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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Additionally we are shipping UBE2E1 Antibodies (21) and many more products for this protein.
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UBE2E1 expression was adversely correlated with AML (show RUNX1 Proteins) survival; UBE2E1 expression was negatively correlated with patients' response to induction chemotherapy
IPO11 provides protection in another way, the researchers found. The transport receptor also shuttles UBE2E1, an enzyme necessary for PTEN ubiquitination, into the nucleus. Thanks to IPO11, normal cells keep all of their UBE2E1 in the nucleus, allowing PTEN to continue functioning in the cytoplasm. In cells lacking IPO11, UBE2E1 remains in the cytoplasm and promotes the destruction of PTEN.
study reveals that UbE2E1 is an in vivo E2 for the PRC1 (show PRC1 Proteins) ligase complex and thus plays an important role in the regulation of H2A Lys (show LYZ Proteins)-119 monoubiquitination
Auto-ubiquitination of Ube2E1 is intramolecular.RNF4 enhances Ube2E1 self-ubiquitination.
USP7 (show USP7 Proteins) is critical in maintaining the steady state levels of UbE2E1 in cells.
isolated ISG15-modified and unmodified UbcH6 proteins, and analyzed their abilities to form thioester intermediates with ubiquitin
UbcH6 and ataxin-1 are E2-substrate cognate pairs in the ubiquitin-proteasome system.
UbcH6 modulates the transcriptional repression activity of ataxin-1 (show ATXN1 Proteins) by modulating the degradation of ataxin-1 (show ATXN1 Proteins).
Ro52 (show TRIM21 Proteins) has both cytoplasmic and nuclear substrates, and mediates ubiquitination through UBE2D1 (show UBE2D1 Proteins) in the cytoplasm and through UBE2E1 in the nucleus.
UbcM2 (show UBE2E3 Proteins) may play potential roles in the development of mouse diverse tissues and organs, particularly in the development of brain and skeleton.
UBE2E3 (show UBE2E3 Proteins) is essential for the proliferation of RPE-1 (show PMEL Proteins) cells and is downregulated during RPE (show RPE Proteins) layer maturation in the developing mouse eye.
UbcM2, in concert with substrate adaptors, engages activated cullin3 ligases, thus suggesting that class III ubiquitin conjugating enzymes are novel regulators of cullin ligases.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog)
, ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)
, ubiquitin-conjugating enzyme E2E 1
, ubiquitin carrier protein E1
, ubiquitin-conjugating enzyme E2 E1
, ubiquitin-conjugating enzyme E2E 1 (homologous to yeast UBC4/5)
, ubiquitin-protein ligase E1
, ubiquitin-conjugating enzyme 5
, ubiquitin-conjugating enzyme E2E 1, UBC4/5 homolog