Ubiquitin Specific Peptidase 8 (USP8) ELISA Kits

Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Additionally we are shipping USP8 Antibodies (94) and USP8 Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
USP8 9101 P40818
Anti-Rat USP8 USP8 296121  
Anti-Mouse USP8 USP8 84092 Q80U87
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Top USP8 ELISA Kits at antibodies-online.com

Showing 6 out of 18 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.101 ng/mL 0.31 ng/mL - 20 ng/mL 96 Tests Log in to see 13 to 16 Days
Chicken 0.188 ng/mL 0.313-20 ng/mL   96 Tests Log in to see 12 to 14 Days
Pig 0.188 ng/mL 0.313-20 ng/mL   96 Tests Log in to see 12 to 14 Days
Monkey 0.188 ng/mL 0.313-20 ng/mL   96 Tests Log in to see 12 to 14 Days
Guinea Pig 0.094 ng/mL 0.156-10 ng/mL   96 Tests Log in to see 12 to 14 Days
Rabbit 75 pg/mL 125-8000 pg/mL   96 Tests Log in to see 12 to 14 Days

More ELISA Kits for USP8 Interaction Partners

Human Ubiquitin Specific Peptidase 8 (USP8) interaction partners

  1. High expression of USP8 was correlated with advanced tumor stage and high recurrence risk. Moreover, USP8 was identified as a novel independent prognostic factor for CSCC (show CYP11A1 ELISA Kits) patients.

  2. In summary, we show that, contrary to the pituitary ACTH (show POMC ELISA Kits)-secreting tumors, the USP8 hotspot sequence on exon 14 is not mutated in tumors causing ectopic ACTH (show POMC ELISA Kits) secretion syndrome (EAS). Although USP8 is expressed in all EAS tumors examined, our in vitro data indicate that it is not involved in the regulation of ectopic proopiomelanocortin (show POMC ELISA Kits) transcription.

  3. USP8 deubiquitinates Sec31A and inhibits the formation of large COPII carriers, thereby suppressing collagen IV (show COL4 ELISA Kits) secretion.

  4. review: role of USP8 driver mutations in Cushing's Disease

  5. Data (including data from studies using knockout and transgenic mice/cells) suggest that CLEC16A, NRDP1, and USP8 form tripartite complex; CLEC16A-NRDP1-USP8 complex appears to rely on ubiquitin signals to promote mitophagy and maintain mitochondrial function necessary for beta-cell function. (CLEC16A = C-type lectin domain family 16 member A; NRDP1 = ubiquitin-protein ligase (show UBE2K ELISA Kits) NRDP1; USP8 = ubiquitin specific peptidase 8)

  6. the EGFR (show EGFR ELISA Kits)-USP8-trichoplein-Aurora A (show AURKA ELISA Kits) axis is a critical signaling cascade that restricts ciliogenesis in dividing cells, and functions to facilitate cell proliferation

  7. in human cells, Usp8 knockdown increased the lysosomal degradation of alpha-synuclein.

  8. Overexpression of USP8 in lung adenocarcinoma is an early event during the course of tumor progression, and is related to EGFR (show EGFR ELISA Kits) expression.

  9. Somatic mutations in USP8 are common in Nelson's tumors, and are associated with less favorable outcome after surgery.

  10. Data indicate that USP8 functions as a novel deubiquitylase of FLIPL and inhibits extrinsic apoptosis by stabilizing FLIPL.

Mouse (Murine) Ubiquitin Specific Peptidase 8 (USP8) interaction partners

  1. the membrane receptor MET, described herein for the first time in spermatids, is a USP8/UBPy-target substrate is delivered to the acrosome.

  2. in neuronal cells USP8 could be involved in endosomal trafficking, retrograde transport and synaptic plasticity. In disorders leading to neurodegeneration USP8 is upregulated and could influence the neuron-oligodendrocyte interactions.

  3. The spatio-temporal expression of mUBPy suggests that the enzyme may be involved in neuroregulatory processes during embryogenesis.

  4. a role for the USP8.STAM complex as a protective mechanism regulating early endosomal sorting of EGFR (show EGFR ELISA Kits) between pathways destined for lysosomal degradation and recycling.

  5. USP8 was able to interact with spermatid endosomal-sorting complex required for transport-0 and microtubule structures; USP8 can directly link, via its MIT domain, the labeled vesicles/developing acrosome to microtubules.

  6. in wobbler testis expression of mouse ubiquitin-specific processing protease (mUBPy)is up-regulated, while a differential sorting of the protein characterizes wobbler spermatids where acrosome formation is impaired

  7. Data indicate a novel mechanism where diacylglycerol kinase delta (show DGKD ELISA Kits) and protein kinase (show CDK7 ELISA Kits) Calpha (show PRKACA ELISA Kits) modulate the levels of ubiquitinated epidermal growth factor (show EGF ELISA Kits) receptors through Akt (show AKT1 ELISA Kits) and ubiquitin-specific protease 8.

  8. deubiquitinating enzyme specifically expressed in testis, associates with the acrosome and centrosome in mouse germ cells

  9. Results indicate that Nrdp1 is a specific target for the USP8 deubiquitinating enzyme and are consistent with a model where USP8 augments Nrdp1 activity by mediating its stabilization.

  10. We conclude that UBPY negatively regulates the rate of EGFR (show EGFR ELISA Kits) down-regulation by deubiquitinating EGFR (show EGFR ELISA Kits) on endosomes.

USP8 Antigen Profile

Antigen Summary

Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1.

Gene names and symbols associated with USP8

  • ubiquitin carboxyl-terminal hydrolase 8 (LOC9310109) antibody
  • ubiquitin carboxyl-terminal hydrolase 8 (MGYG_00369) antibody
  • ubiquitin specific peptidase 8 (USP8) antibody
  • ubiquitin specific peptidase 8 (Usp8) antibody
  • AI574262 antibody
  • AW557536 antibody
  • HumORF8 antibody
  • mKIAA0055 antibody
  • Ubpy antibody

Protein level used designations for USP8

ubiquitin carboxyl-terminal hydrolase 8 , ubiquitin-specific-processing protease 8 , ubiquitin specific peptidase 8 , ubiquitin carboxyl-terminal hydrolase 8-like , deubiquitinating enzyme 8 , hUBPy , ubiquitin isopeptidase Y , ubiquitin specific protease 8 , ubiquitin thioesterase 8 , ubiquitin thiolesterase 8 , putative deubiquitinating enzyme

9310109 Arabidopsis lyrata subsp. lyrata
10031598 Arthroderma gypseum CBS 118893
100408559 Callithrix jacchus
100437819 Pongo abelii
9101 Homo sapiens
296121 Rattus norvegicus
84092 Mus musculus
100157546 Sus scrofa
415451 Gallus gallus
100351436 Oryctolagus cuniculus
100720255 Cavia porcellus
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