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UPK3B is a minor component of the apical plaques of mammalian urothelium that binds and dimerizes with uroplakin-1b (UPK1B\; MIM 602380), one of the major conserved urothelium membrane proteins. Additionally we are shipping Uroplakin 3B Proteins (4) and and many more products for this protein.
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These results indicate that p35 (uroplakin IIIb) is a urothelial differentiation product structurally and functionally related to uroplakin III, and that p35-UPIb interaction in the ER is an important early step in urothelial plaque assembly.
The data suggest that UPK3B may play a pivotal role in the maturation of gametes and gamete-delivery organs.
LRRN4 was only detected in primary mesothelial cells, but MSLN and UPK3B were also detected in other cell types.
UPK3B is a minor component of the apical plaques of mammalian urothelium that binds and dimerizes with uroplakin-1b (UPK1B; MIM 602380), one of the major conserved urothelium membrane proteins. The other major conserved integral membrane proteins of urothelial plaques are UPK1A (MIM 611557), UPK2 (MIM 611558), and UPK3A (MIM 611559) (Deng et al., 2002
, uroplakin IIIB
, uroplakin IIIb
, uroplakin 3B
, Uroplakin IIIb