anti-Ubiquitin Specific Peptidase 17-Like 2 (USP17L2) Antibodies

Deubiquitinating enzyme that specifically removes conjugated ubiquitin from CDC25A, thereby playing a key role in cell cycle regulation. Additionally we are shipping USP17L2 Proteins (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
USP17L2 377630 Q6R6M4
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Top anti-USP17L2 Antibodies at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-USP17L2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human heart WB Suggested Anti-USP17L2  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: Human heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) . Dilution: 1:500~1000 Detection limit for recombinant GST tagged DUB3 is approximately 0.3ng/ml as a capture antibody. 100 μg Log in to see 8 to 11 Days
$461.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated WB Western Blot: Dub3 Antibody [NBP1-79745] - Human Heart lysate, concentration 0.2-1 ug/ml. 100 μL Log in to see 7 to 9 Days
$485.88
Details
Human Rabbit Un-conjugated WB   400 μL Log in to see 11 to 14 Days
$463.83
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged DUB3 is approximately 0.3ng/ml as a capture antibody. Western Blot detection against Immunogen (36.74 KDa) . 100 μg Log in to see 11 to 12 Days
$440.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (37.11 KDa) . 50 μL Log in to see 11 to 12 Days
$305.71
Details
Human Rabbit Un-conjugated FACS, WB   400 μL Log in to see 11 to 14 Days
$463.83
Details
Human Rabbit Un-conjugated WB   50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated WB   400 μL Log in to see 6 to 8 Days
$454.30
Details

More Antibodies against USP17L2 Interaction Partners

Human Ubiquitin Specific Peptidase 17-Like 2 (USP17L2) interaction partners

  1. these data identify DUB3 and USP7 (show USP7 Antibodies) as factors that regulate DNA replication by controlling Geminin protein (show GMNN Antibodies) stability, and suggest that USP7 (show USP7 Antibodies) may be involved in Geminin (show GMNN Antibodies) dysregulation during breast cancer progression.

  2. We provide evidence that DUB3 proteins regulate YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies) activity by controlling the stability of the E3 ligase ITCH, the LATS (show LATS1 Antibodies) kinases and the AMOT (show AMOT Antibodies) family proteins. As a novel Hippo pathway regulator, DUB3 has the potential to act a tumor suppressor by limiting YAP (show YAP1 Antibodies) activity.

  3. In cigarette smoke extract-exposed airway epithelial cells and macrophages, HDAC2 (show HDAC2 Antibodies) is excessively ubiquitinated and degraded in the proteasome attributed to low expression of USP17.

  4. These data indicate that the Dub3 might be a valuable biomarker for the prediction of ovarian cancer prognosis and Dub3 inhibition might be a potential strategy for ovarian cancer treatment.

  5. Dub3 counteracts H2AX E3 ligases RNF8 and RNF168. Moreover, Dub3 and H2AX interact and Dub3 deubiquitinates H2AX in vitro.

  6. Recently, much progress has been made in understanding the physiological functions of cytokine-inducible DUBs such as DUB-1 (show USP36 Antibodies), DUB-2, and DUB-3/USP17, in regulation of cell proliferation and apoptosis in lymphocytes. [review]

  7. As a major regulator of Cdc25A, Dub3 is an example of a transforming ubiquitin hydrolase that subverts a key component of the cell cycle machinery, promoting oncogenic transformation.

  8. human DUB-3, like the murine DUB family members, is transiently induced in response to cytokines and can, when constitutively expressed, block growth factor-dependent proliferation.

  9. Identifies DUB3 as being one of 30 genes with the most variable copy numbers in three human genomes.

Mouse (Murine) Ubiquitin Specific Peptidase 17-Like 2 (USP17L2) interaction partners

  1. Using a reporter assay, we show that NCoA1 (show NCOA1 Antibodies) potentiates Esrrb (show ESRRB Antibodies)-mediated transcription of Dub3 and we present evidence of protein interaction between the SRC1 (show NCOA1 Antibodies) splice variant NCoA1 (show NCOA1 Antibodies) and Esrrb (show ESRRB Antibodies)

  2. We show that Dub3 expression is strongly downregulated during neural conversion and precedes Cdc25A (show CDC25A Antibodies) destabilization, while forced Dub3 expression in ESCs (show NR2E3 Antibodies) becomes lethal upon differentiation

USP17L2 Antigen Profile

Protein Summary

Deubiquitinating enzyme that specifically removes conjugated ubiquitin from CDC25A, thereby playing a key role in cell cycle regulation. Deubiquitination of CDC25A prevents its degradation by the proteasome during the G1/S and G2/M phases of the cell cycle and is required for cell-cycle progression. Has transforming capabilities on cell lines. May also function in cell apoptosis.

Gene names and symbols associated with USP17L2

  • ubiquitin specific peptidase 17-like family member 2 (USP17L2) antibody
  • ubiquitin carboxyl-terminal hydrolase 17 (LOC695235) antibody
  • DUB-3 antibody
  • DUB3 antibody
  • USP17 antibody

Protein level used designations for USP17L2

deubiquitinating enzyme 17-like protein 2 , deubiquitinating enzyme 3 , deubiquitinating protein 3 , ubiquitin carboxyl-terminal hydrolase 17 , ubiquitin carboxyl-terminal hydrolase 17-like protein 2 , ubiquitin specific peptidase 17-like 2 , ubiquitin thioesterase 17-like protein 2 , ubiquitin thiolesterase 17-like protein 2 , ubiquitin-specific-processing protease 17-like protein 2

GENE ID SPECIES
377630 Homo sapiens
695235 Macaca mulatta
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