Ubiquitin-Conjugating Enzyme E2L 3 Proteins (UBE2L3)

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Additionally we are shipping UBE2L3 Antibodies (119) and UBE2L3 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UBE2L3 7332 P68036
Mouse UBE2L3 UBE2L3 22195 P68037
Rat UBE2L3 UBE2L3 363836  
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Top UBE2L3 Proteins at antibodies-online.com

Showing 8 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Escherichia coli (E. coli) Human Un-conjugated   3 nmol 2 to 3 Days
$290.00
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
Details
Yeast Cow His tag   1 mg 60 to 71 Days
$2,343.00
Details
Escherichia coli (E. coli) Human S tag,His tag 100 μg 15 to 18 Days
$688.00
Details
Escherichia coli (E. coli) Human Un-conjugated   50 μg 2 to 3 Days
$313.85
Details
Human His tag   50 μg 6 to 8 Days
$256.30
Details

UBE2L3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,

Top referenced UBE2L3 Proteins

  1. Human UBE2L3 Protein expressed in HEK-293 Cells - ABIN2734856 : Koo, Chae, Kim, Kang, Kim, Kwak, Jung, Cho, Choi, Park, Shin, Jang, Shin, Hwang, Yi, Park: Identification of novel autoantibodies in type 1 diabetic patients using a high-density protein microarray. in Diabetes 2014 (PubMed)

More Proteins for Ubiquitin-Conjugating Enzyme E2L 3 (UBE2L3) Interaction Partners

Human Ubiquitin-Conjugating Enzyme E2L 3 (UBE2L3) interaction partners

  1. Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation.

  2. UBCH7/UBE2L3 catalyzes the conjugation of heterotypic ubiquitin chains on p27(Kip1) that are proteolytically incompetent

  3. The variant genotypes of rs4821116 in ubiquitin conjugating enzyme E2 L3 (UBE2L3) are associated with decreased risk for HBV-related hepatocellular carcinoma (HCC) and chronic hepatitis B virus (HBV) infection. Higher levels of UBE2L3 expression are correlated with higher tumor grade, advanced tumor stage and poor survival. In vitro analysis revealed that UBE2L3 may promote hepatocyte proliferation and migration.

  4. The association between the genotype of rs4821116 in the UBE2L3 gene and the reduction in viral load in pregnant women needed to be confirmed by studies with a larger sample size.

  5. Low UBE2L3 expression is associated with chikungunya fever.

  6. Crystal structure of HHARI and UbcH7 reveals UbcH7 approximately Ub binding RING1 domain of auto-inhibited HHARI.

  7. Data suggest ordered binding of UBCH7-ubiquitin to E6AP Site 1 (for E6AP-Cys820/ubiquitin thioester formation) and E6AP Site 2 (for subsequent chain elongation); proximal indexation accounts for radially symmetric structure of E6AP, requirement for oligomerization in polyubiquitin chain formation, and mechanistic rationale for Cys820-ubiquitin thioester as platform in chain assembly. (E6AP = ubiquitin-protein ligase E6AP)

  8. The TCGGC haplotype is associated with an increased risk of Hashimoto Thyroiditis(HT) and UBE2L3 gene is likely to be a susceptibility factor to HT in a Chinese Han population.

  9. together with UBE2N and UBE2D2, synergistically contribute to Parkin-mediated mitophagy

  10. The MAP1B-LC1 could interact with the ubiquitin-conjugating E2 enzyme UBE2L3 and that the ubiquitination/degradation mechanism triggered by MAP1B-LC1 could be prevented by inhibiting the ubiquitin-proteasome proteolytic pathway.

  11. An interaction between LC1 and the ubiquitin-conjugating enzyme UBE2L3.

  12. UbcH7 has a role in regulating 53BP1 stability and DSB repair

  13. UBE2L3 polymorphism amplifies NF-kappaB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases.

  14. Report role of UBE2L3 genetic variants in confering risk of systemic lupus erythematosus in Chinese population.

  15. Importance of HLA-C and UBE2L3 in the clearance of HBV infection in addition to HLA-DP and HLA-DQ.

  16. The results suggest that variants carried on the SLE-associated UBE2L3 risk haplotype influence autoimmunity by modulating UBCH7 expression.

  17. UBE2L3 was found to be a shared susceptibility gene for siffuse cutaneous systemic sclerosis in a Japanese population.

  18. The interaction between UBE2L3 genotype and autoantibodies upon serum IFN-alpha suggests a biological role for this locus in patients with systemic lupus erythematosus.

  19. Crystal structures of two bacterial E3s, Salmonella SopA and Escherichia coli NleL, both in complex with human E2 UbcH7, are reported.

  20. UBCH7 exhibits activity with the RING-in-between-RING (RBR) family of E3s that includes parkin (also known as PARK2) and human homologue of ariadne (HHARI; also known as ARIH1)

Mouse (Murine) Ubiquitin-Conjugating Enzyme E2L 3 (UBE2L3) interaction partners

  1. UBE2L3 depletion increases pro-IL-1beta levels.

UBE2L3 Protein Profile

Protein Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with UBE2L3

  • ubiquitin conjugating enzyme E2 L3 (UBE2L3)
  • ubiquitin-conjugating enzyme E2L 3 (Ube2l3)
  • ubiquitin-conjugating enzyme E2L 3a (ube2l3a)
  • ubiquitin conjugating enzyme E2 L3 S homeolog (ube2l3.S)
  • ubiquitin-conjugating enzyme E2L 3b (ube2l3b)
  • ubiquitin conjugating enzyme E2 L3 (Ube2l3)
  • C79827 protein
  • E2-F1 protein
  • L-UBC protein
  • Ubce7 protein
  • UBCH7 protein
  • UbcM4 protein
  • UBE2L3 protein
  • ube2l3l protein
  • wu:fb38h03 protein
  • wu:fc22h11 protein
  • zgc:86727 protein

Protein level used designations for UBE2L3

ubiquitin carrier protein L3 , ubiquitin-conjugating enzyme E2 L3 , ubiquitin-conjugating enzyme E2-F1 , ubiquitin-conjugating enzyme UBCH7 , ubiquitin-protein ligase L3 , ubiquitin-conjugating enzyme 7 , ubiquitin-conjugating enzyme E2L 3 , ubiquitin-conjugating enzyme E2L 3, like

GENE ID SPECIES
7332 Homo sapiens
22195 Mus musculus
363836 Rattus norvegicus
415162 Danio rerio
416769 Gallus gallus
446231 Xenopus laevis
477572 Canis lupus familiaris
697675 Macaca mulatta
748061 Pan troglodytes
767894 Bos taurus
100154268 Sus scrofa
100174693 Pongo abelii
100346312 Oryctolagus cuniculus
321943 Danio rerio
100714064 Cavia porcellus
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