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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Additionally we are shipping UBA3 Antibodies (38) and UBA3 Proteins (12) and many more products for this protein.
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The study demonstrated that two mutations in UBA3 which were not previously reported confer MLN4924 resistance to MLN4924, a selective NEDD8 (show NEDD8 ELISA Kits)-activating enzyme inhibitor.
E1 (NAE1 and UBA3) and E2 (UBC12) enzymes, as well as global NEDD8 (show NEDD8 ELISA Kits) conjugation, were upregulated in over 2/3 of human intrahepatic cholangiocarcinoma
Report role for neddylation via Nedd8 (show NEDD8 ELISA Kits)-activating enzyme in the regulation of tumor angiogenesis.
Demonstrated that Uba3-betaGD is an independently folded domain in solution and that residues involved in E2 binding are absent from the NMR spectrum, indicating that the E2-binding surface on Uba3-betaGD interconverts between multiple conformations.
structure and mutational analysis of human APPBP1-UBA3, the heterodimeric E1 enzyme for NEDD8 (show NEDD8 ELISA Kits)
Conservation in the mechanism of Nedd8 (show NEDD8 ELISA Kits) activation by the human AppBp1-Uba3 heterodimer.
Data report the structure of the quaternary complex between human APPBP1-UBA3, a heterodimeric E1, its ubl NEDD8 (show NEDD8 ELISA Kits), and ATP.
crystal structure of a complex between the C-terminal domain from NEDD8's heterodimeric E1 (APPBP1-UBA3) and the catalytic core domain of NEDD8's E2 (Ubc12)
X-ray crystallographic analysis of APPBP1-UBA3-NEDD8 (show NEDD8 ELISA Kits) shows that APPBP1-UBA3's preference for NEDD8 (show NEDD8 ELISA Kits)'s Ala72 appears to be indirect, due to proper positioning of UBA3's Arg190.
This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene of this particular family member is over 10 kb in length. The expression of these transcripts is restricted to the salivary gland among the human tissues examined. Alternate transcriptional splice variants have been characterized.
NEDD8-activating enzyme E1 catalytic subunit
, NEDD8-activating enzyme E1C
, Nedd8-activating enzyme hUba3
, UBA3, ubiquitin-activating enzyme E1 homolog
, ubiquitin-activating enzyme 3
, ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)
, ubiquitin-activating enzyme E1C (homologous to yeast UBA3)
, ubiquitin-like modifier-activating enzyme 3
, acetaldehyde dehydrogenase 8
, aldehyde dehydrogenase 8
, aldehyde dehydrogenase family 3 member B2
, ubiquitin activating enzyme 3
, ubiquitin-activating enzyme E1C
, ubiquitin-like modifier activating enzyme 3
, NEDD8-activating enzyme E1 catalytic subunit-like