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The protein encoded by USP18 belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. Additionally we are shipping USP18 Antibodies (37) and USP18 Proteins (4) and many more products for this protein.
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The role of USP18 in breast cancer provides a novel insight into the clinical application of the USP18/AKT/Skp2 pathway.
High expression levels of USP18 in the muscles of dermatomyositis patients.
study preliminary elucidated the role of USP18 in hepatitis B virus replication and explored the potential key genes in USP18-mediated signaling pathway
this study identified PTEN as a previously unrecognized substrate of the ISGylation post-translational modification pathway. The deconjugase USP18 serves as a novel regulator of PTEN stability. This indicates inhibition of ISGylation is therapeutically relevant in cancers.
associates with and deubiquitinates TAK1 (show MAP3K7 ELISA Kits) to protect against hepatic steatosis, insulin (show INS ELISA Kits) resistance, and the inflammatory response
that Ubiquitin-specific peptidase 18 directly bind to BCL2L1 (show BCL2L1 ELISA Kits) and positively regulated its expression in hepatocellular carcinoma cells
These findings add USP18 deficiency to the list of genetic disorders collectively termed type I interferonopathies
We show that IRF-7 (show IRF7 ELISA Kits) siRNA knockdown enhanced LPS-induced IL-10 (show IL10 ELISA Kits) production in human monocyte-derived macrophages, and USP-18 overexpression attenuated LPS-induced production of IL-10 (show IL10 ELISA Kits) in RAW264.7 cells. Quantitative PCR confirmed upregulation of USP18, USP41, IL10 (show IL10 ELISA Kits), and IRF7 (show IRF7 ELISA Kits). An independent cohort confirmed LPS induction of USP41 and IL10 (show IL10 ELISA Kits) genes
results indicated that USP18 modulates the anti-HBV activity of IFN-F via activation of the JAK (show JAK3 ELISA Kits)/STAT (show STAT1 ELISA Kits) signaling pathway in Hepg2.2.15 cells.
USP18's ISG15 (show ISG15 ELISA Kits) specificity is mediated by a small interaction interface.
Usp18 protects the cells from oxidative stress-induced (show SQSTM1 ELISA Kits) apoptosis which may be through the regulation of p53 (show TP53 ELISA Kits) and caspase 3 (show CASP3 ELISA Kits).
associates with and deubiquitinates TAK1 (show NR2C2 ELISA Kits) to protect against hepatic steatosis, insulin (show INS ELISA Kits) resistance, and the inflammatory response
this study identifies the osteopenia phenotype of mice lacking Usp18, which is known as a negative regulator of type I IFN signaling
USP18 has a protective role in pathological cardiac remodeling in mouse.
findings show that multiple inflammatory stimuli can modulate interferon (show IFNA ELISA Kits) stimulated gene expression and thus inhibit hepatocyte interferon (show IFNA ELISA Kits) signaling via USP18 induction
Increased ISGylation was accompanied by enhanced viral resistance without causing detrimental side effects suggesting that USP18 protease inhibition might be a suitable antiviral strategy
USP18 null mice develop leiomyosarcoma recapitulating key features of clinical leiomyosarcomas and patients with reduced-USP18 tumor levels have an unfavorable outcome.
USP18 lack in microglia causes destructive interferonopathy of the mouse brain.
results suggest that increasing ISGylation by specific inhibition of USP18 protease activity could constitute a promising antiviral strategy with only a minimal risk of severe adverse effects
These data highlight USP18 as a host restriction factor during innate immune response to porcine respiratory and reproductive syndrome virus.
USP18 is a potential target gene that promotes reduced replication of PRRSV.
Results report identification and cloning of the ISG15 (show ISG15 ELISA Kits) and ISG43 genes in pig.
The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15.
43 kDa ISG15-specific protease
, ISG15-specific-processing protease
, ubiquitin specific protease 18
, ubl carboxyl-terminal hydrolase 18
, ubl thioesterase 18
, ubl thiolesterase 18
, ubiquitin specific peptidase 18
, ubiquitin specific protease 15
, interferon-stimulated gene 43
, ubiquitin-specific protease 18
, ubiquitin specific peptidase 41