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UBA3 encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Additionally we are shipping UBA3 Antibodies (43) and UBA3 Proteins (12) and many more products for this protein.
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The study demonstrated that two mutations in UBA3 which were not previously reported confer MLN4924 resistance to MLN4924, a selective NEDD8-activating enzyme inhibitor.
E1 (NAE1 and UBA3) and E2 (UBC12) enzymes, as well as global NEDD8 conjugation, were upregulated in over 2/3 of human intrahepatic cholangiocarcinoma
Report role for neddylation via Nedd8-activating enzyme in the regulation of tumor angiogenesis.
Demonstrated that Uba3-betaGD is an independently folded domain in solution and that residues involved in E2 binding are absent from the NMR spectrum, indicating that the E2-binding surface on Uba3-betaGD interconverts between multiple conformations.
structure and mutational analysis of human APPBP1-UBA3, the heterodimeric E1 enzyme for NEDD8
Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer.
Data report the structure of the quaternary complex between human APPBP1-UBA3, a heterodimeric E1, its ubl NEDD8, and ATP.
crystal structure of a complex between the C-terminal domain from NEDD8's heterodimeric E1 (APPBP1-UBA3) and the catalytic core domain of NEDD8's E2 (Ubc12)
X-ray crystallographic analysis of APPBP1-UBA3-NEDD8 shows that APPBP1-UBA3's preference for NEDD8's Ala72 appears to be indirect, due to proper positioning of UBA3's Arg190.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
NEDD8-activating enzyme E1 catalytic subunit
, NEDD8-activating enzyme E1C
, Nedd8-activating enzyme hUba3
, UBA3, ubiquitin-activating enzyme E1 homolog
, ubiquitin-activating enzyme 3
, ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)
, ubiquitin-activating enzyme E1C (homologous to yeast UBA3)
, ubiquitin-like modifier-activating enzyme 3
, ubiquitin activating enzyme 3
, ubiquitin-activating enzyme E1C
, ubiquitin-like modifier activating enzyme 3
, NEDD8-activating enzyme E1 catalytic subunit-like