anti-Uromodulin (UMOD) Antibodies

UMOD encodes uromodulin, the most abundant protein in normal urine. Additionally we are shipping Uromodulin Kits (64) and Uromodulin Proteins (21) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
UMOD 7369 P07911
UMOD 22242 Q91X17
UMOD 25128 P27590
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Top anti-Uromodulin Antibodies at antibodies-online.com

Showing 10 out of 183 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-UMOD Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>THP-1 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-UMOD Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>THP-1 cell lysate WB Suggested Anti-UMOD <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500 <br /> Positive Control: THP-1 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of Uromodulin expression in HEK293T (A), THP1 (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC (p), WB UMOD Antibody (Center) (ABIN658177) western blot analysis in MDA-MB453 cell line lysates (35 µg/lane). This demonstrates the UMOD antibody detected the UMOD protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse kidney tissue labeled with Anti-MCKD2/UMOD Polyclonal Antibody, Unconjugated (ABIN678473) at 1:200 followed by conjugation to the secondary antibody and DAB staining L1 rat kidney lysates, L2 human kidney carcinoma lysates probed (ABIN678473) Anti MCKD2/UMOD Polyclonal, Unconjugated at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band and observed band size: 65kD. 100 μL Log in to see 3 to 7 Days
$306.90
Details
Dog Mouse FITC EIA, IHC (fro), IF, IHC (p)   0.1 mg Log in to see 6 to 8 Days
$500.50
Details
Dog Mouse Un-conjugated EIA, IHC (fro), IF, IHC (p)   0.25 mg Log in to see 6 to 8 Days
$588.50
Details
Dog Mouse HRP EIA, IHC (fro), IF, IHC (p), RIA   0.1 mg Log in to see 6 to 8 Days
$588.50
Details
Human Mouse Un-conjugated IP, ELISA, WB Detection limit for recombinant GST tagged UMOD is 0.3 ng/ml as a capture antibody. Western Blot analysis of UMOD expression in transfected 293T cell line by UMOD monoclonal antibody (M03), clone 3F10.<br><br>Lane 1: UMOD transfected lysate (Predicted MW: 66.7 KDa).<br>Lane 2: Non-transfected lysate.<br> 100 μg Log in to see 11 to 12 Days
$440.00
Details
Cow Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details

UMOD Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Uromodulin Antibodies

  1. Human Polyclonal Uromodulin Primary Antibody for IHC (fro), ELISA - ABIN2476682 : Conner, Mansour: Serotonin receptor-mediated activation of adenylate cyclase in the neuroblastoma NCB.20: a novel 5-hydroxytryptamine receptor. in Molecular pharmacology 1990 (PubMed)
    Show all 4 Pubmed References

  2. Human Monoclonal Uromodulin Primary Antibody for IP, ELISA - ABIN521253 : Jou, Fang, Chen, Chen, Cheng, Shen, Liao, Tsai: Proteomic study of renal uric acid stone. in Urology 2012 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal Uromodulin Primary Antibody for IF, IHC (p) - ABIN521251 : Larkin, Zhang, Godfrey, Molostvov, Zehnder, Rabbani, Thornalley: Glucose-induced down regulation of thiamine transporters in the kidney proximal tubular epithelium produces thiamine insufficiency in diabetes. in PLoS ONE 2013 (PubMed)

  4. Human Polyclonal Uromodulin Primary Antibody for IF (p) - ABIN729800 : Cho, Song, Oh, Kim, Ko, Lee, Jo: Fate of Neutrophils during the Recovery Phase of Ischemia/Reperfusion Induced Acute Kidney Injury. in Journal of Korean medical science 2017 (PubMed)

More Antibodies against Uromodulin Interaction Partners

Human Uromodulin (UMOD) interaction partners

  1. we report a novel UMOD mutation in a Brazilian family with 11 affected members, and we discuss the importance of performing genetic testing in families with inherited kidney disease of unknown cause.

  2. Studied genetic association of uromodulin SNP in kidney function of patients with hypertension and cardiovascular disease.

  3. Single-nucleotide polymorphism in UMOD gene is associated with type 2 diabetes.

  4. UMOD gene variants in humans fulfill the criteria for ascribing a gene as causal of Hypertension.

  5. The missense mutation p.142R>R/Q in the uromodulin gene in patients with cast Nephropathy in Multiple Myeloma.

  6. Data show that one SNP (rs183962941), located in a non-coding region of uromodulin protein (UMOD), was nominally associated with end-stage renal disease (ESRD).

  7. THP appears to participate directly in complement inactivation by its ability to act as a cofactor for C3b degradation.

  8. High urinary uromodulin levels are associated with lower risk for UTI (show AMBP Antibodies) in older community-dwelling adults independent of traditional UTI (show AMBP Antibodies) risk factors.

  9. The uromodulin-CFH (show CFH Antibodies) interaction enhanced the cofactor activity of CFH (show CFH Antibodies) for factor I-mediated cleavage of C3b to inactivated C3b.

  10. These findings suggest that the levels of urinary microvesicle-bound uromodulin are associated with the severity of diabetic kidney disease.

Mouse (Murine) Uromodulin (UMOD) interaction partners

  1. results strongly suggest that the progressive worsening of kidney functions reflects the accumulation of the deleterious effects of the misfolded mutant THP and the compensatory responses

  2. Endoplasmic reticulum stress and apoptosis are key features in a mouse model of kidney disease driven by the uromodulin p.Cys147Trp mutation.

  3. Consistently, pathway enrichment analysis indicates that mutant uromodulin expression affects ER function and protein homeostasis.

  4. we show that Tamm-Horsfall protein deficiency stimulates proximal epithelial activation of the Interleukin-23/Interleukin-17 (show IL17A Antibodies) axis and systemic neutrophilia.

  5. TNFalpha (show TNF Antibodies) regulates uromodulin expression in a homeostatic setting, but the impact of TNFalpha (show TNF Antibodies) on uromodulin during kidney injury is superseded by other factors that could inhibit HNF1beta (show HNF1B Antibodies)-mediated expression of uromodulin.

  6. AGP was more effective in limiting hepatic inflammation and maintaining perfusion than saline or HAS, in both endotoxemic and septic mice. AGP sequestration of LPS (show TLR4 Antibodies) may contribute to its anti-inflammatory effects.

  7. UMOD upregulates TRPV5 (show TRPV5 Antibodies) by decreasing caveolin-1 (show CAV1 Antibodies) dependent endocytosis of TRPV5 (show TRPV5 Antibodies).

  8. UMOD regulates sodium uptake in the thick ascending limb of the loop of Henle by modulating the effect of tumor necrosis factor-alpha (show TNF Antibodies) on NKCC2A expression, making UMOD an important determinant of blood pressure control.

  9. Genetic susceptibility link to hypertension and chronic kidney disease to uromodulin expression and uromodulin's effect on salt reabsorption in the kidney.

  10. Using an ischemia-reperfusion model of murine acute kidney injury, we show that, while THP expression in thick ascending loop is downregulated at the peak of injury, it is significantly upregulated 48 h after.

Cow (Bovine) Uromodulin (UMOD) interaction partners

Uromodulin (UMOD) Antigen Profile

Protein Summary

This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.

Gene names and symbols associated with anti-Uromodulin (UMOD) Antibodies

  • uromodulin (UMOD) antibody
  • uromodulin (Umod) antibody
  • ADMCKD2 antibody
  • FJHN antibody
  • HNFJ antibody
  • HNFJ1 antibody
  • MCKD2 antibody
  • THGP antibody
  • THP antibody
  • urehr4 antibody

Protein level used designations for anti-Uromodulin (UMOD) Antibodies

uromodulin , Tamm-Horsfall urinary glycoprotein , uromucoid , THP , tamm-Horsfall urinary glycoprotein , uromodulin (uromucoid, Tamm-Horsfall glycoprotein) , Urmodulin (Tamm-Horsfall protein) , uromucoid, human : Tamm-Horsfall glycoprotein

GENE ID SPECIES
695883 Macaca mulatta
100026222 Monodelphis domestica
7369 Homo sapiens
403510 Canis lupus familiaris
22242 Mus musculus
25128 Rattus norvegicus
281567 Bos taurus
100730507 Cavia porcellus
100173805 Pongo abelii
100511125 Sus scrofa
100342440 Oryctolagus cuniculus
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