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Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins.
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Human Polyclonal USP5 Primary Antibody for IHC (p), WB - ABIN1882150
Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002
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Human Polyclonal USP5 Primary Antibody for IP, WB - ABIN262235
Reverdy, Conrath, Lopez, Planquette, Atmanene, Collura, Harpon, Battaglia, Vivat, Sippl, Colland: Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme. in Chemistry & biology 2012
Human Monoclonal USP5 Primary Antibody for WB - ABIN1944895
Falquet, Paquet, Frutiger, Hughes, Hoang-Van, Jaton: cDNA cloning of a human 100 kDa de-ubiquitinating enzyme: the 100 kDa human de-ubiquitinase belongs to the ubiquitin C-terminal hydrolase family 2 (UCH2). in FEBS letters 1996
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USP5 regulates c-Maf (show MAF Antibodies) stability and multiple myeloma cell survival.
study demonstrates that USP5 plays a critical role in tumorigenesis and progression of pancreatic cancer by stabilizing FoxM1 (show FOXM1 Antibodies) protein, and provides a rationale for USP5 being a potential therapeutic approach against pancreatic ductal adenocarcinoma
Taken together, our study for the first time clarified that the E3 ligase Smurf1 regulates USP5 protein stability and USP5-mediated TNF-alpha production through the ubiquitin proteasome pathway.
A ubiquitin shuttle DC-UbP reconciles protein ubiquitination and deubiquitination via linking UbE1 (show UBA1 Antibodies) and USP5 enzymes.
Used IM-MS analysis to study conformational flexibility of the multidomain deubiquitinating enzyme ubiquitin specific protease 5 (USP5).
Charge-state distribution and ion mobility analysis revealed that both mono- and tetra-ubiquitin bound to the compact conformation of USP5 only.
Cellular isopeptidase T deubiquitinating enzyme disassembles free ubiquitin chains to facilitate KSHV K7 degradation.
polyubiquitin (show UBB Antibodies) chains by USP5 at sites of damage is important for efficient DSB repair
Local administration of NO may prevent neointimal hyperplasia by inhibiting isopeptidase T levels and activity in the vasculature, thereby inhibiting the 26S proteasome (show Psmd4 Antibodies) in vascular smooth muscle cells.
Production of the USP5 isoform 2 was strongly correlated with PTBP1 (show PTBP1 Antibodies) expression in glioblastoma tumor samples and cell lines.
Sensitization was relieved by pharmacological block of TRPV1 (show TRPV1 Antibodies) afferents, but not of myelinated neurons. In spinal cord slice recordings, we could optogenetically trigger an activity-dependent potentiation of presynaptic neurotransmission in the spinal dorsal horn that relied on Cav3.2 (show CACNA1H Antibodies) channel activity. This neuronal-activity-induced USP5 upregulation may underlie a protective, transient sensitization of the pain pathway.
Suramin and Cav3.2 (show CACNA1H Antibodies)/USP5 Tat (show TAT Antibodies)-disruptor peptides were also tested in models of diabetic neuropathy and visceral pain, and provided remarkable protection
Knockdown and overexpression studies demonstrated that Usp5 regulates p53 (show TP53 Antibodies) (and p73 (show ARHGAP24 Antibodies)) levels and alters cell growth and cell cycle distribution associated with p21 (show D4S234E Antibodies) induction.
Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995
ubiquitin carboxyl-terminal hydrolase 5
, Ubiquitin isopeptidase T
, ubiquitin specific peptidase 5 (isopeptidase T) isoform 1
, ubiquitin specific peptidase 5 (isopeptidase T) isoform 2
, ubiquitin specific protease 5
, ubiquitin specific peptidase 5
, deubiquitinating enzyme 5
, isopeptidase T
, ubiquitin isopeptidase T
, ubiquitin specific protease 5 (isopeptidase T)
, ubiquitin thioesterase 5
, ubiquitin thiolesterase 5
, ubiquitin-specific protease-5 (ubiquitin isopeptidase T)
, ubiquitin-specific-processing protease 5
, ubiquitin carboxy terminal hydrolase T