Uroplakin 2 Proteins (UPK2)

Human Uroplakin 2 (UPK2) interaction partners

1. Uroplakin II was immunopositive in 53% and 60% of urothelial carcinomas (UC) of the bladder and the ureter, respectively.

2. These results suggest that whereas GATA-3 and uroplakin II may be most useful in the diagnosis of urothelial carcinoma metastasis, p40 may be additionally suited as a prognostic marker.

3. UPII, GATA3, and p40, when used in combination, are highly sensitive in the differential diagnosis of invasive urothelial carcinoma.

4. UPII was highly specific/moderately sensitive for urothelial carcinoma. May be a potentially useful marker to identify urothelial lineage and help distinguish UC from prostate cancer or, in conjunction with GATA3 (show GATA3 Proteins), from metastatic breast cancer.

5. UPII demonstrates a significantly higher sensitivity than UPIII (show UPK3A Proteins) in conventional and variant urothelial carcinomas

6. Uroplakin II antibody BC21 demonstrated superior sensitivity and specificity in urothelial carcinoma, compared with uroplakin III (show UPK3A Proteins), suggesting an advantage in differential diagnosis of urothelial carcinoma and in the detection of tumors of unknown origin.

7. combination of prostate stem cell antigen (show PSCA Proteins) enhancer and uroplakin II promoter is feasible in constructing bladder cancer-specific vectors

8. study offers no definitive support for uroplakin II mutations causing human renal tract malformations

Mouse (Murine) Uroplakin 2 (UPK2) interaction partners

1. Conversely, repair of focal mucosal defects not only employs this mechanism, but in parallel host intermediate cell daughters expressing uroplakin 2 give rise to themselves and are also contributors to superficial cells in neotissues.

2. The despites a lower level of expression, UPII maintain its plaque association in urothelial preneoplastic lesions.

3. Bladder-specific autoimmune response sufficient to induce inflammation and interstitial cystitis occurs in mice following immunization with recombinant murine UPK2.

4. The UPII knockout abolished plaque formation, indicating that both uroplakin heterodimers (UPIa (show UPK1A Proteins)/II and UPIb (show UPK1B Proteins)/III or IIIb) are required for plaque assembly.

Pig (Porcine) Uroplakin 2 (UPK2) interaction partners

1. HNF4 (show HNF4A Proteins) positively regulates pUPII gene promoter activity.