibody
  • wu:fk63d09 antibody
  • zgc:55949 antibody

Protein level used designations for USP14

deubiquitinating enzyme 14 , tRNA-guanine transglycosylase, 60-kD subunit , ubiquitin carboxyl-terminal hydrolase 14 , ubiquitin specific protease 14 (tRNA-guanine transglycosylase) , ubiquitin thioesterase 14 , ubiquitin thiolesterase 14 , ubiquitin-specific processing protease 14 , ubiquitin-specific-processing protease 14 , ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) , ubiquitin domain-containing protein , ataxia , dUB-type TGT for deubiquitinating enzyme , ubiquitin specific protease 14 , universal stress protein , queuine tRNA-ribosyltransferase , ubiquitin carboxyl-terminal hydrolase 14-like

GENE ID SPECIES
9097 Homo sapiens
100090009 Ornithorhynchus anatinus
8617881 Dictyostelium discoideum AX4
59025 Mus musculus
291796 Rattus norvegicus
335736 Danio rerio
455325 Pan troglodytes
505106 Bos taurus
6100653 Brugia malayi
421063 Gallus gallus
447733 Xenopus laevis
448110 Xenopus (Silurana) tropicalis
480182 Canis lupus familiaris
698087 Macaca mulatta
3130489 Haloarcula marismortui ATCC 43049
100009078 Oryctolagus cuniculus
100013535 Monodelphis domestica
100394297 Callithrix jacchus
100473541 Ailuropoda melanoleuca
100586916 Nomascus leucogenys
175105 Caenorhabditis elegans
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