Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) Proteins (USP7)

Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, PTEN and DAXX. Additionally we are shipping USP7 Antibodies (230) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse USP7 USP7 252870 Q6A4J8
USP7 7874 Q93009
Rat USP7 USP7 360471 Q4VSI4
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Top USP7 Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,984.89
Details
Baculovirus infected Insect Cells Human GST tag,His tag SDS-PAGE 100 μg Log in to see 20 to 21 Days
$437.80
Details
Baculovirus infected Insect Cells Human GST tag,His tag 100 μg Log in to see 20 to 21 Days
$140.80
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 to 8 Days
$379.50
Details
Insect cells (Sf21) Human His tag   25 μg Log in to see 5 to 8 Days
$777.69
Details
Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Log in to see 15 to 18 Days
$717.00
Details

USP7 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , , ,

More Proteins for Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) Interaction Partners

Fruit Fly (Drosophila melanogaster) Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) interaction partners

  1. reveal a conserved mechanism by which Ci/Gli (show GLI1 Proteins) is stabilized by a deubiquitination enzyme and identify Usp7/HUASP as a critical regulator of Hh signaling and potential therapeutic target for Hh-related cancers

  2. Genetic and gene expression analyses suggested that GMPS (show GMPS Proteins)/USP7 acts as a transcriptional corepressor

  3. GMP synthetase (show GMPS Proteins) stimulates histone H2B deubiquitylation by the epigenetic silencer USP7

Mouse (Murine) Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) interaction partners

  1. Evidence shows that USP7 localizes to replication foci independently of DNMT1 (show DNMT1 Proteins) and indicates that USP7 does not control cell cycle-dependent levels of DNMT1 (show DNMT1 Proteins).

  2. Pit1 (show POU1F1 Proteins) deletion inhibited USP7/IRS1 (show IRS1 Proteins) dissociation upon insulin (show INS Proteins) stimulation.

  3. EPOP (E130012A19Rik) interacts with elongin B (show TCEB2 Proteins), elongin C (show TCEB1 Proteins), and USP7 to modulate the chromatin landscape.

  4. USP7 is overexpressed and regulates homologous recombination repair in chronic lymphocytic leukemia cells.

  5. Findings demonstrate a crucial role of HAUSP in regulating N-Myc (show MYCN Proteins) function in neuroblastoma (show ARHGEF16 Proteins) in vivo and suggest that HAUSP inhibition is a potential therapy for MYCN (show MYCN Proteins)-amplified tumors.

  6. The present study identified USP7 and TDP-43 (show TARDBP Proteins) as the regulators of CRY1 (show CRY1 Proteins) and CRY2 (show CRY2 Proteins), underscoring the significance of the stability control process of CRY (show CRY2 Proteins) proteins for period determination in the mammalian circadian clockwork.

  7. demonstrate that genotoxic stress stimulates Cry1 (show CRY1 Proteins) phosphorylation and its deubiquitination by Herpes virus associated ubiquitin-specific protease (Hausp, a.k.a Usp7), stabilizing Cry1 (show CRY1 Proteins) and shifting circadian clock time

  8. Our results demonstrate that the SCML2 (show SCML2 Proteins)/USP7 complex constitutes a novel molecular pathway in modulating the epigenetic state of sex chromosomes during male meiosis

  9. USP7-mediated mono-deubiquitination of FoxO1 (show FOXO1 Proteins) results in suppression of FoxO1 (show FOXO1 Proteins) transcriptional activity through decreased FoxO1 (show FOXO1 Proteins) occupancy on the promoters of gluconeogenic genes.

  10. Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60 (show KAT5 Proteins).

Human Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) interaction partners

  1. show that BRE (show BRE Proteins) facilitates deubiquitylation of CDC25A (show CDC25A Proteins) by recruiting ubiquitin-specific-processing protease 7 (USP7) in the presence of DNA damage

  2. High expression of USP7 is frequent in HCC (show FAM126A Proteins) tissues, which promotes tumor proliferation and invasion, and is correlated with a poor overall survival.

  3. REVIEW: USP7 plays crucial roles in diverse array of cellular and biological processes including tumour suppression, cell cycle, DNA repair, chromatin remodelling, and epigenetic regulation.

  4. USP7 depletion in APC (show APC Proteins)-mutated colorectal cancer inhibits Wnt (show WNT2 Proteins) activation by restoring beta-catenin (show CTNNB1 Proteins) ubiquitination, drives differentiation, and suppresses xenograft tumor growth.

  5. USP7 is RNF169 (show RNF169 Proteins) interacting protein.Expression of USP7 and RNF169 (show RNF169 Proteins) positively correlated in breast cancer.

  6. protein deubiquitinase USP7 is an essential player in osteogenic differentiation of Human adipose-derived stem cells.

  7. ubiquitin-specific protease 7 (USP7) deubiquitinase targeting by vIRF-3 (in addition to previously reported USP7 binding by vIRF-1 and vIRF-4); the importance of vIRF-1 and vIRF-3 interactions with USP7 for latent PEL cell growth and viability; and the positive and negative contributions, respectively, of USP7 targeting by vIRF-1 and vIRF-3 to HHV-8 productive replication.

  8. demonstrate that both USP7 and various USP7 substrates are subjected to Lys48-mediated ubiquitin modification, consistent with increased proteasomal degradation of these proteins because of USP7 inhibition

  9. Here we study the transition between USP7 states. We provide a crystal structure of USP7(CD123 (show IL3RA Proteins)) and show that catalytic domain CD and the first 3 Ubl domains Ubl123 are connected via an extended charged alpha helix. Mutational analysis is used to determine whether the charge and rigidity of this 'connector helix' are important for full USP7 activity

  10. the overexpression of USP7 might promote cell proliferation by deubiquitinating Ki-67 (show MKI67 Proteins) protein

USP7 Protein Profile

Protein Summary

Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (By similarity).

Gene names and symbols associated with USP7

  • Ubiquitin-specific protease 7 (Usp7)
  • ubiquitin carboxyl-terminal hydrolase 7 (LOC100201254)
  • ubiquitin specific peptidase 7 (USP7)
  • ubiquitin specific peptidase 7 (Usp7)
  • 2210010O09Rik protein
  • AA409944 protein
  • AA617399 protein
  • AU019296 protein
  • AW548146 protein
  • C80752 protein
  • CG1490 protein
  • Dmel\\CG1490 protein
  • HAUSP protein
  • TEF1 protein
  • UBP protein
  • USP7 protein

Protein level used designations for USP7

CG1490-PB , Usp7-PB , ubiquitin specific peptidase 7 (herpes virus-associated) , ubiquitin carboxyl-terminal hydrolase 7-like , deubiquitinating enzyme 7 , herpesvirus-associated ubiquitin-specific protease , mHAUSP , ubiquitin carboxyl-terminal hydrolase 7 , ubiquitin specific protease 7 , ubiquitin thioesterase 7 , ubiquitin thiolesterase 7 , ubiquitin-specific-processing protease 7 , Herpes virus-associated ubiquitin-specific protease , ubiquitin specific protease 7 (herpes virus-associated) , herpes-virus-associated ubiquitin-specific protease , rHAUSP , ubiquitin-specific peptidase 7

GENE ID SPECIES
32169 Drosophila melanogaster
100201254 Hydra magnipapillata
100468835 Ailuropoda melanoleuca
252870 Mus musculus
7874 Homo sapiens
360471 Rattus norvegicus
395126 Gallus gallus
479854 Canis lupus familiaris
100190899 Sus scrofa
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