anti-Ubiquitin Specific Peptidase 17-Like 2 (USP17L2) Antibodies

Human Ubiquitin Specific Peptidase 17-Like 2 (USP17L2) interaction partners

1. these data identify DUB3 and USP7 (show USP7 Antibodies) as factors that regulate DNA replication by controlling Geminin protein (show GMNN Antibodies) stability, and suggest that USP7 (show USP7 Antibodies) may be involved in Geminin (show GMNN Antibodies) dysregulation during breast cancer progression.

2. We provide evidence that DUB3 proteins regulate YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies) activity by controlling the stability of the E3 ligase ITCH, the LATS (show LATS1 Antibodies) kinases and the AMOT (show AMOT Antibodies) family proteins. As a novel Hippo pathway regulator, DUB3 has the potential to act a tumor suppressor by limiting YAP (show YAP1 Antibodies) activity.

3. In cigarette smoke extract-exposed airway epithelial cells and macrophages, HDAC2 (show HDAC2 Antibodies) is excessively ubiquitinated and degraded in the proteasome attributed to low expression of USP17.

4. These data indicate that the Dub3 might be a valuable biomarker for the prediction of ovarian cancer prognosis and Dub3 inhibition might be a potential strategy for ovarian cancer treatment.

5. Dub3 counteracts H2AX E3 ligases RNF8 and RNF168. Moreover, Dub3 and H2AX interact and Dub3 deubiquitinates H2AX in vitro.

6. Recently, much progress has been made in understanding the physiological functions of cytokine-inducible DUBs such as DUB-1 (show USP36 Antibodies), DUB-2, and DUB-3/USP17, in regulation of cell proliferation and apoptosis in lymphocytes. [review]

7. As a major regulator of Cdc25A, Dub3 is an example of a transforming ubiquitin hydrolase that subverts a key component of the cell cycle machinery, promoting oncogenic transformation.

8. human DUB-3, like the murine DUB family members, is transiently induced in response to cytokines and can, when constitutively expressed, block growth factor-dependent proliferation.

9. Identifies DUB3 as being one of 30 genes with the most variable copy numbers in three human genomes.

Mouse (Murine) Ubiquitin Specific Peptidase 17-Like 2 (USP17L2) interaction partners

1. Using a reporter assay, we show that NCoA1 (show NCOA1 Antibodies) potentiates Esrrb (show ESRRB Antibodies)-mediated transcription of Dub3 and we present evidence of protein interaction between the SRC1 (show NCOA1 Antibodies) splice variant NCoA1 (show NCOA1 Antibodies) and Esrrb (show ESRRB Antibodies)

2. We show that Dub3 expression is strongly downregulated during neural conversion and precedes Cdc25A (show CDC25A Antibodies) destabilization, while forced Dub3 expression in ESCs (show NR2E3 Antibodies) becomes lethal upon differentiation