Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) ELISA Kits

UBA3 encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Additionally we are shipping UBA3 Antibodies (42) and UBA3 Proteins (14) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
UBA3 9039 Q8TBC4
UBA3 117553 Q99MI7
UBA3 22200 Q8C878
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Top UBA3 ELISA Kits at antibodies-online.com

Showing 3 out of 7 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.094 ng/mL 0.15 ng/mL - 10 ng/mL A typical standard curve 96 Tests Log in to see 13 to 16 Days
$641.23
Details
Rat
  96 Tests Log in to see 11 to 18 Days
$589.86
Details
Mouse
  96 Tests Log in to see 11 to 18 Days
$589.86
Details

More ELISA Kits for UBA3 Interaction Partners

Human Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) interaction partners

  1. The study demonstrated that two mutations in UBA3 which were not previously reported confer MLN4924 resistance to MLN4924, a selective NEDD8-activating enzyme inhibitor.

  2. E1 (NAE1 and UBA3) and E2 (UBC12) enzymes, as well as global NEDD8 conjugation, were upregulated in over 2/3 of human intrahepatic cholangiocarcinoma

  3. Report role for neddylation via Nedd8-activating enzyme in the regulation of tumor angiogenesis.

  4. Demonstrated that Uba3-betaGD is an independently folded domain in solution and that residues involved in E2 binding are absent from the NMR spectrum, indicating that the E2-binding surface on Uba3-betaGD interconverts between multiple conformations.

  5. structure and mutational analysis of human APPBP1-UBA3, the heterodimeric E1 enzyme for NEDD8

  6. Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer.

  7. Data report the structure of the quaternary complex between human APPBP1-UBA3, a heterodimeric E1, its ubl NEDD8, and ATP.

  8. crystal structure of a complex between the C-terminal domain from NEDD8's heterodimeric E1 (APPBP1-UBA3) and the catalytic core domain of NEDD8's E2 (Ubc12)

  9. X-ray crystallographic analysis of APPBP1-UBA3-NEDD8 shows that APPBP1-UBA3's preference for NEDD8's Ala72 appears to be indirect, due to proper positioning of UBA3's Arg190.

UBA3 Antigen Profile

Antigen Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene names and symbols associated with UBA3

  • ubiquitin like modifier activating enzyme 3 (UBA3) antibody
  • ubiquitin-like modifier activating enzyme 3 (Uba3) antibody
  • ubiquitin-like modifier activating enzyme 3 (uba3) antibody
  • ubiquitin like modifier activating enzyme 3 (uba3) antibody
  • ubiquitin like modifier activating enzyme 3 S homeolog (uba3.S) antibody
  • A830034N06Rik antibody
  • AI256736 antibody
  • AI848246 antibody
  • AW546539 antibody
  • hUBA3 antibody
  • ube1c antibody
  • wu:fb75e04 antibody
  • wu:fc37b11 antibody
  • zgc:55528 antibody

Protein level used designations for UBA3

NEDD8-activating enzyme E1 catalytic subunit , NEDD8-activating enzyme E1C , Nedd8-activating enzyme hUba3 , UBA3, ubiquitin-activating enzyme E1 homolog , ubiquitin-activating enzyme 3 , ubiquitin-activating enzyme E1C (UBA3 homolog, yeast) , ubiquitin-activating enzyme E1C (homologous to yeast UBA3) , ubiquitin-like modifier-activating enzyme 3 , ubiquitin activating enzyme 3 , ubiquitin-activating enzyme E1C , ubiquitin-like modifier activating enzyme 3 , NEDD8-activating enzyme E1 catalytic subunit-like

GENE ID SPECIES
9039 Homo sapiens
117553 Rattus norvegicus
406776 Danio rerio
512647 Bos taurus
22200 Mus musculus
100011849 Monodelphis domestica
100196693 Salmo salar
100392131 Callithrix jacchus
100550920 Meleagris gallopavo
100566540 Anolis carolinensis
734782 Xenopus laevis
426073 Gallus gallus
476560 Canis lupus familiaris
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