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USP30, a member of the ubiquitin-specific protease family (see USP1, MIM 603478), is a novel mitochondrial deubiquitinating (DUB) enzyme (Nakamura and Hirose, 2008 [PubMed 18287522]).[supplied by OMIM, Dec 2008].. Additionally we are shipping Usp30 Proteins (7) and many more products for this protein.
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Human Polyclonal Usp30 Primary Antibody for IHC, IHC (p) - ABIN4364579
Bingol, Tea, Phu, Reichelt, Bakalarski, Song, Foreman, Kirkpatrick, Sheng: The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. in Nature 2014
the role of USP30 in the dynamic networks of mitochondrial quality control and its physiological implications.
Here the authors report crystal structures of human USP30 bound to monoubiquitin and Lys6-linked diubiquitin, which explain how USP30 achieves Lys6-linkage preference through unique ubiquitin binding interfaces.
show that USP30 delays mitophagy by delaying PARK2 recruitment to the mitochondria during mitophagy
These results provide the first evidence for a fundamental role of USP30 in determining the threshold for mitochondrial cell death and suggest USP30 as a potential target for combinatorial anti-cancer therapy.
The mechanism by which parkin, an E3 ubiquitin ligase, and USP30, a mitochondrion-localized deubiquitylase, regulate mitophagy, was investigated.
reducing USP30 activity enhances mitochondrial degradation in neurons
USP30 participates in the maintenance of mitochondrial morphology, a finding that provides new insight into the cellular function of deubiquitination.
The distal ubiquitin-recognition mechanism of USP30 is similar to those of other USP family members, whereas Phe4 and Thr12 of the proximal ubiquitin are recognized by a USP30-specific surface.
USP30, a member of the ubiquitin-specific protease family (see USP1, MIM 603478), is a novel mitochondrial deubiquitinating (DUB) enzyme (Nakamura and Hirose, 2008
ubiquitin specific peptidase 30
, ubiquitin specific protease 30
, ubiquitin carboxyl-terminal hydrolase 30
, Ub-specific protease 30
, Ubiquitin thioesterase 30
, Deubiquitinating enzyme 30
, Ubiquitin-specific protease 30
, ubiquitin-specific-processing protease 30
, ubiquitin carboxyl-terminal hydrolase 30-like
, deubiquitinating enzyme 30
, ub-specific protease 30
, ubiquitin thioesterase 30
, ubiquitin thiolesterase 30
, ubiquitin-specific protease 30