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Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, PTEN and DAXX. Additionally we are shipping USP7 Antibodies (210) and many more products for this protein.
Showing 8 out of 9 products:
reveal a conserved mechanism by which Ci/Gli (show GLI1 Proteins) is stabilized by a deubiquitination enzyme and identify Usp7/HUASP as a critical regulator of Hh signaling and potential therapeutic target for Hh-related cancers
Genetic and gene expression analyses suggested that GMPS (show GMPS Proteins)/USP7 acts as a transcriptional corepressor
GMP synthetase (show GMPS Proteins) stimulates histone H2B deubiquitylation by the epigenetic silencer USP7
Pit1 (show POU1F1 Proteins) deletion inhibited USP7/IRS1 (show IRS1 Proteins) dissociation upon insulin (show INS Proteins) stimulation.
EPOP (E130012A19Rik) interacts with elongin B (show TCEB2 Proteins), elongin C (show TCEB1 Proteins), and USP7 to modulate the chromatin landscape.
USP7 is overexpressed and regulates homologous recombination repair in chronic lymphocytic leukemia cells.
Findings demonstrate a crucial role of HAUSP in regulating N-Myc (show MYCN Proteins) function in neuroblastoma (show ARHGEF16 Proteins) in vivo and suggest that HAUSP inhibition is a potential therapy for MYCN (show MYCN Proteins)-amplified tumors.
The present study identified USP7 and TDP-43 (show TARDBP Proteins) as the regulators of CRY1 (show CRY1 Proteins) and CRY2 (show CRY2 Proteins), underscoring the significance of the stability control process of CRY (show CRY2 Proteins) proteins for period determination in the mammalian circadian clockwork.
demonstrate that genotoxic stress stimulates Cry1 (show CRY1 Proteins) phosphorylation and its deubiquitination by Herpes virus associated ubiquitin-specific protease (Hausp, a.k.a Usp7), stabilizing Cry1 (show CRY1 Proteins) and shifting circadian clock time
Our results demonstrate that the SCML2 (show SCML2 Proteins)/USP7 complex constitutes a novel molecular pathway in modulating the epigenetic state of sex chromosomes during male meiosis
USP7-mediated mono-deubiquitination of FoxO1 (show FOXO1 Proteins) results in suppression of FoxO1 (show FOXO1 Proteins) transcriptional activity through decreased FoxO1 (show FOXO1 Proteins) occupancy on the promoters of gluconeogenic genes.
Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60 (show KAT5 Proteins).
The ubiquitination-deubiquitination cascade mediated by the TRIM27 (show RFP Proteins)-USP7 complex plays an important role in TNF-alpha (show TNF Proteins)-induced apoptosis.
demonstrate that both USP7 and various USP7 substrates are subjected to Lys48-mediated ubiquitin modification, consistent with increased proteasomal degradation of these proteins because of USP7 inhibition
Here we study the transition between USP7 states. We provide a crystal structure of USP7(CD123 (show IL3RA Proteins)) and show that catalytic domain CD and the first 3 Ubl domains Ubl123 are connected via an extended charged alpha helix. Mutational analysis is used to determine whether the charge and rigidity of this 'connector helix' are important for full USP7 activity
the overexpression of USP7 might promote cell proliferation by deubiquitinating Ki-67 (show MKI67 Proteins) protein
these data identify DUB3 (show USP17L2 Proteins) and USP7 as factors that regulate DNA replication by controlling Geminin protein (show GMNN Proteins) stability, and suggest that USP7 may be involved in Geminin (show GMNN Proteins) dysregulation during breast cancer progression.
Molecular mechanisms of USP7 substrate recognition and C-terminal activation have been described.
USP7 promotes breast carcinogenesis by stabilizing PHF8 (show PHF8 Proteins) and upregulating cyclin A2 (show CCNA2 Proteins). and the interaction between USP7 and PHF8 (show PHF8 Proteins) is augmented during DNA damage.
Data suggest that SIRT7 (show SIRT7 Proteins) undergoes Lys (show LYZ Proteins)-63 polyubiquitination, later removed by USP7 to repress enzymatic activity of SIRT7 (show SIRT7 Proteins); USP7 and SIRT7 (show SIRT7 Proteins) regulate gluconeogenesis via expression of glucose-6-phosphatase catalytic subunit (G6PC (show G6PC Proteins)); SIRT7 (show SIRT7 Proteins) targets G6PC (show G6PC Proteins) promoter through ELK4 (show ELK4 Proteins). (SIRT7 (show SIRT7 Proteins) = sirtuin 7 (show SIRT7 Proteins); USP7 = ubiquitin specific peptidase 7; G6PC (show G6PC Proteins) = glucose-6-phosphatase catalytic subunit (show G6PC Proteins); ELK4 (show ELK4 Proteins) = transcription factor ELK4 (show ELK4 Proteins))
findings suggest that Usp7 is important for MB cell proliferation and metastasis by activating Shh (show SHH Proteins) pathway, and is a putative therapeutic target for MBs (show PPP1R12A Proteins)
Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (By similarity).
, ubiquitin specific peptidase 7 (herpes virus-associated)
, ubiquitin carboxyl-terminal hydrolase 7-like
, deubiquitinating enzyme 7
, herpesvirus-associated ubiquitin-specific protease
, ubiquitin carboxyl-terminal hydrolase 7
, ubiquitin specific protease 7
, ubiquitin thioesterase 7
, ubiquitin thiolesterase 7
, ubiquitin-specific-processing protease 7
, Herpes virus-associated ubiquitin-specific protease
, ubiquitin specific protease 7 (herpes virus-associated)
, herpes-virus-associated ubiquitin-specific protease
, ubiquitin-specific peptidase 7