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Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes.
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Human Polyclonal USP46 Primary Antibody for IHC, IHC (p) - ABIN4364609
Ohashi, Holthaus, Calderwood, Lai, Krastins, Sarracino, Johannsen: The EBNA3 family of Epstein-Barr virus nuclear proteins associates with the USP46/USP12 deubiquitination complexes to regulate lymphoblastoid cell line growth. in PLoS pathogens 2015
we identified USP12 and USP46 as histone H2A and H2B deubiquitinases that regulate Xenopus development
Results suggest role for USP46/USP12 (show USP12 Antibodies) in Epstein-Barr virus induced growth transformation.
USP46-mediated stabilization of PHLPP (show PHLPP1 Antibodies) and the subsequent inhibition of Akt (show AKT1 Antibodies).
results suggest that the USP46 gene might play a role in the pathophysiology of major depressive disorder in the Japanese population.
These data argue against the presence of any strong genetic susceptibility factors for bipolar disorder or schizophrenia in the region USP46.
two novel multisubunit deubiquitinating enzyme complexes containing USP12 (show USP12 Antibodies) and USP46, respectively. Both complexes contain the UAF1 (show WDR48 Antibodies) protein as a bona fide subunit. Interestingly, UAF1 (show WDR48 Antibodies)
Usp46 mutation is associated with Impaired Maternal Behavior.
Usp46 regulates a wide range of behavioral phenotypes that might be related to mental disorders
results suggest that the Lys (show LYZ Antibodies) 92 deletion of USP46 could influence enzyme activity and thereby provide a molecular clue how the enzyme regulating the pathogenesis of mental illnesses.
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004
ubiquitin carboxyl-terminal hydrolase 46
, ubiquitin specific protease 46
, deubiquitinating enzyme 46
, ubiquitin thioesterase 46
, ubiquitin thiolesterase 46
, ubiquitin-specific-processing protease 46
, ubiquitin specific peptidase 46