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Human Ubiquitin-Conjugating Enzyme E2B (UBE2B) interaction partners
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RAD6 is upregulated in response to chemotherapy and significantly correlated with expression of ovarian cancer (OC) stem cell signaling genes ALDH1A1 and SOX2 and poor prognosis of OC patients.
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These data deepen insights into the vital role of RAD6/translesion synthesis in platinum drug tolerance and reveal clinical benefits of targeting RAD6 with SMI#9 for managing chemoresistant cancers.
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These results point to an important role of the affinity between RNF4 and its cognate RAD6B or UBCH5B in governing the multiplicity of substrate ubiquitination.
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RAD6 promotes proteasome activity and nuclear translocation by enhancing the degradation of PSMF1 and the lamin B receptor.
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In conclusion, we reveal that miR-455-5p expression is regulated by the TGF-beta-dependent pathway, which subsequently leads to UBE2B down-regulation and contributes to oral cancer tumourigenesis.
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Data show that the ubiquitin-conjugating enzyme E2 RAD6A/B-MDM2 ubiquitin ligase machinery regulates anti-silencing function 1A protein (ASF1A) degradation.
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These findings show the importance of Rad6 in ovarian cancer and emphasize the need for further studies of Rad6 as a potential target for the treatment of ovarian cancer.
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A novel variant (Chr5.133706925 A > G) residing in the UBE2B gene promoter region confers a high risk for idiopathic azoospermia in a Chinese population.
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RAD6 physically interacts with heterochromatin protein 1alpha and ubiquitinates HP1alpha at residue K154, thereby promoting heterochromatin protein 1alpha degradation through the autophagy pathway
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UBE2B mRNA alterations are associated with severe oligozoospermia in infertile men.
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RNF168, in complex with RAD6A or RAD6B, is activated in the DNA-damage-induced protein ubiquitination cascade.
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UBE2B polymorphisms g.-293T>G, g.20016A>G and g.9157A>G are not associated with male infertility, and the GA haplotype is likely a protective factor for male fertility in Northeast Chinese men.
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beta-catenin and Rad6B interacting regions, were identified.
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Hydroquinone could upregulate the expression of Rad6B in L-02 hepatic cells.
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The Rad6-Rad18 enzyme plays an essential role in promoting replication through DNA lesions by translesion synthesis in mammalian cells.
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RAD6 can form a ternary complex with MDM2 and p53 that contributes to the degradation of p53.
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Data show that the homodimeric Rad18 RING domain can recruit two Rad6b E2 enzymes, whereas the full-length Rad18 homodimer binds only to a single Rad6b molecule.
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Ubc2/Rad6 ser(120) regulates ubiquitin-dependent N-end rule targeting by E3{alpha}/Ubr1
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Rad6B is a fundamental component of postreplication DNA repair and can be used as an independent marker for determining response to neoadjuvant chemotherapy.
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MCF10A cells stably transfected with antisense RAD6B display hypersensitivity to damage-inducing drugs.
Mouse (Murine) Ubiquitin-Conjugating Enzyme E2B (UBE2B) interaction partners
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Results reveal that RAD6B and RNF8 contribute to nucleosome removal during spermiogenesis.
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RNF168, in complex with RAD6A or RAD6B, is activated in the DNA-damage-induced protein ubiquitination cascade.
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These results suggest that Ube2b, as a direct androgen receptor transcriptional target in Sertoli cells, mediates the function of androgen recpetor in spermatogenesis by promoting H2A ubiquitylation.
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HR6B represses major satellite repeat transcription in spermatocytes, and functions in the maintenance of X chromosome silencing in spermatocytes and spermatids.
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The present findings reveal a specific requirement for the ubiquitin-conjugating activity of HR6B in relation to dynamic aspects of the synaptonemal complex and meiotic recombination in spermatocytes.
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Ube2b deficient mice are shown to present male infertility and sperm head shape anomalies.
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HR6B exerts control over different histone modifications in spermatocytes and spermatids, and that this function contributes to the postmeiotic maintenance of X chromosome silencing.
UBE2B Antigen Profile
Antigen Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.
Gene names and symbols associated with UBE2B
- ubiquitin conjugating enzyme E2 B (UBE2B) antibody
- ubiquitin-conjugating enzyme E2B (Ube2b) antibody
- ubiquitin conjugating enzyme E2 B (ube2b) antibody
- ubiquitin-conjugating enzyme E2B (RAD6 homolog) (ube2b) antibody
- ubiquitin conjugating enzyme E2 B S homeolog (ube2b.S) antibody
- 2610301N02Rik antibody
- E2-14k antibody
- e2-17kda antibody
- hhr6b antibody
- hr6b antibody
- mHR6B antibody
- Rad6b antibody
- ubc2 antibody
- zgc:100921 antibody
Protein level used designations for UBE2B
E2 protein , RAD6 homolog B , ubiquitin carrier protein B , ubiquitin-conjugating enzyme E2 B , ubiquitin-conjugating enzyme E2-17 kDa , ubiquitin-conjugating enzyme E2B (RAD6 homolog) , ubiquitin-protein ligase B , E2(14k) , ubiquitin conjugating enzyme , ubiquitin-conjugating enzyme E2(14k) , ubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae) , ubiquitin-conjugating enzyme E2B, RAD6 homolog , ubiquitin-conjugating enzyme E2B, RAD6 homology , HR6B , ubiquitin conjugating-protein , Ubiquitin-conjugating enzyme E2 B , ubiquitin-conjugating enzyme E2 , E214K
GENE ID | SPECIES |
---|---|
7320 | Homo sapiens |
512207 | Bos taurus |
474683 | Canis lupus familiaris |
81816 | Rattus norvegicus |
100009132 | Oryctolagus cuniculus |
448706 | Xenopus (Silurana) tropicalis |
462065 | Pan troglodytes |
100286422 | Salmo salar |
100301680 | Oncorhynchus mykiss |
437020 | Danio rerio |
443745 | Xenopus laevis |
710678 | Macaca mulatta |
100381250 | Ovis aries |
22210 | Mus musculus |
100513527 | Sus scrofa |
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