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UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. Additionally we are shipping UNC5A Antibodies (45) and UNC5A Proteins (7) and many more products for this protein.
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These studies reveal an unexpected role of the axon guidance receptor UNC5A in fine-tuning ERalpha and EGFR signaling and the luminal progenitor status of hormone-sensitive breast cancers. Furthermore, UNC5A knockdown cells provide an ideal model system to investigate metastasis of ERalpha(+) breast cancers
The results suggest that netrin-1 promotes glioma cell proliferation by activating NF-kappaB signaling via UNC5A.
Such data indicate that cooperation between the UPR and UNC5A depletion as previously observed by ourselves in HCC patients samples may foster liver cancer development and growth.
UNC5A is capable of impeding autophagy and promoting HCV restriction through specific impact on virion infectivity, in a cell death-independent and DAPK-related manner.
FANCC interferes with UNC5A's functions in apoptosis and suggest that FANCC may participate in developmental processes through association with the dependence receptor UNC5A.
these data suggest an important role for UNC5A, a candidate tumor suppressor, in predicting response to DNA damage induced by chemotherapeutic drug and regulating cell death in bladder cancer
UNC5A is a novel transcriptional target of p53 and plays a role in p53-dependent apoptosis
may represent tumor suppressor that inhibit tumor extension outside the region of netrin-1 availability by inducing apoptosis
UNC5 orthologues define a new mechanism for both the positive (induction) and negative (suppression) regulation of apoptosis in cancer cells (review)
Mannosylation by DPY19L1 but not DPY19L3 is required for transport of UNC5A from the endoplasmic reticulum to the cell surface. In vertebrates, a new C-mannosyltransferase has apparently evolved to increase glycosylation of TSRs, potentially to increase the stability of the structurally essential tryptophan ladder or to provide additional adhesion functions.
Findings suggest that DCC:UNC5H ratios in DA neurons at critical periods may have important consequences for the organization and function of mesocorticolimbic DA systems.
Unc5h1 was cloned; its expression is restricted to the central nervous system in developing mouse
a mechanism for UNC5H1-mediated apoptosis that requires an interaction with the MAGE protein NRAGE
Results suggest that UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1.
UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).
unc-5 homolog A (C. elegans)
, unc-5 homolog A-like
, netrin receptor UNC5A
, netrin receptor Unc5h1
, protein unc-5 homolog 1
, protein unc-5 homolog A
, unc-5 homolog 1
, unc5 (C.elegans homolog) a
, unc5 homolog 1
, transmembrane receptor Unc5H1