Uroporphyrinogen III Synthase Proteins (UROS)

The protein encoded by UROS catalyzes the fourth step of porphyrin biosynthesis in the heme biosynthetic pathway. Additionally we are shipping Uroporphyrinogen III Synthase Antibodies (20) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UROS 7390 P10746
UROS 22276 P51163
Rat UROS UROS 309070  
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Top Uroporphyrinogen III Synthase Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Human His tag   50 μg 4 Days
$522.50
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Escherichia coli (E. coli) Human His tag Validation with Western Blot 10 μg 4 to 8 Days
$394.90
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
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Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
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Escherichia coli (E. coli) Human His tag 100 μg 15 to 19 Days
$400.00
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Yeast Arabidopsis thaliana His tag   1 mg 60 to 71 Days
$2,610.67
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Yeast Rice His tag   1 mg 60 to 71 Days
$2,647.33
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Escherichia coli (E. coli) Human His tag   10 μg 15 to 16 Days
$300.00
Details

UROS Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

More Proteins for Uroporphyrinogen III Synthase (UROS) Interaction Partners

Cow (Bovine) Uroporphyrinogen III Synthase (UROS) interaction partners

  1. Study substantiated that insufficient activity of UROS is the cause of CEP in the family studied here. and provided strong evidence for LD between markers within the region and the phenotype.

Human Uroporphyrinogen III Synthase (UROS) interaction partners

  1. we show evidence that abnormal protein homeostasis is a prevalent mechanism responsible for UROS deficiency and that modulators of UROS proteolysis such as proteasome inhibitors or chemical chaperones may represent an attractive therapeutic option to reduce porphyrin accumulation and prevent skin photosensitivity in Congenital erythropoietic porphyria (CEP)patients when the genotype includes a missense variant.

  2. A, T to C change at nucleotide 34313, leading to a substitution of Leucine by Proline at codon 237, was observed in the homozygous state in a family with congenital erythropoietic porphyria.

  3. REVIEW: Structural, thermodynamic, and mechanistical studies in uroporphyrinogen III synthase and molecular basis of congenital erythropoietic porphyria

  4. Intracellular rescue of the uroporphyrinogen III synthase activity in enzymes carrying the hotspot mutation C73R.

  5. Data show that branchpoint sequence (BPS)mutation reduced the wild-type transcript and UROS enzyme activity in CEP lymphoblasts to approximately 10% and 15% of normal, respectively.

  6. two novel misense mutations in the UROS gene.

  7. NMR analyses of URO-synthase titrated with competitive inhibitors N(D)-methyl-1-formylbilane or URO'gen III, revealed resonance perturbations of specific residues lining the cleft between 2 major domains of URO synthase that mapped enzyme's active site.

  8. The decrease in the expression of ubiquitous HMBS and UROS mRNAs under hypoxia is associated with accumulation of hypoxia-inducible factor 1alpha protein.

  9. UROS mutations related to erythropoietic porphyria identify a key helix for protein stability.

Mouse (Murine) Uroporphyrinogen III Synthase (UROS) interaction partners

  1. Data show that in adult UROS C73R mice, spleen and liver weights were 8.2- and 1.5-fold increased, respectively.

Arabidopsis thaliana Uroporphyrinogen III Synthase (UROS) interaction partners

  1. Data show that AtDuf3 genes were expressed in roots, leaves, shoot apical meristems, anthers and pollen grains. They may form homodimers or homopolymers, but did not interact with other members of the same family.

  2. Identification of this gene in this plant by using functional complementation.

Uroporphyrinogen III Synthase (UROS) Protein Profile

Protein Summary

The protein encoded by this gene catalyzes the fourth step of porphyrin biosynthesis in the heme biosynthetic pathway. Defects in this gene cause congenital erythropoietic porphyria (Gunther's disease).

Gene names and symbols associated with UROS

  • uroporphyrinogen III synthase (uros)
  • uroporphyrinogen III synthase (UROS)
  • uroporphyrinogen-III synthase (UroS) (AFUA_6G12800)
  • uroporphyrinogen-iii synthase (UROS)
  • uroporphyrinogen III synthase (UroS)
  • uroporphyrinogen III synthase L homeolog (uros.L)
  • uroporphyrinogen III synthase (Uros)
  • uroporphyrinogen-III synthase family protein (HEMD)
  • Afu6g12800 protein
  • AI415298 protein
  • ARABIDOPSIS THALIANA UROPORPHYRINOGEN III SYNTHASE protein
  • ATDUF3 protein
  • ATUROS protein
  • DOMAIN OF UNKNOWN FUNCTION 724 3 protein
  • DUF3 protein
  • MGC85561 protein
  • T9J22.21 protein
  • T9J22_21 protein
  • UROIIIS protein
  • UROPORPHYRINOGEN III SYNTHASE protein
  • UROS protein
  • Uros3 protein
  • wu:fd13d11 protein
  • zgc:110240 protein

Protein level used designations for UROS

uroporphyrinogen-III synthase , uroporphyrinogen III synthase (congenital erythropoietic porphyria) , hydroxymethylbilane hydrolyase, cyclizing , uroporphyrinogen-III cosynthetase , uroporphyrinogen-iii synthase , uroporphyrinogen III synthase , hydroxymethylbilane hydrolyase , uroporphyrinogen-III cosynthase , URO-synthase , UROIIIS , hydroxymethylbilane hydrolyase (cyclizing) , urogen III synthase , uroporphyrinogen III co-synthase

GENE ID SPECIES
404731 Danio rerio
426223 Gallus gallus
450813 Pan troglodytes
492116 Canis lupus familiaris
613425 Bos taurus
696043 Macaca mulatta
3508465 Aspergillus fumigatus Af293
5722253 Chlamydomonas reinhardtii
7452914 Thalassiosira pseudonana CCMP1335
100037610 Triticum aestivum
447178 Xenopus laevis
7390 Homo sapiens
22276 Mus musculus
309070 Rattus norvegicus
817195 Arabidopsis thaliana
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