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UMOD encodes uromodulin, the most abundant protein in normal urine. Additionally we are shipping Uromodulin Kits (64) and Uromodulin Proteins (21) and many more products for this protein.
Showing 10 out of 183 products:
Human Polyclonal Uromodulin Primary Antibody for IHC (fro), ELISA - ABIN2476682
Conner, Mansour: Serotonin receptor-mediated activation of adenylate cyclase in the neuroblastoma NCB.20: a novel 5-hydroxytryptamine receptor. in Molecular pharmacology 1990
Show all 4 Pubmed References
Human Monoclonal Uromodulin Primary Antibody for IP, ELISA - ABIN521253
Jou, Fang, Chen, Chen, Cheng, Shen, Liao, Tsai: Proteomic study of renal uric acid stone. in Urology 2012
Show all 2 Pubmed References
Human Polyclonal Uromodulin Primary Antibody for IF, IHC (p) - ABIN521251
Larkin, Zhang, Godfrey, Molostvov, Zehnder, Rabbani, Thornalley: Glucose-induced down regulation of thiamine transporters in the kidney proximal tubular epithelium produces thiamine insufficiency in diabetes. in PLoS ONE 2013
Human Polyclonal Uromodulin Primary Antibody for IF (p) - ABIN729800
Cho, Song, Oh, Kim, Ko, Lee, Jo: Fate of Neutrophils during the Recovery Phase of Ischemia/Reperfusion Induced Acute Kidney Injury. in Journal of Korean medical science 2017
we report a novel UMOD mutation in a Brazilian family with 11 affected members, and we discuss the importance of performing genetic testing in families with inherited kidney disease of unknown cause.
Studied genetic association of uromodulin SNP in kidney function of patients with hypertension and cardiovascular disease.
Single-nucleotide polymorphism in UMOD gene is associated with type 2 diabetes.
UMOD gene variants in humans fulfill the criteria for ascribing a gene as causal of Hypertension.
The missense mutation p.142R>R/Q in the uromodulin gene in patients with cast Nephropathy in Multiple Myeloma.
Data show that one SNP (rs183962941), located in a non-coding region of uromodulin protein (UMOD), was nominally associated with end-stage renal disease (ESRD).
THP appears to participate directly in complement inactivation by its ability to act as a cofactor for C3b degradation.
High urinary uromodulin levels are associated with lower risk for UTI (show AMBP Antibodies) in older community-dwelling adults independent of traditional UTI (show AMBP Antibodies) risk factors.
The uromodulin-CFH (show CFH Antibodies) interaction enhanced the cofactor activity of CFH (show CFH Antibodies) for factor I-mediated cleavage of C3b to inactivated C3b.
These findings suggest that the levels of urinary microvesicle-bound uromodulin are associated with the severity of diabetic kidney disease.
results strongly suggest that the progressive worsening of kidney functions reflects the accumulation of the deleterious effects of the misfolded mutant THP and the compensatory responses
Endoplasmic reticulum stress and apoptosis are key features in a mouse model of kidney disease driven by the uromodulin p.Cys147Trp mutation.
Consistently, pathway enrichment analysis indicates that mutant uromodulin expression affects ER function and protein homeostasis.
we show that Tamm-Horsfall protein deficiency stimulates proximal epithelial activation of the Interleukin-23/Interleukin-17 (show IL17A Antibodies) axis and systemic neutrophilia.
TNFalpha (show TNF Antibodies) regulates uromodulin expression in a homeostatic setting, but the impact of TNFalpha (show TNF Antibodies) on uromodulin during kidney injury is superseded by other factors that could inhibit HNF1beta (show HNF1B Antibodies)-mediated expression of uromodulin.
AGP was more effective in limiting hepatic inflammation and maintaining perfusion than saline or HAS, in both endotoxemic and septic mice. AGP sequestration of LPS (show TLR4 Antibodies) may contribute to its anti-inflammatory effects.
UMOD upregulates TRPV5 (show TRPV5 Antibodies) by decreasing caveolin-1 (show CAV1 Antibodies) dependent endocytosis of TRPV5 (show TRPV5 Antibodies).
UMOD regulates sodium uptake in the thick ascending limb of the loop of Henle by modulating the effect of tumor necrosis factor-alpha (show TNF Antibodies) on NKCC2A expression, making UMOD an important determinant of blood pressure control.
Genetic susceptibility link to hypertension and chronic kidney disease to uromodulin expression and uromodulin's effect on salt reabsorption in the kidney.
Using an ischemia-reperfusion model of murine acute kidney injury, we show that, while THP expression in thick ascending loop is downregulated at the peak of injury, it is significantly upregulated 48 h after.
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
, Tamm-Horsfall urinary glycoprotein
, tamm-Horsfall urinary glycoprotein
, uromodulin (uromucoid, Tamm-Horsfall glycoprotein)
, Urmodulin (Tamm-Horsfall protein)
, uromucoid, human : Tamm-Horsfall glycoprotein