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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.
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Human Polyclonal UBE2L3 Primary Antibody for WB - ABIN1881966
Amidon, Hawley: Oral bioperformance and 21st century dissolution. in Molecular pharmaceutics 2013
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Human Polyclonal UBE2L3 Primary Antibody for IHC (p), WB - ABIN1882145
Moynihan, Ardley, Leek, Thompson, Brindle, Markham, Robinson: Characterization of a human ubiquitin-conjugating enzyme gene UBE2L3. in Mammalian genome : official journal of the International Mammalian Genome Society 1996
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Cow (Bovine) Polyclonal UBE2L3 Primary Antibody for IHC, WB - ABIN2775684
Collins, Wright, Edwards, Davis, Grinham, Cole, Goward, Aguado, Mallya, Mokrab, Huckle, Beare, Dunham: A genome annotation-driven approach to cloning the human ORFeome. in Genome biology 2004
Human Polyclonal UBE2L3 Primary Antibody for ICC, IF - ABIN250651
Mayca Pozo, Tang, Bonk, Keri, Yao, Zhang: Regulatory cross-talk determines the cellular levels of 53BP1 protein, a critical factor in DNA repair. in The Journal of biological chemistry 2017
Crystal structure of HHARI (show ARIH1 Antibodies) and UbcH7 reveals UbcH7 approximately Ub binding RING1 (show RING1 Antibodies) domain of auto-inhibited HHARI (show ARIH1 Antibodies).
Data suggest ordered binding of UBCH7-ubiquitin to E6AP (show ube3a Antibodies) Site 1 (for E6AP (show ube3a Antibodies)-Cys820/ubiquitin thioester formation) and E6AP (show ube3a Antibodies) Site 2 (for subsequent chain elongation); proximal indexation accounts for radially symmetric structure of E6AP (show ube3a Antibodies), requirement for oligomerization in polyubiquitin (show UBB Antibodies) chain formation, and mechanistic rationale for Cys820-ubiquitin thioester as platform in chain assembly. (E6AP (show ube3a Antibodies) = ubiquitin-protein ligase (show UBE2K Antibodies) E6AP (show ube3a Antibodies))
The TCGGC haplotype is associated with an increased risk of Hashimoto Thyroiditis(HT) and UBE2L3 gene is likely to be a susceptibility factor to HT in a Chinese Han population.
together with UBE2N (show UBE2N Antibodies) and UBE2D2 (show UBE2D2 Antibodies), synergistically contribute to Parkin (show PARK2 Antibodies)-mediated mitophagy
The MAP1B-LC1 (show MAP1B Antibodies) could interact with the ubiquitin-conjugating E2 enzyme UBE2L3 and that the ubiquitination/degradation mechanism triggered by MAP1B-LC1 (show MAP1B Antibodies) could be prevented by inhibiting the ubiquitin-proteasome proteolytic pathway.
An interaction between LC1 (show MAP1B Antibodies) and the ubiquitin-conjugating enzyme (show Ube2t Antibodies) UBE2L3.
UbcH7 has a role in regulating 53BP1 (show TP53BP1 Antibodies) stability and DSB repair
UBE2L3 polymorphism amplifies NF-kappaB (show NFKB1 Antibodies) activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases.
Report role of UBE2L3 genetic variants in confering risk of systemic lupus erythematosus in Chinese population.
Importance of HLA-C and UBE2L3 in the clearance of HBV infection in addition to HLA-DP (show HLA-DPB1 Antibodies) and HLA-DQ.
UBE2L3 depletion increases pro-IL-1beta (show IL1B Antibodies) levels.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene.
ubiquitin carrier protein L3
, ubiquitin-conjugating enzyme E2 L3
, ubiquitin-conjugating enzyme E2-F1
, ubiquitin-conjugating enzyme UBCH7
, ubiquitin-protein ligase L3
, ubiquitin-conjugating enzyme 7
, ubiquitin-conjugating enzyme E2L 3
, ubiquitin-conjugating enzyme E2L 3, like