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Receptor for netrin. Additionally we are shipping UNC5D Kits (4) and UNC5D Proteins (4) and many more products for this protein.
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The authors identified a locus on chromosome 8, containing UNC5D, and demonstrated evidence of its genome-wide significance with mental composite scores. Within this locus, the joint effects of two independent single nucleotide polymorphisms had a p-value of 4.38 x 10(-9) for mental composite scores.
Unc5D is thus a newly identified transcriptional target of proapoptotic p53 and may also act upstream of p53 to induce p53dependent apoptosis by phosphorylation at ser15.
the dependence receptor UNC5H4 may act as a putative tumor suppressor in neuroblastoma.
UNC5D is a functional tumor suppressor that is frequently downregulated in RCCs due to promoter hypermethylation and LOH.
UNC5D forms a positive feedback loop with p53 and E2F1 to promote NGF dependence-mediated programmed cell death during neuroblastoma regression.
UNC5H4 amplifies p53-dependent apoptotic response.
Data show that Unc5 cell guidance receptor Unc5D controls Latrophilin3 (LPHN3)-FLRT protein FLRT2-mediated cell adhesion.
Unc5d is primarily expressed by layer 4 cells in the primary sensory areas of the developing neocortex and may mediate the effect of netrin-4 on cortical cell survival in a lamina-specific manner.
Unc5h4 was cloned; its expression is in the developing limb and mammary gland in developing mouse
UNC5D protein and nuclear RNA is localized in the multipolar cells of the subventricular zone throughout cortical development.
Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).
netrin receptor UNC5D
, unc-5 homolog D (C. elegans)
, netrin receptor Unc5h4
, netrin receptor UNC5D-like
, protein unc-5 homolog 4
, protein unc-5 homolog D
, unc-5 homolog 4
, unc5 homolog 4