Ubiquitin Specific Peptidase 18 (USP18) ELISA Kits

The protein encoded by USP18 belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. Additionally we are shipping USP18 Antibodies (33) and USP18 Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
USP18 11274 Q9UMW8
Anti-Rat USP18 USP18 312688  
Anti-Mouse USP18 USP18 24110 Q9WTV6
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Top USP18 ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.094 ng/mL 0.15 ng/mL - 10 ng/mL A typical standard curve 96 Tests Log in to see 13 to 16 Days
$641.23
Details

More ELISA Kits for USP18 Interaction Partners

Human Ubiquitin Specific Peptidase 18 (USP18) interaction partners

  1. The authors have found that USP18 has the novel ability to inhibit the antiviral function of p21 in differentiated THP-1 cells. USP18 enhanced reverse transcription of HIV-1 by downregulating p21 expression and upregulating intracellular dNTP levels.

  2. The structures of ubiquitin-specific protease 18 (USP18) and a USP18-Interferon-stimulated 15-KDa protein (ISG15) complex indicate the molecular basis of the specificity of the protease and its interaction with the type I interferon receptor [Review].

  3. These results demonstrate that virus-induced IFN-lambda4 potently blocks IFN-alpha signalling by inducing high protein levels of ISG15 and USP18. Moreover, the data clearly demonstrate that DAA therapy restores IFN-alpha responsiveness in HCV-infected cells.

  4. The role of USP18 in breast cancer provides a novel insight into the clinical application of the USP18/AKT/Skp2 pathway.

  5. High expression levels of USP18 in the muscles of dermatomyositis patients.

  6. study preliminary elucidated the role of USP18 in hepatitis B virus replication and explored the potential key genes in USP18-mediated signaling pathway

  7. this study identified PTEN as a previously unrecognized substrate of the ISGylation post-translational modification pathway. The deconjugase USP18 serves as a novel regulator of PTEN stability. This indicates inhibition of ISGylation is therapeutically relevant in cancers.

  8. associates with and deubiquitinates TAK1 to protect against hepatic steatosis, insulin resistance, and the inflammatory response

  9. that Ubiquitin-specific peptidase 18 directly bind to BCL2L1 and positively regulated its expression in hepatocellular carcinoma cells

  10. These findings add USP18 deficiency to the list of genetic disorders collectively termed type I interferonopathies

  11. We show that IRF-7 siRNA knockdown enhanced LPS-induced IL-10 production in human monocyte-derived macrophages, and USP-18 overexpression attenuated LPS-induced production of IL-10 in RAW264.7 cells. Quantitative PCR confirmed upregulation of USP18, USP41, IL10, and IRF7. An independent cohort confirmed LPS induction of USP41 and IL10 genes

  12. results indicated that USP18 modulates the anti-HBV activity of IFN-F via activation of the JAK/STAT signaling pathway in Hepg2.2.15 cells.

  13. USP18's ISG15 specificity is mediated by a small interaction interface.

  14. STAT2 recruits USP18 to the type I IFN receptor subunit IFNAR2 via its constitutive membrane-distal STAT2-binding site.

  15. findings show that multiple inflammatory stimuli can modulate interferon stimulated gene expression and thus inhibit hepatocyte interferon signaling via USP18 induction

  16. USP18 negatively regulates NF-kappaB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms.

  17. Data suggest that USP18 (Ubiquitin-like specific protease 18) sensitive cellular functions include activity of the peptide transporters PEPT1 and PEPT2.

  18. Dimerization of IFNAR1 and IFNAR2 and the limiting role of IFNAR1 binding affinity in complex assembly is modulated by USP18.

  19. increased expression in the HIV+/HCV+ female patients group compared with HIV-/HCV+ and HIV+/HCV- groups

  20. USP18 expression levels induced by IFNbeta did not differ amongst multiple sclerosis patients carrying different rs2542109 genotypes

Mouse (Murine) Ubiquitin Specific Peptidase 18 (USP18) interaction partners

  1. Usp18 protects the cells from oxidative stress-induced apoptosis which may be through the regulation of p53 and caspase 3.

  2. associates with and deubiquitinates TAK1 to protect against hepatic steatosis, insulin resistance, and the inflammatory response

  3. this study identifies the osteopenia phenotype of mice lacking Usp18, which is known as a negative regulator of type I IFN signaling

  4. USP18 has a protective role in pathological cardiac remodeling in mouse.

  5. USP18's ISG15 specificity is mediated by a small interaction interface.

  6. findings show that multiple inflammatory stimuli can modulate interferon stimulated gene expression and thus inhibit hepatocyte interferon signaling via USP18 induction

  7. Increased ISGylation was accompanied by enhanced viral resistance without causing detrimental side effects suggesting that USP18 protease inhibition might be a suitable antiviral strategy

  8. USP18 null mice develop leiomyosarcoma recapitulating key features of clinical leiomyosarcomas and patients with reduced-USP18 tumor levels have an unfavorable outcome.

  9. USP18 lack in microglia causes destructive interferonopathy of the mouse brain.

  10. results suggest that increasing ISGylation by specific inhibition of USP18 protease activity could constitute a promising antiviral strategy with only a minimal risk of severe adverse effects

  11. USP18 is crucial for IFN-gamma-mediated inhibition of B16 melanoma tumorigenesis and antitumor immunity.

  12. Usp18-driven enforced viral replication in dendritic cells can break immunological tolerance and critically influences induction of autoimmunity.

  13. Hypersensitivity of Usp18 knockout in mammary epithelial cells to IFN-gamma enhances Cxcl10 expression and protects against mammary tumour progression.

  14. USP18 inhibits NF-kappaB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex.

  15. Usp18 upregulation was associated with Wilms Tumor.

  16. although UBP43 depletion can cause hypersensitivity to interferon-alpha/beta-mediated apoptosis in a broad range of cell types, the downstream pathway may vary depending on the cell type.

  17. Usp18 modulates conventional CD11b+ dendritic cell development via its inhibitory effect on type I IFN signaling.

  18. These results show the impact of USP18 in the development of Salmonella-induced typhlitis.

  19. UBP43 (USP18) specifically removes ISG15 from conjugated proteins

  20. UBP43 plays a critical role in maintaining the homeostatic balance of ISG15-conjugated protein, and that regulation of cellular levels of ISG15 protein modification is essential for brain cell function.

Pig (Porcine) Ubiquitin Specific Peptidase 18 (USP18) interaction partners

  1. These data highlight USP18 as a host restriction factor during innate immune response to porcine respiratory and reproductive syndrome virus.

  2. USP18 is a potential target gene that promotes reduced replication of PRRSV.

  3. Results report identification and cloning of the ISG15 and ISG43 genes in pig.

USP18 Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15.

Gene names and symbols associated with USP18

  • ubiquitin specific peptidase 18 (USP18) antibody
  • ubiquitin specific peptidase 18 (Usp18) antibody
  • 1110058H21Rik antibody
  • AW047653 antibody
  • bubp43 antibody
  • ISG43 antibody
  • UBP antibody
  • Ubp15 antibody
  • UBP43 antibody
  • USP18 antibody
  • USP41 antibody

Protein level used designations for USP18

43 kDa ISG15-specific protease , ISG15-specific-processing protease , hUBP43 , ubiquitin specific protease 18 , ubl carboxyl-terminal hydrolase 18 , ubl thioesterase 18 , ubl thiolesterase 18 , ubiquitin specific peptidase 18 , ubiquitin specific protease 15 , interferon-stimulated gene 43 , ubiquitin-specific protease 18 , ubiquitin specific peptidase 41

GENE ID SPECIES
11274 Homo sapiens
312688 Rattus norvegicus
486763 Canis lupus familiaris
515202 Bos taurus
24110 Mus musculus
396777 Sus scrofa
418167 Gallus gallus
742929 Pan troglodytes
100054488 Equus caballus
100171781 Pongo abelii
100583021 Nomascus leucogenys
100729301 Cavia porcellus
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