Protein Summary

The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15.

Gene names and symbols associated with USP18

• ubiquitin specific peptidase 18 (USP18) antibody
• ubiquitin specific peptidase 18 (Usp18) antibody

• 1110058H21Rik antibody
• AW047653 antibody
• bubp43 antibody
• ISG43 antibody
• UBP antibody
• Show all synonym aliases
• Ubp15 antibody
• UBP43 antibody
• USP18 antibody
• USP41 antibody

Protein level used designations for USP18

43 kDa ISG15-specific protease , ISG15-specific-processing protease , hUBP43 , ubiquitin specific protease 18 , ubl carboxyl-terminal hydrolase 18 , ubl thioesterase 18 , ubl thiolesterase 18 , ubiquitin specific peptidase 18 , ubiquitin specific protease 15 , interferon-stimulated gene 43 , ubiquitin-specific protease 18 , ubiquitin specific peptidase 41